Correlation between myocardial enzyme serum levels and markers of inflammation with severity of coronary artery disease and Gensini score: A hospital-based, prospective study in Greek patients

Vasileios Peppes, George Rammos, Efstathios Manios, Eleni Koroboki, Stylianos Rokas, Nikolaos ZakopoulosDepartment of Clinical Therapeutics, Alexandra Hospital, University of Athens School of Medicine, Athens, GreeceBackground: Our objective was to associate serum levels of myocardial enzymes and in...

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Autores principales:	Vasileios Peppes, George Rammos, Efstathios Manios, Eleni Koroboki, Stylianos Rokas, Nikolaos Zakopoulos
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2008
Materias:	Myocardial enzymes inflammation coronary angiography Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/44d3072462c64a8c93b4793a6bb7b0c7
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spelling	oai:doaj.org-article:44d3072462c64a8c93b4793a6bb7b0c72021-12-02T04:50:56ZCorrelation between myocardial enzyme serum levels and markers of inflammation with severity of coronary artery disease and Gensini score: A hospital-based, prospective study in Greek patients1178-1998https://doaj.org/article/44d3072462c64a8c93b4793a6bb7b0c72008-12-01T00:00:00Zhttps://www.dovepress.com/correlation-between-myocardial-enzyme-serum-levels-and-markers-of-infl-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Vasileios Peppes, George Rammos, Efstathios Manios, Eleni Koroboki, Stylianos Rokas, Nikolaos ZakopoulosDepartment of Clinical Therapeutics, Alexandra Hospital, University of Athens School of Medicine, Athens, GreeceBackground: Our objective was to associate serum levels of myocardial enzymes and inflammatory biomarkers with severity of coronary artery disease (CAD).Patients and methods: 123 patients participated in our study, including 65 cases of acute myocardial infarction (MI), 27 cases of newly diagnosed CAD – without MI – and 31 controls. In all subjects, myocardial serum enzyme levels (creatine phosphokinase, aspartate aminotransferase, lactate dehydrogenase) and inflammatory indices (C-reactive protein, fibrinogen, white blood cells, and erythrocyte sedimentation rate) were measured. Patients were all submitted to coronary angiography and CAD severity was evaluated by Gensini score.Results: Significant differences concerning enzyme serum levels and inflammatory indices were found to exist between the three study groups, being highest among patients with acute MI (p < 0.001). A significant  association was demonstrated between Gensini score and serum enzyme levels as well as inflammatory biomarkers.Conclusions: Our findings suggest that serum levels of myocardial enzymes and inflammatory indices correlate with CAD severity in Greek patients.Keywords: myocardial enzymes, inflammation, coronary angiography, coronary artery diseaseVasileios PeppesGeorge RammosEfstathios ManiosEleni KorobokiStylianos RokasNikolaos ZakopoulosDove Medical PressarticleMyocardial enzymesinflammationcoronary angiographyGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 3, Pp 699-710 (2008)
institution	DOAJ
collection	DOAJ
language	EN
topic	Myocardial enzymes inflammation coronary angiography Geriatrics RC952-954.6
spellingShingle	Myocardial enzymes inflammation coronary angiography Geriatrics RC952-954.6 Vasileios Peppes George Rammos Efstathios Manios Eleni Koroboki Stylianos Rokas Nikolaos Zakopoulos Correlation between myocardial enzyme serum levels and markers of inflammation with severity of coronary artery disease and Gensini score: A hospital-based, prospective study in Greek patients
description	Vasileios Peppes, George Rammos, Efstathios Manios, Eleni Koroboki, Stylianos Rokas, Nikolaos ZakopoulosDepartment of Clinical Therapeutics, Alexandra Hospital, University of Athens School of Medicine, Athens, GreeceBackground: Our objective was to associate serum levels of myocardial enzymes and inflammatory biomarkers with severity of coronary artery disease (CAD).Patients and methods: 123 patients participated in our study, including 65 cases of acute myocardial infarction (MI), 27 cases of newly diagnosed CAD – without MI – and 31 controls. In all subjects, myocardial serum enzyme levels (creatine phosphokinase, aspartate aminotransferase, lactate dehydrogenase) and inflammatory indices (C-reactive protein, fibrinogen, white blood cells, and erythrocyte sedimentation rate) were measured. Patients were all submitted to coronary angiography and CAD severity was evaluated by Gensini score.Results: Significant differences concerning enzyme serum levels and inflammatory indices were found to exist between the three study groups, being highest among patients with acute MI (p < 0.001). A significant  association was demonstrated between Gensini score and serum enzyme levels as well as inflammatory biomarkers.Conclusions: Our findings suggest that serum levels of myocardial enzymes and inflammatory indices correlate with CAD severity in Greek patients.Keywords: myocardial enzymes, inflammation, coronary angiography, coronary artery disease
format	article
author	Vasileios Peppes George Rammos Efstathios Manios Eleni Koroboki Stylianos Rokas Nikolaos Zakopoulos
author_facet	Vasileios Peppes George Rammos Efstathios Manios Eleni Koroboki Stylianos Rokas Nikolaos Zakopoulos
author_sort	Vasileios Peppes
title	Correlation between myocardial enzyme serum levels and markers of inflammation with severity of coronary artery disease and Gensini score: A hospital-based, prospective study in Greek patients
title_short	Correlation between myocardial enzyme serum levels and markers of inflammation with severity of coronary artery disease and Gensini score: A hospital-based, prospective study in Greek patients
title_full	Correlation between myocardial enzyme serum levels and markers of inflammation with severity of coronary artery disease and Gensini score: A hospital-based, prospective study in Greek patients
title_fullStr	Correlation between myocardial enzyme serum levels and markers of inflammation with severity of coronary artery disease and Gensini score: A hospital-based, prospective study in Greek patients
title_full_unstemmed	Correlation between myocardial enzyme serum levels and markers of inflammation with severity of coronary artery disease and Gensini score: A hospital-based, prospective study in Greek patients
title_sort	correlation between myocardial enzyme serum levels and markers of inflammation with severity of coronary artery disease and gensini score: a hospital-based, prospective study in greek patients
publisher	Dove Medical Press
publishDate	2008
url	https://doaj.org/article/44d3072462c64a8c93b4793a6bb7b0c7
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Correlation between myocardial enzyme serum levels and markers of inflammation with severity of coronary artery disease and Gensini score: A hospital-based, prospective study in Greek patients

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