Mechanistic clues to the protective effect of chrysin against doxorubicin-induced cardiomyopathy: Plausible roles of p53, MAPK and AKT pathways

Abstract Doxorubicin (DOX) is the mainstay chemotherapeutic agent against a variety of human neoplasmas. However, its clinical utility is limited by its marked cardiotoxicity. Chrysin, is a natural flavone which possesses antioxidant, anti-inflammatory and anti-cancer properties. The current study a...

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Bibliographic Details
Main Authors: Eman M. Mantawy, Ahmed Esmat, Wesam M. El-Bakly, Rania A. Salah ElDin, Ebtehal El-Demerdash
Format: article
Language:EN
Published: Nature Portfolio 2017
Subjects:
R
Q
Online Access:https://doaj.org/article/44d38144654e417ca70bc14dd22b09c3
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