Effects of body mass index-related disorders on cognition: preliminary results

Jerome A Yesavage,1,2 Lisa M Kinoshita,1,2 Art Noda,2 Laura C Lazzeroni,2 Jennifer Kaci Fairchild,1,2 Joy Taylor,1,2 Doina Kulick,3 Leah Friedman,1,2 Jauhtai Cheng,1,2 Jamie M Zeitzer,1,2 Ruth O’Hara1,21Department of Veterans Affairs Health Care System, Palo Alto, CA, USA; 2Department of...

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Autores principales:	Yesavage JA, Kinoshita LM, Noda A, Lazzeroni LC, Fairchild JK, Taylor J, Kulick D, Friedman L, Cheng J, Zeitzer JM, O'Hara R
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2014
Materias:	Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/44d66735d25947839809c6dd61f6403e
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spelling	oai:doaj.org-article:44d66735d25947839809c6dd61f6403e2021-12-02T08:57:35ZEffects of body mass index-related disorders on cognition: preliminary results1178-7007https://doaj.org/article/44d66735d25947839809c6dd61f6403e2014-05-01T00:00:00Zhttp://www.dovepress.com/effects-of-body-mass-index-related-disorders-on-cognition-preliminary--a16736https://doaj.org/toc/1178-7007 Jerome A Yesavage,1,2 Lisa M Kinoshita,1,2 Art Noda,2 Laura C Lazzeroni,2 Jennifer Kaci Fairchild,1,2 Joy Taylor,1,2 Doina Kulick,3 Leah Friedman,1,2 Jauhtai Cheng,1,2 Jamie M Zeitzer,1,2 Ruth O’Hara1,21Department of Veterans Affairs Health Care System, Palo Alto, CA, USA; 2Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA, USA; 3Department of Medicine, University of Nevada School of Medicine, Reno, NV, USABackground: Well-known risk factors for cognitive impairment are also associated with obesity. Research has highlighted genetic risk factors for obesity, yet the relationship of those risk factors with cognitive impairment is unknown. The objective of this study was to determine the associations between cognition, hypertension, diabetes, sleep-disordered breathing, and obesity. Genetic risk factors of obesity were also examined.Methods: The sample consisted of 369 nondemented individuals aged 50 years or older from four community cohorts. Primary outcome measures included auditory verbal memory, as measured by the Rey Auditory Verbal Learning Test, and executive functioning, as measured by the Color–Word Interference Test of the Delis–Kaplan Executive Function System battery. Apnea–hypopnea index indicators were determined during standard overnight polysomnography. Statistical analyses included Pearson correlations and linear regressions.Results: Poor executive function and auditory verbal memory were linked to cardiovascular risk factors, but not directly to obesity. Genetic factors appeared to have a small but measureable association to obesity.Conclusion: A direct linkage between obesity and poor executive function and auditory verbal memory is difficult to discern, possibly because nonobese individuals may show cognitive impairment due to insulin resistance and the “metabolic syndrome”.Keywords: sleep-disordered breathing, hypertension, diabetes, sleep apnea, BMI, obesityYesavage JAKinoshita LMNoda ALazzeroni LCFairchild JKTaylor JKulick DFriedman LCheng JZeitzer JMO'Hara RDove Medical PressarticleSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol 2014, Iss default, Pp 145-151 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Specialties of internal medicine RC581-951
spellingShingle	Specialties of internal medicine RC581-951 Yesavage JA Kinoshita LM Noda A Lazzeroni LC Fairchild JK Taylor J Kulick D Friedman L Cheng J Zeitzer JM O'Hara R Effects of body mass index-related disorders on cognition: preliminary results
description	Jerome A Yesavage,1,2 Lisa M Kinoshita,1,2 Art Noda,2 Laura C Lazzeroni,2 Jennifer Kaci Fairchild,1,2 Joy Taylor,1,2 Doina Kulick,3 Leah Friedman,1,2 Jauhtai Cheng,1,2 Jamie M Zeitzer,1,2 Ruth O’Hara1,21Department of Veterans Affairs Health Care System, Palo Alto, CA, USA; 2Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA, USA; 3Department of Medicine, University of Nevada School of Medicine, Reno, NV, USABackground: Well-known risk factors for cognitive impairment are also associated with obesity. Research has highlighted genetic risk factors for obesity, yet the relationship of those risk factors with cognitive impairment is unknown. The objective of this study was to determine the associations between cognition, hypertension, diabetes, sleep-disordered breathing, and obesity. Genetic risk factors of obesity were also examined.Methods: The sample consisted of 369 nondemented individuals aged 50 years or older from four community cohorts. Primary outcome measures included auditory verbal memory, as measured by the Rey Auditory Verbal Learning Test, and executive functioning, as measured by the Color–Word Interference Test of the Delis–Kaplan Executive Function System battery. Apnea–hypopnea index indicators were determined during standard overnight polysomnography. Statistical analyses included Pearson correlations and linear regressions.Results: Poor executive function and auditory verbal memory were linked to cardiovascular risk factors, but not directly to obesity. Genetic factors appeared to have a small but measureable association to obesity.Conclusion: A direct linkage between obesity and poor executive function and auditory verbal memory is difficult to discern, possibly because nonobese individuals may show cognitive impairment due to insulin resistance and the “metabolic syndrome”.Keywords: sleep-disordered breathing, hypertension, diabetes, sleep apnea, BMI, obesity
format	article
author	Yesavage JA Kinoshita LM Noda A Lazzeroni LC Fairchild JK Taylor J Kulick D Friedman L Cheng J Zeitzer JM O'Hara R
author_facet	Yesavage JA Kinoshita LM Noda A Lazzeroni LC Fairchild JK Taylor J Kulick D Friedman L Cheng J Zeitzer JM O'Hara R
author_sort	Yesavage JA
title	Effects of body mass index-related disorders on cognition: preliminary results
title_short	Effects of body mass index-related disorders on cognition: preliminary results
title_full	Effects of body mass index-related disorders on cognition: preliminary results
title_fullStr	Effects of body mass index-related disorders on cognition: preliminary results
title_full_unstemmed	Effects of body mass index-related disorders on cognition: preliminary results
title_sort	effects of body mass index-related disorders on cognition: preliminary results
publisher	Dove Medical Press
publishDate	2014
url	https://doaj.org/article/44d66735d25947839809c6dd61f6403e
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Effects of body mass index-related disorders on cognition: preliminary results

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