Parents with periodontitis impact the subgingival colonization of their offspring

Abstract Early acquisition of a pathogenic microbiota and the presence of dysbiosis in childhood is associated with susceptibility to and the familial aggregation of periodontitis. This longitudinal interventional case–control study aimed to evaluate the impact of parental periodontal disease on the...

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Autores principales:	Mabelle Freitas Monteiro, Khaled Altabtbaei, Purnima S. Kumar, Márcio Zaffalon Casati, Karina Gonzales Silverio Ruiz, Enilson Antonio Sallum, Francisco Humberto Nociti-Junior, Renato Corrêa Viana Casarin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/44dbd142698d4ea68cef0e814756fbad
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spelling	oai:doaj.org-article:44dbd142698d4ea68cef0e814756fbad2021-12-02T15:23:04ZParents with periodontitis impact the subgingival colonization of their offspring10.1038/s41598-020-80372-42045-2322https://doaj.org/article/44dbd142698d4ea68cef0e814756fbad2021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-80372-4https://doaj.org/toc/2045-2322Abstract Early acquisition of a pathogenic microbiota and the presence of dysbiosis in childhood is associated with susceptibility to and the familial aggregation of periodontitis. This longitudinal interventional case–control study aimed to evaluate the impact of parental periodontal disease on the acquisition of oral pathogens in their offspring. Subgingival plaque and clinical periodontal metrics were collected from 18 parents with a history of generalized aggressive periodontitis and their children (6–12 years of age), and 18 periodontally healthy parents and their parents at baseline and following professional oral prophylaxis. 16S rRNA amplicon sequencing revealed that parents were the primary source of the child's microbiome, affecting their microbial acquisition and diversity. Children of periodontitis parents were preferentially colonized by Filifactor alocis, Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans, Streptococcus parasanguinis, Fusobacterium nucleatum and several species belonging to the genus Selenomonas even in the absence of periodontitis, and these species controlled inter-bacterial interactions. These pathogens also emerged as robust discriminators of the microbial signatures of children of parents with periodontitis. Plaque control did not modulate this pathogenic pattern, attesting to the microbiome's resistance to change once it has been established. This study highlights the critical role played by parental disease in microbial colonization patterns in their offspring and the early acquisition of periodontitis-related species and underscores the need for greater surveillance and preventive measures in families of periodontitis patients.Mabelle Freitas MonteiroKhaled AltabtbaeiPurnima S. KumarMárcio Zaffalon CasatiKarina Gonzales Silverio RuizEnilson Antonio SallumFrancisco Humberto Nociti-JuniorRenato Corrêa Viana CasarinNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Mabelle Freitas Monteiro Khaled Altabtbaei Purnima S. Kumar Márcio Zaffalon Casati Karina Gonzales Silverio Ruiz Enilson Antonio Sallum Francisco Humberto Nociti-Junior Renato Corrêa Viana Casarin Parents with periodontitis impact the subgingival colonization of their offspring
description	Abstract Early acquisition of a pathogenic microbiota and the presence of dysbiosis in childhood is associated with susceptibility to and the familial aggregation of periodontitis. This longitudinal interventional case–control study aimed to evaluate the impact of parental periodontal disease on the acquisition of oral pathogens in their offspring. Subgingival plaque and clinical periodontal metrics were collected from 18 parents with a history of generalized aggressive periodontitis and their children (6–12 years of age), and 18 periodontally healthy parents and their parents at baseline and following professional oral prophylaxis. 16S rRNA amplicon sequencing revealed that parents were the primary source of the child's microbiome, affecting their microbial acquisition and diversity. Children of periodontitis parents were preferentially colonized by Filifactor alocis, Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans, Streptococcus parasanguinis, Fusobacterium nucleatum and several species belonging to the genus Selenomonas even in the absence of periodontitis, and these species controlled inter-bacterial interactions. These pathogens also emerged as robust discriminators of the microbial signatures of children of parents with periodontitis. Plaque control did not modulate this pathogenic pattern, attesting to the microbiome's resistance to change once it has been established. This study highlights the critical role played by parental disease in microbial colonization patterns in their offspring and the early acquisition of periodontitis-related species and underscores the need for greater surveillance and preventive measures in families of periodontitis patients.
format	article
author	Mabelle Freitas Monteiro Khaled Altabtbaei Purnima S. Kumar Márcio Zaffalon Casati Karina Gonzales Silverio Ruiz Enilson Antonio Sallum Francisco Humberto Nociti-Junior Renato Corrêa Viana Casarin
author_facet	Mabelle Freitas Monteiro Khaled Altabtbaei Purnima S. Kumar Márcio Zaffalon Casati Karina Gonzales Silverio Ruiz Enilson Antonio Sallum Francisco Humberto Nociti-Junior Renato Corrêa Viana Casarin
author_sort	Mabelle Freitas Monteiro
title	Parents with periodontitis impact the subgingival colonization of their offspring
title_short	Parents with periodontitis impact the subgingival colonization of their offspring
title_full	Parents with periodontitis impact the subgingival colonization of their offspring
title_fullStr	Parents with periodontitis impact the subgingival colonization of their offspring
title_full_unstemmed	Parents with periodontitis impact the subgingival colonization of their offspring
title_sort	parents with periodontitis impact the subgingival colonization of their offspring
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/44dbd142698d4ea68cef0e814756fbad
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Parents with periodontitis impact the subgingival colonization of their offspring

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