Screening Leads to Overestimated Associations of Thyroid Dysfunction and Thyroiditis with Thyroid Cancer Risk

We aimed to assess the relationships of functional thyroid disease and thyroiditis with subsequent thyroid cancer, which is controversial due to various confounders, and the effect of thyroid disease workup on this association. We used the cohort data from 2002 to 2015 (Study I, <i>n</i>...

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Autores principales:	Young Shin Song, Kyung Soo Kim, Soo Kyung Kim, Young Wook Cho, Hyo Geun Choi
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	thyroid cancer hyperthyroidism hypothyroidism screening nationwide studies case-control studies Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/44e077f5f842469e86435c0f8b3b3c6a
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spelling	oai:doaj.org-article:44e077f5f842469e86435c0f8b3b3c6a2021-11-11T15:29:47ZScreening Leads to Overestimated Associations of Thyroid Dysfunction and Thyroiditis with Thyroid Cancer Risk10.3390/cancers132153852072-6694https://doaj.org/article/44e077f5f842469e86435c0f8b3b3c6a2021-10-01T00:00:00Zhttps://www.mdpi.com/2072-6694/13/21/5385https://doaj.org/toc/2072-6694We aimed to assess the relationships of functional thyroid disease and thyroiditis with subsequent thyroid cancer, which is controversial due to various confounders, and the effect of thyroid disease workup on this association. We used the cohort data from 2002 to 2015 (Study I, <i>n</i> = 28,330) and the entire data from 2002 to 2019 (Study II, <i>n</i> = 883,074) of the Korean National Health Insurance Service database, and performed logistic regression and subgroup analyses with various covariates. In Study I, hypothyroidism, thyroiditis, autoimmune thyroiditis, hyperthyroidism, and Graves’ disease showed positive associations with thyroid cancer. In Study II, after adjustment for covariates including the number of thyroid function tests, the ORs for thyroid cancer were significantly reduced in all thyroid diseases. Hypothyroidism, thyroiditis, and autoimmune thyroiditis were positively associated (adjusted odds ratio, OR (95% confidence interval, CI) 1.28 (1.25–1.32), 1.36 (1.31–1.42), and 1.17 (1.11–1.24), respectively), whereas hyperthyroidism and Graves’ disease were negatively associated with thyroid cancer (adjusted OR (95% CI) 0.80 (0.77–0.83) and 0.69 (0.65–0.74), respectively). Multiple subgroup analyses in both studies showed consistent results. In this large population-based, nationwide study, we confirmed that thyroid disease workup leads to overestimation of associations of thyroid dysfunction and thyroiditis with thyroid cancer risk.Young Shin SongKyung Soo KimSoo Kyung KimYoung Wook ChoHyo Geun ChoiMDPI AGarticlethyroid cancerhyperthyroidismhypothyroidismscreeningnationwide studiescase-control studiesNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENCancers, Vol 13, Iss 5385, p 5385 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	thyroid cancer hyperthyroidism hypothyroidism screening nationwide studies case-control studies Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	thyroid cancer hyperthyroidism hypothyroidism screening nationwide studies case-control studies Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Young Shin Song Kyung Soo Kim Soo Kyung Kim Young Wook Cho Hyo Geun Choi Screening Leads to Overestimated Associations of Thyroid Dysfunction and Thyroiditis with Thyroid Cancer Risk
description	We aimed to assess the relationships of functional thyroid disease and thyroiditis with subsequent thyroid cancer, which is controversial due to various confounders, and the effect of thyroid disease workup on this association. We used the cohort data from 2002 to 2015 (Study I, <i>n</i> = 28,330) and the entire data from 2002 to 2019 (Study II, <i>n</i> = 883,074) of the Korean National Health Insurance Service database, and performed logistic regression and subgroup analyses with various covariates. In Study I, hypothyroidism, thyroiditis, autoimmune thyroiditis, hyperthyroidism, and Graves’ disease showed positive associations with thyroid cancer. In Study II, after adjustment for covariates including the number of thyroid function tests, the ORs for thyroid cancer were significantly reduced in all thyroid diseases. Hypothyroidism, thyroiditis, and autoimmune thyroiditis were positively associated (adjusted odds ratio, OR (95% confidence interval, CI) 1.28 (1.25–1.32), 1.36 (1.31–1.42), and 1.17 (1.11–1.24), respectively), whereas hyperthyroidism and Graves’ disease were negatively associated with thyroid cancer (adjusted OR (95% CI) 0.80 (0.77–0.83) and 0.69 (0.65–0.74), respectively). Multiple subgroup analyses in both studies showed consistent results. In this large population-based, nationwide study, we confirmed that thyroid disease workup leads to overestimation of associations of thyroid dysfunction and thyroiditis with thyroid cancer risk.
format	article
author	Young Shin Song Kyung Soo Kim Soo Kyung Kim Young Wook Cho Hyo Geun Choi
author_facet	Young Shin Song Kyung Soo Kim Soo Kyung Kim Young Wook Cho Hyo Geun Choi
author_sort	Young Shin Song
title	Screening Leads to Overestimated Associations of Thyroid Dysfunction and Thyroiditis with Thyroid Cancer Risk
title_short	Screening Leads to Overestimated Associations of Thyroid Dysfunction and Thyroiditis with Thyroid Cancer Risk
title_full	Screening Leads to Overestimated Associations of Thyroid Dysfunction and Thyroiditis with Thyroid Cancer Risk
title_fullStr	Screening Leads to Overestimated Associations of Thyroid Dysfunction and Thyroiditis with Thyroid Cancer Risk
title_full_unstemmed	Screening Leads to Overestimated Associations of Thyroid Dysfunction and Thyroiditis with Thyroid Cancer Risk
title_sort	screening leads to overestimated associations of thyroid dysfunction and thyroiditis with thyroid cancer risk
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/44e077f5f842469e86435c0f8b3b3c6a
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Screening Leads to Overestimated Associations of Thyroid Dysfunction and Thyroiditis with Thyroid Cancer Risk

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