IMMUNOSUPPRESSIVE EFFECTS OF ARGININE DEIMINASE FROM STREPTOCOCCUS PYOGENES

Many pathogens use metabolic pathway of arginine for successful dissemination. Bacterial arginine deiminase hydrolyzes arginine to form one molecule of ammonia and two molecules of ATP. The activity of the enzyme contributes to the improvement of survival of pathogenic bacteria in conditions of low...

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Autores principales:	E. A. Starikova, A. V. Sokolov, L. A. Burova, I. S. Freidlin
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2015
Materias:	arginine deiminase streptococcus pyogenes immunosuppression Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/44e07b72652e4e4a824a251de0ea5a3c
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spelling	oai:doaj.org-article:44e07b72652e4e4a824a251de0ea5a3c2021-11-18T08:03:45ZIMMUNOSUPPRESSIVE EFFECTS OF ARGININE DEIMINASE FROM STREPTOCOCCUS PYOGENES1563-06252313-741X10.15789/1563-0625-2015-4-303-318https://doaj.org/article/44e07b72652e4e4a824a251de0ea5a3c2015-10-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/922https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XMany pathogens use metabolic pathway of arginine for successful dissemination. Bacterial arginine deiminase hydrolyzes arginine to form one molecule of ammonia and two molecules of ATP. The activity of the enzyme contributes to the improvement of survival of pathogenic bacteria in conditions of low pH at the site of infection or in phagolysosome, as well as in anaerobic conditions, and also leads to deficiency of arginine. Metabolism of arginine plays an important role in regulating the functions of immune system cells in mammals. Arginine is a substrate of enzymes NOS and arginase. Arginine depletion, potentially contributs to immunosuppression. The review analyzed the literature data on the effect of streptococcal arginine deiminase on the metabolism of arginine eukaryotic cells, and discusses immunosuppressive action of the enzyme.E. A. StarikovaA. V. SokolovL. A. BurovaI. S. FreidlinSPb RAACIarticlearginine deiminasestreptococcus pyogenesimmunosuppressionImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 17, Iss 4, Pp 303-318 (2015)
institution	DOAJ
collection	DOAJ
language	RU
topic	arginine deiminase streptococcus pyogenes immunosuppression Immunologic diseases. Allergy RC581-607
spellingShingle	arginine deiminase streptococcus pyogenes immunosuppression Immunologic diseases. Allergy RC581-607 E. A. Starikova A. V. Sokolov L. A. Burova I. S. Freidlin IMMUNOSUPPRESSIVE EFFECTS OF ARGININE DEIMINASE FROM STREPTOCOCCUS PYOGENES
description	Many pathogens use metabolic pathway of arginine for successful dissemination. Bacterial arginine deiminase hydrolyzes arginine to form one molecule of ammonia and two molecules of ATP. The activity of the enzyme contributes to the improvement of survival of pathogenic bacteria in conditions of low pH at the site of infection or in phagolysosome, as well as in anaerobic conditions, and also leads to deficiency of arginine. Metabolism of arginine plays an important role in regulating the functions of immune system cells in mammals. Arginine is a substrate of enzymes NOS and arginase. Arginine depletion, potentially contributs to immunosuppression. The review analyzed the literature data on the effect of streptococcal arginine deiminase on the metabolism of arginine eukaryotic cells, and discusses immunosuppressive action of the enzyme.
format	article
author	E. A. Starikova A. V. Sokolov L. A. Burova I. S. Freidlin
author_facet	E. A. Starikova A. V. Sokolov L. A. Burova I. S. Freidlin
author_sort	E. A. Starikova
title	IMMUNOSUPPRESSIVE EFFECTS OF ARGININE DEIMINASE FROM STREPTOCOCCUS PYOGENES
title_short	IMMUNOSUPPRESSIVE EFFECTS OF ARGININE DEIMINASE FROM STREPTOCOCCUS PYOGENES
title_full	IMMUNOSUPPRESSIVE EFFECTS OF ARGININE DEIMINASE FROM STREPTOCOCCUS PYOGENES
title_fullStr	IMMUNOSUPPRESSIVE EFFECTS OF ARGININE DEIMINASE FROM STREPTOCOCCUS PYOGENES
title_full_unstemmed	IMMUNOSUPPRESSIVE EFFECTS OF ARGININE DEIMINASE FROM STREPTOCOCCUS PYOGENES
title_sort	immunosuppressive effects of arginine deiminase from streptococcus pyogenes
publisher	SPb RAACI
publishDate	2015
url	https://doaj.org/article/44e07b72652e4e4a824a251de0ea5a3c
work_keys_str_mv	AT eastarikova immunosuppressiveeffectsofargininedeiminasefromstreptococcuspyogenes AT avsokolov immunosuppressiveeffectsofargininedeiminasefromstreptococcuspyogenes AT laburova immunosuppressiveeffectsofargininedeiminasefromstreptococcuspyogenes AT isfreidlin immunosuppressiveeffectsofargininedeiminasefromstreptococcuspyogenes
_version_	1718422412791382016

IMMUNOSUPPRESSIVE EFFECTS OF ARGININE DEIMINASE FROM STREPTOCOCCUS PYOGENES

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