Ultrasonographic characteristics of major salivary glands in anti-centromere antibody-positive primary Sjögren's syndrome.

<h4>Purpose</h4>To investigate salivary gland ultrasonography (SGUS) findings in primary Sjögren's syndrome (pSS) patients positive for the anti-centromere antibody (ACA) and compare these with those in ACA-negative pSS patients.<h4>Methods</h4>We analyzed demographic, c...

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Autores principales:	Hong Ki Min, Se-Hee Kim, Youngjae Park, Kyung-Ann Lee, Seung-Ki Kwok, Sang-Heon Lee, Hae-Rim Kim
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/44e0faa90d3548759b5484e555e9557a
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spelling	oai:doaj.org-article:44e0faa90d3548759b5484e555e9557a2021-12-02T20:04:27ZUltrasonographic characteristics of major salivary glands in anti-centromere antibody-positive primary Sjögren's syndrome.1932-620310.1371/journal.pone.0259519https://doaj.org/article/44e0faa90d3548759b5484e555e9557a2021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0259519https://doaj.org/toc/1932-6203<h4>Purpose</h4>To investigate salivary gland ultrasonography (SGUS) findings in primary Sjögren's syndrome (pSS) patients positive for the anti-centromere antibody (ACA) and compare these with those in ACA-negative pSS patients.<h4>Methods</h4>We analyzed demographic, clinical, laboratory, and SGUS data of pSS patients who fulfilled the 2002 American-European Consensus Group classification criteria for pSS. SGUS findings of four major salivary glands (bilateral parotid and submandibular glands) were scored in five categories and compared between ACA-positive and ACA-negative pSS patients. Linear regression analysis was performed to elucidate the factors associated with SGUS score.<h4>Results</h4>In total, 121 pSS patients were enrolled (19, ACA-positive). The ACA-positive patients were older (67.0 vs 58.0 years, P = 0.028), whereas anti-Ro/SSA and anti-La/SSB positivity was more prevalent in the ACA-negative group (89.2% vs 21.1%, P < 0.001, and 47.1% vs 10.5%, P = 0.007, respectively). The total SGUS and hypoechoic area scores were lower in ACA-positive patients (16.0 vs 23.0, P = 0.027, and 4.0 vs 7.0, P = 0.004, respectively). In univariate regression analysis, being positive for unstimulated salivary flow rate (USFR < 1.5 ml/15 min), anti-Ro/SSA, and rheumatoid factor were positively associated whereas ACA positivity was negatively associated with the SGUS score. In multivariate regression analysis, being positive for USFR, anti-Ro/SSA, and rheumatoid factor showed significant association with the SGUS score.<h4>Conclusions</h4>ACA-positive pSS patients showed a lower SGUS score than ACA-negative patients, which was especially prominent in the hypoechoic area component.Hong Ki MinSe-Hee KimYoungjae ParkKyung-Ann LeeSeung-Ki KwokSang-Heon LeeHae-Rim KimPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 11, p e0259519 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hong Ki Min Se-Hee Kim Youngjae Park Kyung-Ann Lee Seung-Ki Kwok Sang-Heon Lee Hae-Rim Kim Ultrasonographic characteristics of major salivary glands in anti-centromere antibody-positive primary Sjögren's syndrome.
description	<h4>Purpose</h4>To investigate salivary gland ultrasonography (SGUS) findings in primary Sjögren's syndrome (pSS) patients positive for the anti-centromere antibody (ACA) and compare these with those in ACA-negative pSS patients.<h4>Methods</h4>We analyzed demographic, clinical, laboratory, and SGUS data of pSS patients who fulfilled the 2002 American-European Consensus Group classification criteria for pSS. SGUS findings of four major salivary glands (bilateral parotid and submandibular glands) were scored in five categories and compared between ACA-positive and ACA-negative pSS patients. Linear regression analysis was performed to elucidate the factors associated with SGUS score.<h4>Results</h4>In total, 121 pSS patients were enrolled (19, ACA-positive). The ACA-positive patients were older (67.0 vs 58.0 years, P = 0.028), whereas anti-Ro/SSA and anti-La/SSB positivity was more prevalent in the ACA-negative group (89.2% vs 21.1%, P < 0.001, and 47.1% vs 10.5%, P = 0.007, respectively). The total SGUS and hypoechoic area scores were lower in ACA-positive patients (16.0 vs 23.0, P = 0.027, and 4.0 vs 7.0, P = 0.004, respectively). In univariate regression analysis, being positive for unstimulated salivary flow rate (USFR < 1.5 ml/15 min), anti-Ro/SSA, and rheumatoid factor were positively associated whereas ACA positivity was negatively associated with the SGUS score. In multivariate regression analysis, being positive for USFR, anti-Ro/SSA, and rheumatoid factor showed significant association with the SGUS score.<h4>Conclusions</h4>ACA-positive pSS patients showed a lower SGUS score than ACA-negative patients, which was especially prominent in the hypoechoic area component.
format	article
author	Hong Ki Min Se-Hee Kim Youngjae Park Kyung-Ann Lee Seung-Ki Kwok Sang-Heon Lee Hae-Rim Kim
author_facet	Hong Ki Min Se-Hee Kim Youngjae Park Kyung-Ann Lee Seung-Ki Kwok Sang-Heon Lee Hae-Rim Kim
author_sort	Hong Ki Min
title	Ultrasonographic characteristics of major salivary glands in anti-centromere antibody-positive primary Sjögren's syndrome.
title_short	Ultrasonographic characteristics of major salivary glands in anti-centromere antibody-positive primary Sjögren's syndrome.
title_full	Ultrasonographic characteristics of major salivary glands in anti-centromere antibody-positive primary Sjögren's syndrome.
title_fullStr	Ultrasonographic characteristics of major salivary glands in anti-centromere antibody-positive primary Sjögren's syndrome.
title_full_unstemmed	Ultrasonographic characteristics of major salivary glands in anti-centromere antibody-positive primary Sjögren's syndrome.
title_sort	ultrasonographic characteristics of major salivary glands in anti-centromere antibody-positive primary sjögren's syndrome.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/44e0faa90d3548759b5484e555e9557a
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Ultrasonographic characteristics of major salivary glands in anti-centromere antibody-positive primary Sjögren's syndrome.

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