Severe but Self-Limiting Polyarthralgia with Functional Impairment Following ChAdOx1 nCov-19 Vaccination in an Elderly Recipient

A 79-year-old female patient with no pre-existing rheumatological conditions presented with severe functional impairment secondary to polyarthralgia, most likely an adverse reaction following her first dose of Oxford/AstraZeneca ChAdOx1 nCov-19 vaccination against SARS-CoV-2, the causative agent of...

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Autores principales:	Joel Ern Zher Chan, Anand Irimpen
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	COVID-19 SARS-CoV-2 vaccine Oxford/AstraZeneca ChAdOx1 nCov-19 elderly patient Medicine R
Acceso en línea:	https://doaj.org/article/44e1a5c7e89d41f39c0d3c9ab3828e6e
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spelling	oai:doaj.org-article:44e1a5c7e89d41f39c0d3c9ab3828e6e2021-11-25T19:10:09ZSevere but Self-Limiting Polyarthralgia with Functional Impairment Following ChAdOx1 nCov-19 Vaccination in an Elderly Recipient10.3390/vaccines91112202076-393Xhttps://doaj.org/article/44e1a5c7e89d41f39c0d3c9ab3828e6e2021-10-01T00:00:00Zhttps://www.mdpi.com/2076-393X/9/11/1220https://doaj.org/toc/2076-393XA 79-year-old female patient with no pre-existing rheumatological conditions presented with severe functional impairment secondary to polyarthralgia, most likely an adverse reaction following her first dose of Oxford/AstraZeneca ChAdOx1 nCov-19 vaccination against SARS-CoV-2, the causative agent of Coronavirus Disease 2019 (COVID-19). The presentation mimicked clinical features of polymyalgia rheumatica and was distinctive in its pattern and delayed onset. Its severity in an elderly patient was significant against trial findings of decreasing reactogenicity of ChAdOx1 nCov-19 vaccine with increasing age, and traumatic to the patient. Acute phase reactants were elevated, consistent with recent similar reports among mostly elderly, female patients. New onset rheumatological conditions and flares of pre-existing, well-controlled conditions had been well established in COVID-19 and, to a lesser extent, post-vaccination. Viral arthralgias as a distinct clinical entity in COVID-19 is only beginning to be recognized. It could be that this case report represents a similar entity which occurs following vaccination against SARS-CoV-2. Despite this, the benefits of vaccination continue to outweigh such risks, although this case report is important for providing understanding of clinical progression when such reactions occur, aiding in patient discussions and clinical decisions to weigh up further investigations or empirical treatment against reassurance and close monitoring.Joel Ern Zher ChanAnand IrimpenMDPI AGarticleCOVID-19SARS-CoV-2vaccineOxford/AstraZenecaChAdOx1 nCov-19elderly patientMedicineRENVaccines, Vol 9, Iss 1220, p 1220 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	COVID-19 SARS-CoV-2 vaccine Oxford/AstraZeneca ChAdOx1 nCov-19 elderly patient Medicine R
spellingShingle	COVID-19 SARS-CoV-2 vaccine Oxford/AstraZeneca ChAdOx1 nCov-19 elderly patient Medicine R Joel Ern Zher Chan Anand Irimpen Severe but Self-Limiting Polyarthralgia with Functional Impairment Following ChAdOx1 nCov-19 Vaccination in an Elderly Recipient
description	A 79-year-old female patient with no pre-existing rheumatological conditions presented with severe functional impairment secondary to polyarthralgia, most likely an adverse reaction following her first dose of Oxford/AstraZeneca ChAdOx1 nCov-19 vaccination against SARS-CoV-2, the causative agent of Coronavirus Disease 2019 (COVID-19). The presentation mimicked clinical features of polymyalgia rheumatica and was distinctive in its pattern and delayed onset. Its severity in an elderly patient was significant against trial findings of decreasing reactogenicity of ChAdOx1 nCov-19 vaccine with increasing age, and traumatic to the patient. Acute phase reactants were elevated, consistent with recent similar reports among mostly elderly, female patients. New onset rheumatological conditions and flares of pre-existing, well-controlled conditions had been well established in COVID-19 and, to a lesser extent, post-vaccination. Viral arthralgias as a distinct clinical entity in COVID-19 is only beginning to be recognized. It could be that this case report represents a similar entity which occurs following vaccination against SARS-CoV-2. Despite this, the benefits of vaccination continue to outweigh such risks, although this case report is important for providing understanding of clinical progression when such reactions occur, aiding in patient discussions and clinical decisions to weigh up further investigations or empirical treatment against reassurance and close monitoring.
format	article
author	Joel Ern Zher Chan Anand Irimpen
author_facet	Joel Ern Zher Chan Anand Irimpen
author_sort	Joel Ern Zher Chan
title	Severe but Self-Limiting Polyarthralgia with Functional Impairment Following ChAdOx1 nCov-19 Vaccination in an Elderly Recipient
title_short	Severe but Self-Limiting Polyarthralgia with Functional Impairment Following ChAdOx1 nCov-19 Vaccination in an Elderly Recipient
title_full	Severe but Self-Limiting Polyarthralgia with Functional Impairment Following ChAdOx1 nCov-19 Vaccination in an Elderly Recipient
title_fullStr	Severe but Self-Limiting Polyarthralgia with Functional Impairment Following ChAdOx1 nCov-19 Vaccination in an Elderly Recipient
title_full_unstemmed	Severe but Self-Limiting Polyarthralgia with Functional Impairment Following ChAdOx1 nCov-19 Vaccination in an Elderly Recipient
title_sort	severe but self-limiting polyarthralgia with functional impairment following chadox1 ncov-19 vaccination in an elderly recipient
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/44e1a5c7e89d41f39c0d3c9ab3828e6e
work_keys_str_mv	AT joelernzherchan severebutselflimitingpolyarthralgiawithfunctionalimpairmentfollowingchadox1ncov19vaccinationinanelderlyrecipient AT anandirimpen severebutselflimitingpolyarthralgiawithfunctionalimpairmentfollowingchadox1ncov19vaccinationinanelderlyrecipient
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Severe but Self-Limiting Polyarthralgia with Functional Impairment Following ChAdOx1 nCov-19 Vaccination in an Elderly Recipient

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