Effect of Tongluozhitong Prescription-Assisted Intra-Articular Injection of Sodium Hyaluronate on VAS Score and Knee Lysholm Score in Patients with Knee Osteoarthritis

Knee osteoarthritis (KOA) has become one of the leading causes of workforce loss in the middle-aged and elderly population and a global public health problem second only to cardiovascular disease, so we need to find more effective treatments for this disease. In this study, we selected 120 patients...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Jianfang Gong, Qiang Li, Mengling Wei, Liangliang Xue, Yinlian Liu, Jun Gao, Tiantian Qin
Formato:	article
Lenguaje:	EN
Publicado:	Hindawi Limited 2021
Materias:	Other systems of medicine RZ201-999
Acceso en línea:	https://doaj.org/article/44e25593ee094a31b5bb7078d1548973
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:44e25593ee094a31b5bb7078d1548973
record_format	dspace
spelling	oai:doaj.org-article:44e25593ee094a31b5bb7078d15489732021-11-08T02:35:45ZEffect of Tongluozhitong Prescription-Assisted Intra-Articular Injection of Sodium Hyaluronate on VAS Score and Knee Lysholm Score in Patients with Knee Osteoarthritis1741-428810.1155/2021/3210494https://doaj.org/article/44e25593ee094a31b5bb7078d15489732021-01-01T00:00:00Zhttp://dx.doi.org/10.1155/2021/3210494https://doaj.org/toc/1741-4288Knee osteoarthritis (KOA) has become one of the leading causes of workforce loss in the middle-aged and elderly population and a global public health problem second only to cardiovascular disease, so we need to find more effective treatments for this disease. In this study, we selected 120 patients with KOA admitted to our hospital from June 2018 to December 2020 and divided them into treatment group 1, treatment group 2, and joint group according to the random number table method, with 40 patients in each group. Treatment group 1 was treated with Tongluozhitong prescription dip-soaking therapy, treatment 2 group was treated with intra-articular injection of sodium hyaluronate, and the joint group was treated with a combination of both modalities for 4 weeks in all three groups. Clinical efficacy, visual analogue scale (VAS), Lysholm knee score (LKS), activity of daily living score (ADL), the levels of bone metabolic markers such as cartilage oligomeric matrix protein (COMP), type II collagen degradation maker (CTX-II), and matrix metalloproteinase-3 (MMP-3), and the levels of inflammatory mediators such as interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α), and hypersensitive C-reactive protein (hs-CRP) were used as observations to compare and analyze the therapeutic effects of the three treatment regimens in KOA patients. The results showed that the clinical excellence rates of the joint group, treatment group 1, and treatment group 2 were 72.50%, 50.00%, and 90.00%, respectively, with statistically significant differences between any two comparisons. After treatment, VAS scores, serum COMP, CTX-II, MMP-3, IL-1β, TNF-α, and hs-CRP levels decreased in all three groups, and the levels of each index were as follows: joint group < treatment group 1 < treatment group 2, and the difference between any two comparisons was statistically significant. The LKS score and ADL score increased in all three groups, and the levels of each index were as follows: joint group > treatment group 1 > treatment group 2, with statistically significant differences in any two groups compared. None of the patients in the three groups experienced any significant adverse effects during treatment. This suggests that the dip-soaking therapy of Tongluozhitong prescription is more advantageous than intra-articular sodium hyaluronate injection treatment in suppressing the level of serum bone metabolic markers and inflammatory mediators, reducing pathological joint damage, relieving symptoms of pain, alleviating degenerative joint symptoms, and improving knee function in KOA patients. The combination of the two in KOA patients can significantly improve the efficacy and has a good safety profile.Jianfang GongQiang LiMengling WeiLiangliang XueYinlian LiuJun GaoTiantian QinHindawi LimitedarticleOther systems of medicineRZ201-999ENEvidence-Based Complementary and Alternative Medicine, Vol 2021 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Other systems of medicine RZ201-999
spellingShingle	Other systems of medicine RZ201-999 Jianfang Gong Qiang Li Mengling Wei Liangliang Xue Yinlian Liu Jun Gao Tiantian Qin Effect of Tongluozhitong Prescription-Assisted Intra-Articular Injection of Sodium Hyaluronate on VAS Score and Knee Lysholm Score in Patients with Knee Osteoarthritis
description	Knee osteoarthritis (KOA) has become one of the leading causes of workforce loss in the middle-aged and elderly population and a global public health problem second only to cardiovascular disease, so we need to find more effective treatments for this disease. In this study, we selected 120 patients with KOA admitted to our hospital from June 2018 to December 2020 and divided them into treatment group 1, treatment group 2, and joint group according to the random number table method, with 40 patients in each group. Treatment group 1 was treated with Tongluozhitong prescription dip-soaking therapy, treatment 2 group was treated with intra-articular injection of sodium hyaluronate, and the joint group was treated with a combination of both modalities for 4 weeks in all three groups. Clinical efficacy, visual analogue scale (VAS), Lysholm knee score (LKS), activity of daily living score (ADL), the levels of bone metabolic markers such as cartilage oligomeric matrix protein (COMP), type II collagen degradation maker (CTX-II), and matrix metalloproteinase-3 (MMP-3), and the levels of inflammatory mediators such as interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α), and hypersensitive C-reactive protein (hs-CRP) were used as observations to compare and analyze the therapeutic effects of the three treatment regimens in KOA patients. The results showed that the clinical excellence rates of the joint group, treatment group 1, and treatment group 2 were 72.50%, 50.00%, and 90.00%, respectively, with statistically significant differences between any two comparisons. After treatment, VAS scores, serum COMP, CTX-II, MMP-3, IL-1β, TNF-α, and hs-CRP levels decreased in all three groups, and the levels of each index were as follows: joint group < treatment group 1 < treatment group 2, and the difference between any two comparisons was statistically significant. The LKS score and ADL score increased in all three groups, and the levels of each index were as follows: joint group > treatment group 1 > treatment group 2, with statistically significant differences in any two groups compared. None of the patients in the three groups experienced any significant adverse effects during treatment. This suggests that the dip-soaking therapy of Tongluozhitong prescription is more advantageous than intra-articular sodium hyaluronate injection treatment in suppressing the level of serum bone metabolic markers and inflammatory mediators, reducing pathological joint damage, relieving symptoms of pain, alleviating degenerative joint symptoms, and improving knee function in KOA patients. The combination of the two in KOA patients can significantly improve the efficacy and has a good safety profile.
format	article
author	Jianfang Gong Qiang Li Mengling Wei Liangliang Xue Yinlian Liu Jun Gao Tiantian Qin
author_facet	Jianfang Gong Qiang Li Mengling Wei Liangliang Xue Yinlian Liu Jun Gao Tiantian Qin
author_sort	Jianfang Gong
title	Effect of Tongluozhitong Prescription-Assisted Intra-Articular Injection of Sodium Hyaluronate on VAS Score and Knee Lysholm Score in Patients with Knee Osteoarthritis
title_short	Effect of Tongluozhitong Prescription-Assisted Intra-Articular Injection of Sodium Hyaluronate on VAS Score and Knee Lysholm Score in Patients with Knee Osteoarthritis
title_full	Effect of Tongluozhitong Prescription-Assisted Intra-Articular Injection of Sodium Hyaluronate on VAS Score and Knee Lysholm Score in Patients with Knee Osteoarthritis
title_fullStr	Effect of Tongluozhitong Prescription-Assisted Intra-Articular Injection of Sodium Hyaluronate on VAS Score and Knee Lysholm Score in Patients with Knee Osteoarthritis
title_full_unstemmed	Effect of Tongluozhitong Prescription-Assisted Intra-Articular Injection of Sodium Hyaluronate on VAS Score and Knee Lysholm Score in Patients with Knee Osteoarthritis
title_sort	effect of tongluozhitong prescription-assisted intra-articular injection of sodium hyaluronate on vas score and knee lysholm score in patients with knee osteoarthritis
publisher	Hindawi Limited
publishDate	2021
url	https://doaj.org/article/44e25593ee094a31b5bb7078d1548973
work_keys_str_mv	AT jianfanggong effectoftongluozhitongprescriptionassistedintraarticularinjectionofsodiumhyaluronateonvasscoreandkneelysholmscoreinpatientswithkneeosteoarthritis AT qiangli effectoftongluozhitongprescriptionassistedintraarticularinjectionofsodiumhyaluronateonvasscoreandkneelysholmscoreinpatientswithkneeosteoarthritis AT menglingwei effectoftongluozhitongprescriptionassistedintraarticularinjectionofsodiumhyaluronateonvasscoreandkneelysholmscoreinpatientswithkneeosteoarthritis AT liangliangxue effectoftongluozhitongprescriptionassistedintraarticularinjectionofsodiumhyaluronateonvasscoreandkneelysholmscoreinpatientswithkneeosteoarthritis AT yinlianliu effectoftongluozhitongprescriptionassistedintraarticularinjectionofsodiumhyaluronateonvasscoreandkneelysholmscoreinpatientswithkneeosteoarthritis AT jungao effectoftongluozhitongprescriptionassistedintraarticularinjectionofsodiumhyaluronateonvasscoreandkneelysholmscoreinpatientswithkneeosteoarthritis AT tiantianqin effectoftongluozhitongprescriptionassistedintraarticularinjectionofsodiumhyaluronateonvasscoreandkneelysholmscoreinpatientswithkneeosteoarthritis
_version_	1718443178644733952

Effect of Tongluozhitong Prescription-Assisted Intra-Articular Injection of Sodium Hyaluronate on VAS Score and Knee Lysholm Score in Patients with Knee Osteoarthritis

Ejemplares similares