Immunobiological Properties and Clinical Applications of Interleukin-38 for Immune-Mediated Disorders: A Systematic Review Study

Exponential growth in the usage of “cytokines” (as seroimmunobiomarkers) has facilitated more accurate prognosis, early diagnosis, novel, and efficient immunotherapeutics. Numerous studies have reported immunopathophysiological and immunopathological processes of interleukin-38 (IL-38). Therefore, i...

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Autores principales:	Abdolreza Esmaeilzadeh, Nazila Bahmaie, Elham Nouri, Mohammad Javad Hajkazemi, Maryam Zareh Rafie
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	biomarker clinical applications diagnosis immunobiology immunopathophysiology interleukin-38 Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/44e3511289e04bfba45430a6360a3900
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spelling	oai:doaj.org-article:44e3511289e04bfba45430a6360a39002021-11-25T17:57:45ZImmunobiological Properties and Clinical Applications of Interleukin-38 for Immune-Mediated Disorders: A Systematic Review Study10.3390/ijms2222125521422-00671661-6596https://doaj.org/article/44e3511289e04bfba45430a6360a39002021-11-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/22/12552https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067Exponential growth in the usage of “cytokines” (as seroimmunobiomarkers) has facilitated more accurate prognosis, early diagnosis, novel, and efficient immunotherapeutics. Numerous studies have reported immunopathophysiological and immunopathological processes of interleukin-38 (IL-38). Therefore, in this systematic review article, the authors aimed to present an updated comprehensive overview on the immunobiological mechanisms, diagnostic, and immune gene-based therapeutic potentials of IL-38. According to our inclusion and exclusion criteria, a total of 216 articles were collected from several search engines and databases from the January 2012 to July 2021 time interval by using six main keywords. Physiologic or pathologic microenvironments, optimal dosage, and involved receptors affect the functionalities of IL-38. Alterations in serum levels of IL-38 play a major role in the immunopathogenesis of a wide array of immune-mediated disorders. IL-38 shows anti-inflammatory activities by reduction or inhibition of pro-inflammatory cytokines, supporting the therapeutic aspects of IL-38 in inflammatory autoimmune diseases. According to the importance of pre-clinical studies, it seems that manipulation of the immune system by immunomodulatory properties of IL-38 can increase the accuracy of diagnosis, and decipher optimal clinical outcomes. To promote our knowledge, more collaboration is highly recommended among laboratory scientists, internal/infectious diseases specialists, oncologists, immunologists, diseases-specific biomarkers scientists, and basic medical researchers.Abdolreza EsmaeilzadehNazila BahmaieElham NouriMohammad Javad HajkazemiMaryam Zareh RafieMDPI AGarticlebiomarkerclinical applicationsdiagnosisimmunobiologyimmunopathophysiologyinterleukin-38Biology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 12552, p 12552 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	biomarker clinical applications diagnosis immunobiology immunopathophysiology interleukin-38 Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	biomarker clinical applications diagnosis immunobiology immunopathophysiology interleukin-38 Biology (General) QH301-705.5 Chemistry QD1-999 Abdolreza Esmaeilzadeh Nazila Bahmaie Elham Nouri Mohammad Javad Hajkazemi Maryam Zareh Rafie Immunobiological Properties and Clinical Applications of Interleukin-38 for Immune-Mediated Disorders: A Systematic Review Study
description	Exponential growth in the usage of “cytokines” (as seroimmunobiomarkers) has facilitated more accurate prognosis, early diagnosis, novel, and efficient immunotherapeutics. Numerous studies have reported immunopathophysiological and immunopathological processes of interleukin-38 (IL-38). Therefore, in this systematic review article, the authors aimed to present an updated comprehensive overview on the immunobiological mechanisms, diagnostic, and immune gene-based therapeutic potentials of IL-38. According to our inclusion and exclusion criteria, a total of 216 articles were collected from several search engines and databases from the January 2012 to July 2021 time interval by using six main keywords. Physiologic or pathologic microenvironments, optimal dosage, and involved receptors affect the functionalities of IL-38. Alterations in serum levels of IL-38 play a major role in the immunopathogenesis of a wide array of immune-mediated disorders. IL-38 shows anti-inflammatory activities by reduction or inhibition of pro-inflammatory cytokines, supporting the therapeutic aspects of IL-38 in inflammatory autoimmune diseases. According to the importance of pre-clinical studies, it seems that manipulation of the immune system by immunomodulatory properties of IL-38 can increase the accuracy of diagnosis, and decipher optimal clinical outcomes. To promote our knowledge, more collaboration is highly recommended among laboratory scientists, internal/infectious diseases specialists, oncologists, immunologists, diseases-specific biomarkers scientists, and basic medical researchers.
format	article
author	Abdolreza Esmaeilzadeh Nazila Bahmaie Elham Nouri Mohammad Javad Hajkazemi Maryam Zareh Rafie
author_facet	Abdolreza Esmaeilzadeh Nazila Bahmaie Elham Nouri Mohammad Javad Hajkazemi Maryam Zareh Rafie
author_sort	Abdolreza Esmaeilzadeh
title	Immunobiological Properties and Clinical Applications of Interleukin-38 for Immune-Mediated Disorders: A Systematic Review Study
title_short	Immunobiological Properties and Clinical Applications of Interleukin-38 for Immune-Mediated Disorders: A Systematic Review Study
title_full	Immunobiological Properties and Clinical Applications of Interleukin-38 for Immune-Mediated Disorders: A Systematic Review Study
title_fullStr	Immunobiological Properties and Clinical Applications of Interleukin-38 for Immune-Mediated Disorders: A Systematic Review Study
title_full_unstemmed	Immunobiological Properties and Clinical Applications of Interleukin-38 for Immune-Mediated Disorders: A Systematic Review Study
title_sort	immunobiological properties and clinical applications of interleukin-38 for immune-mediated disorders: a systematic review study
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/44e3511289e04bfba45430a6360a3900
work_keys_str_mv	AT abdolrezaesmaeilzadeh immunobiologicalpropertiesandclinicalapplicationsofinterleukin38forimmunemediateddisordersasystematicreviewstudy AT nazilabahmaie immunobiologicalpropertiesandclinicalapplicationsofinterleukin38forimmunemediateddisordersasystematicreviewstudy AT elhamnouri immunobiologicalpropertiesandclinicalapplicationsofinterleukin38forimmunemediateddisordersasystematicreviewstudy AT mohammadjavadhajkazemi immunobiologicalpropertiesandclinicalapplicationsofinterleukin38forimmunemediateddisordersasystematicreviewstudy AT maryamzarehrafie immunobiologicalpropertiesandclinicalapplicationsofinterleukin38forimmunemediateddisordersasystematicreviewstudy
_version_	1718411798155100160

Immunobiological Properties and Clinical Applications of Interleukin-38 for Immune-Mediated Disorders: A Systematic Review Study

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