European bone mineral density loci are also associated with BMD in East-Asian populations.

Most genome-wide association (GWA) studies have focused on populations of European ancestry with limited assessment of the influence of the sequence variants on populations of other ethnicities. To determine whether markers that we have recently shown to associate with Bone Mineral Density (BMD) in...

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Autores principales:	Unnur Styrkarsdottir, Bjarni V Halldorsson, Daniel F Gudbjartsson, Nelson L S Tang, Jung-Min Koh, Su-mei Xiao, Timothy C Y Kwok, Ghi Su Kim, Juliana C N Chan, Stacey Cherny, Seung Hun Lee, Anthony Kwok, Suzanne Ho, Solveig Gretarsdottir, Jelena Pop Kostic, Stefan Th Palsson, Gunnar Sigurdsson, Pak C Sham, Beom-Jun Kim, Annie W C Kung, Shin-Yoon Kim, Jean Woo, Ping-C Leung, Augustine Kong, Unnur Thorsteinsdottir, Kari Stefansson
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2010
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/44e7288dec2e43d594ef3b81b80d90ae
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spelling	oai:doaj.org-article:44e7288dec2e43d594ef3b81b80d90ae2021-11-18T07:03:34ZEuropean bone mineral density loci are also associated with BMD in East-Asian populations.1932-620310.1371/journal.pone.0013217https://doaj.org/article/44e7288dec2e43d594ef3b81b80d90ae2010-10-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20949110/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Most genome-wide association (GWA) studies have focused on populations of European ancestry with limited assessment of the influence of the sequence variants on populations of other ethnicities. To determine whether markers that we have recently shown to associate with Bone Mineral Density (BMD) in Europeans also associate with BMD in East-Asians we analysed 50 markers from 23 genomic loci in samples from Korea (n = 1,397) and two Chinese Hong Kong sample sets (n = 3,869 and n = 785). Through this effort we identified fourteen loci that associated with BMD in East-Asian samples using a false discovery rate (FDR) of 0.05; 1p36 (ZBTB40, P = 4.3×10(-9)), 1p31 (GPR177, P = 0.00012), 3p22 (CTNNB1, P = 0.00013), 4q22 (MEPE, P = 0.0026), 5q14 (MEF2C, P = 1.3×10(-5)), 6q25 (ESR1, P = 0.0011), 7p14 (STARD3NL, P = 0.00025), 7q21 (FLJ42280, P = 0.00017), 8q24 (TNFRSF11B, P = 3.4×10(-5)), 11p15 (SOX6, P = 0.00033), 11q13 (LRP5, P = 0.0033), 13q14 (TNFSF11, P = 7.5×10(-5)), 16q24 (FOXL1, P = 0.0010) and 17q21 (SOST, P = 0.015). Our study marks an early effort towards the challenge of cataloguing bone density variants shared by many ethnicities by testing BMD variants that have been established in Europeans, in East-Asians.Unnur StyrkarsdottirBjarni V HalldorssonDaniel F GudbjartssonNelson L S TangJung-Min KohSu-mei XiaoTimothy C Y KwokGhi Su KimJuliana C N ChanStacey ChernySeung Hun LeeAnthony KwokSuzanne HoSolveig GretarsdottirJelena Pop KosticStefan Th PalssonGunnar SigurdssonPak C ShamBeom-Jun KimAnnie W C KungShin-Yoon KimJean WooPing-C LeungAugustine KongUnnur ThorsteinsdottirKari StefanssonPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 5, Iss 10, p e13217 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Unnur Styrkarsdottir Bjarni V Halldorsson Daniel F Gudbjartsson Nelson L S Tang Jung-Min Koh Su-mei Xiao Timothy C Y Kwok Ghi Su Kim Juliana C N Chan Stacey Cherny Seung Hun Lee Anthony Kwok Suzanne Ho Solveig Gretarsdottir Jelena Pop Kostic Stefan Th Palsson Gunnar Sigurdsson Pak C Sham Beom-Jun Kim Annie W C Kung Shin-Yoon Kim Jean Woo Ping-C Leung Augustine Kong Unnur Thorsteinsdottir Kari Stefansson European bone mineral density loci are also associated with BMD in East-Asian populations.
description	Most genome-wide association (GWA) studies have focused on populations of European ancestry with limited assessment of the influence of the sequence variants on populations of other ethnicities. To determine whether markers that we have recently shown to associate with Bone Mineral Density (BMD) in Europeans also associate with BMD in East-Asians we analysed 50 markers from 23 genomic loci in samples from Korea (n = 1,397) and two Chinese Hong Kong sample sets (n = 3,869 and n = 785). Through this effort we identified fourteen loci that associated with BMD in East-Asian samples using a false discovery rate (FDR) of 0.05; 1p36 (ZBTB40, P = 4.3×10(-9)), 1p31 (GPR177, P = 0.00012), 3p22 (CTNNB1, P = 0.00013), 4q22 (MEPE, P = 0.0026), 5q14 (MEF2C, P = 1.3×10(-5)), 6q25 (ESR1, P = 0.0011), 7p14 (STARD3NL, P = 0.00025), 7q21 (FLJ42280, P = 0.00017), 8q24 (TNFRSF11B, P = 3.4×10(-5)), 11p15 (SOX6, P = 0.00033), 11q13 (LRP5, P = 0.0033), 13q14 (TNFSF11, P = 7.5×10(-5)), 16q24 (FOXL1, P = 0.0010) and 17q21 (SOST, P = 0.015). Our study marks an early effort towards the challenge of cataloguing bone density variants shared by many ethnicities by testing BMD variants that have been established in Europeans, in East-Asians.
format	article
author	Unnur Styrkarsdottir Bjarni V Halldorsson Daniel F Gudbjartsson Nelson L S Tang Jung-Min Koh Su-mei Xiao Timothy C Y Kwok Ghi Su Kim Juliana C N Chan Stacey Cherny Seung Hun Lee Anthony Kwok Suzanne Ho Solveig Gretarsdottir Jelena Pop Kostic Stefan Th Palsson Gunnar Sigurdsson Pak C Sham Beom-Jun Kim Annie W C Kung Shin-Yoon Kim Jean Woo Ping-C Leung Augustine Kong Unnur Thorsteinsdottir Kari Stefansson
author_facet	Unnur Styrkarsdottir Bjarni V Halldorsson Daniel F Gudbjartsson Nelson L S Tang Jung-Min Koh Su-mei Xiao Timothy C Y Kwok Ghi Su Kim Juliana C N Chan Stacey Cherny Seung Hun Lee Anthony Kwok Suzanne Ho Solveig Gretarsdottir Jelena Pop Kostic Stefan Th Palsson Gunnar Sigurdsson Pak C Sham Beom-Jun Kim Annie W C Kung Shin-Yoon Kim Jean Woo Ping-C Leung Augustine Kong Unnur Thorsteinsdottir Kari Stefansson
author_sort	Unnur Styrkarsdottir
title	European bone mineral density loci are also associated with BMD in East-Asian populations.
title_short	European bone mineral density loci are also associated with BMD in East-Asian populations.
title_full	European bone mineral density loci are also associated with BMD in East-Asian populations.
title_fullStr	European bone mineral density loci are also associated with BMD in East-Asian populations.
title_full_unstemmed	European bone mineral density loci are also associated with BMD in East-Asian populations.
title_sort	european bone mineral density loci are also associated with bmd in east-asian populations.
publisher	Public Library of Science (PLoS)
publishDate	2010
url	https://doaj.org/article/44e7288dec2e43d594ef3b81b80d90ae
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European bone mineral density loci are also associated with BMD in East-Asian populations.

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