Single-cell analysis reveals new evolutionary complexity in uveal melanoma

Uveal melanoma is highly metastatic and unresponsive to checkpoint immunotherapy. Here, the authors present single-cell transcriptomics of 59,915 cells in 8 primary and 3 metastatic samples, highlighting the diversity of the tumour microenvironment.

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Autores principales:	Michael A. Durante, Daniel A. Rodriguez, Stefan Kurtenbach, Jeffim N. Kuznetsov, Margaret I. Sanchez, Christina L. Decatur, Helen Snyder, Lynn G. Feun, Alan S. Livingstone, J. William Harbour
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/44e8def81b794cf189b9ab19348ac21d
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spelling	oai:doaj.org-article:44e8def81b794cf189b9ab19348ac21d2021-12-02T15:33:52ZSingle-cell analysis reveals new evolutionary complexity in uveal melanoma10.1038/s41467-019-14256-12041-1723https://doaj.org/article/44e8def81b794cf189b9ab19348ac21d2020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-14256-1https://doaj.org/toc/2041-1723Uveal melanoma is highly metastatic and unresponsive to checkpoint immunotherapy. Here, the authors present single-cell transcriptomics of 59,915 cells in 8 primary and 3 metastatic samples, highlighting the diversity of the tumour microenvironment.Michael A. DuranteDaniel A. RodriguezStefan KurtenbachJeffim N. KuznetsovMargaret I. SanchezChristina L. DecaturHelen SnyderLynn G. FeunAlan S. LivingstoneJ. William HarbourNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Michael A. Durante Daniel A. Rodriguez Stefan Kurtenbach Jeffim N. Kuznetsov Margaret I. Sanchez Christina L. Decatur Helen Snyder Lynn G. Feun Alan S. Livingstone J. William Harbour Single-cell analysis reveals new evolutionary complexity in uveal melanoma
description	Uveal melanoma is highly metastatic and unresponsive to checkpoint immunotherapy. Here, the authors present single-cell transcriptomics of 59,915 cells in 8 primary and 3 metastatic samples, highlighting the diversity of the tumour microenvironment.
format	article
author	Michael A. Durante Daniel A. Rodriguez Stefan Kurtenbach Jeffim N. Kuznetsov Margaret I. Sanchez Christina L. Decatur Helen Snyder Lynn G. Feun Alan S. Livingstone J. William Harbour
author_facet	Michael A. Durante Daniel A. Rodriguez Stefan Kurtenbach Jeffim N. Kuznetsov Margaret I. Sanchez Christina L. Decatur Helen Snyder Lynn G. Feun Alan S. Livingstone J. William Harbour
author_sort	Michael A. Durante
title	Single-cell analysis reveals new evolutionary complexity in uveal melanoma
title_short	Single-cell analysis reveals new evolutionary complexity in uveal melanoma
title_full	Single-cell analysis reveals new evolutionary complexity in uveal melanoma
title_fullStr	Single-cell analysis reveals new evolutionary complexity in uveal melanoma
title_full_unstemmed	Single-cell analysis reveals new evolutionary complexity in uveal melanoma
title_sort	single-cell analysis reveals new evolutionary complexity in uveal melanoma
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/44e8def81b794cf189b9ab19348ac21d
work_keys_str_mv	AT michaeladurante singlecellanalysisrevealsnewevolutionarycomplexityinuvealmelanoma AT danielarodriguez singlecellanalysisrevealsnewevolutionarycomplexityinuvealmelanoma AT stefankurtenbach singlecellanalysisrevealsnewevolutionarycomplexityinuvealmelanoma AT jeffimnkuznetsov singlecellanalysisrevealsnewevolutionarycomplexityinuvealmelanoma AT margaretisanchez singlecellanalysisrevealsnewevolutionarycomplexityinuvealmelanoma AT christinaldecatur singlecellanalysisrevealsnewevolutionarycomplexityinuvealmelanoma AT helensnyder singlecellanalysisrevealsnewevolutionarycomplexityinuvealmelanoma AT lynngfeun singlecellanalysisrevealsnewevolutionarycomplexityinuvealmelanoma AT alanslivingstone singlecellanalysisrevealsnewevolutionarycomplexityinuvealmelanoma AT jwilliamharbour singlecellanalysisrevealsnewevolutionarycomplexityinuvealmelanoma
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Single-cell analysis reveals new evolutionary complexity in uveal melanoma

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