PKM2-dependent glycolysis promotes NLRP3 and AIM2 inflammasome activation

Inflammation involves a Warburg effect that switches cellular metabolism to glycolysis. Here the authors show this switch drives IL-1β, IL-18 and HMGB1 release from macrophages by activating the NLRP3 and AIM2 inflammasomes via protein kinase R phosphorylation, a pathway that can be inhibited to pre...

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Auteurs principaux:	Min Xie, Yan Yu, Rui Kang, Shan Zhu, Liangchun Yang, Ling Zeng, Xiaofang Sun, Minghua Yang, Timothy R. Billiar, Haichao Wang, Lizhi Cao, Jianxin Jiang, Daolin Tang
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2016
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/44e902eea61c43bbab9d4975480e57e9
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spelling	oai:doaj.org-article:44e902eea61c43bbab9d4975480e57e92021-12-02T15:34:54ZPKM2-dependent glycolysis promotes NLRP3 and AIM2 inflammasome activation10.1038/ncomms132802041-1723https://doaj.org/article/44e902eea61c43bbab9d4975480e57e92016-10-01T00:00:00Zhttps://doi.org/10.1038/ncomms13280https://doaj.org/toc/2041-1723Inflammation involves a Warburg effect that switches cellular metabolism to glycolysis. Here the authors show this switch drives IL-1β, IL-18 and HMGB1 release from macrophages by activating the NLRP3 and AIM2 inflammasomes via protein kinase R phosphorylation, a pathway that can be inhibited to prevent sepsis in mice.Min XieYan YuRui KangShan ZhuLiangchun YangLing ZengXiaofang SunMinghua YangTimothy R. BilliarHaichao WangLizhi CaoJianxin JiangDaolin TangNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Min Xie Yan Yu Rui Kang Shan Zhu Liangchun Yang Ling Zeng Xiaofang Sun Minghua Yang Timothy R. Billiar Haichao Wang Lizhi Cao Jianxin Jiang Daolin Tang PKM2-dependent glycolysis promotes NLRP3 and AIM2 inflammasome activation
description	Inflammation involves a Warburg effect that switches cellular metabolism to glycolysis. Here the authors show this switch drives IL-1β, IL-18 and HMGB1 release from macrophages by activating the NLRP3 and AIM2 inflammasomes via protein kinase R phosphorylation, a pathway that can be inhibited to prevent sepsis in mice.
format	article
author	Min Xie Yan Yu Rui Kang Shan Zhu Liangchun Yang Ling Zeng Xiaofang Sun Minghua Yang Timothy R. Billiar Haichao Wang Lizhi Cao Jianxin Jiang Daolin Tang
author_facet	Min Xie Yan Yu Rui Kang Shan Zhu Liangchun Yang Ling Zeng Xiaofang Sun Minghua Yang Timothy R. Billiar Haichao Wang Lizhi Cao Jianxin Jiang Daolin Tang
author_sort	Min Xie
title	PKM2-dependent glycolysis promotes NLRP3 and AIM2 inflammasome activation
title_short	PKM2-dependent glycolysis promotes NLRP3 and AIM2 inflammasome activation
title_full	PKM2-dependent glycolysis promotes NLRP3 and AIM2 inflammasome activation
title_fullStr	PKM2-dependent glycolysis promotes NLRP3 and AIM2 inflammasome activation
title_full_unstemmed	PKM2-dependent glycolysis promotes NLRP3 and AIM2 inflammasome activation
title_sort	pkm2-dependent glycolysis promotes nlrp3 and aim2 inflammasome activation
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/44e902eea61c43bbab9d4975480e57e9
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PKM2-dependent glycolysis promotes NLRP3 and AIM2 inflammasome activation

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