Leptin secretion and severity of glycemic disorders in women with body weight excess

Aim. To characterize leptin secretion in fasting state and upon intravenous glucose administration in patients with type 2 diabetes mel- litus (T2DM), prediabetes and obesity. Materials and methods. 59 female patients took part in this study: 12 had no signs of glycemic disorder, 18 were diagnosed...

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Autores principales:	Alexander Vasil'evich Dreval', Irina Vladimirovna Trigolosova, Inna Vladimirovna Misnikova
Formato:	article
Lenguaje:	EN RU
Publicado:	Endocrinology Research Centre 2013
Materias:	diabetes mellitus type 2 leptin intravenous glucose tolerance test insulin Nutritional diseases. Deficiency diseases RC620-627
Acceso en línea:	https://doaj.org/article/44e92de599cb486ea5d5a54f241dad60
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spelling	oai:doaj.org-article:44e92de599cb486ea5d5a54f241dad602021-11-14T09:00:18ZLeptin secretion and severity of glycemic disorders in women with body weight excess2072-03512072-037810.14341/2072-0351-3758https://doaj.org/article/44e92de599cb486ea5d5a54f241dad602013-06-01T00:00:00Zhttps://www.dia-endojournals.ru/jour/article/view/3758https://doaj.org/toc/2072-0351https://doaj.org/toc/2072-0378Aim. To characterize leptin secretion in fasting state and upon intravenous glucose administration in patients with type 2 diabetes mel- litus (T2DM), prediabetes and obesity. Materials and methods. 59 female patients took part in this study: 12 had no signs of glycemic disorder, 18 were diagnosed with prediabetes and 30 ? with newly diagnosed T2DM. Median age was 54 [48.6?60] years, median BMI ? 33.2 [29.0?37.2] kg/m2. All participants were tested for fasting leptin, fasting insulin and blood glucose levels. Prediabetic and diabetic subjects also received a bolus intravenous injection of 40% glucose solution (0.75 g/kg of body mass) with subsequent additional measurement of insulin levels at 2, 70 and 120 min upon injection, and leptin levels ? at 120 min. Results. Median fasting leptin in obese and patients with weight excess was 42.0 [22?60] ng/mL, which is about 2 times higher than normal reference maximum (27.6 ng/mL). Subjects with prediabetes and T2DM showed significantly lower median fasting leptin levels of 29.1 ng/mL [13.5?45.7] and 21.3 [14.3?42.2], respectively (pAlexander Vasil'evich Dreval'Irina Vladimirovna TrigolosovaInna Vladimirovna MisnikovaEndocrinology Research Centrearticlediabetes mellitus type 2leptinintravenous glucose tolerance testinsulinNutritional diseases. Deficiency diseasesRC620-627ENRUСахарный диабет, Vol 16, Iss 2, Pp 67-72 (2013)
institution	DOAJ
collection	DOAJ
language	EN RU
topic	diabetes mellitus type 2 leptin intravenous glucose tolerance test insulin Nutritional diseases. Deficiency diseases RC620-627
spellingShingle	diabetes mellitus type 2 leptin intravenous glucose tolerance test insulin Nutritional diseases. Deficiency diseases RC620-627 Alexander Vasil'evich Dreval' Irina Vladimirovna Trigolosova Inna Vladimirovna Misnikova Leptin secretion and severity of glycemic disorders in women with body weight excess
description	Aim. To characterize leptin secretion in fasting state and upon intravenous glucose administration in patients with type 2 diabetes mel- litus (T2DM), prediabetes and obesity. Materials and methods. 59 female patients took part in this study: 12 had no signs of glycemic disorder, 18 were diagnosed with prediabetes and 30 ? with newly diagnosed T2DM. Median age was 54 [48.6?60] years, median BMI ? 33.2 [29.0?37.2] kg/m2. All participants were tested for fasting leptin, fasting insulin and blood glucose levels. Prediabetic and diabetic subjects also received a bolus intravenous injection of 40% glucose solution (0.75 g/kg of body mass) with subsequent additional measurement of insulin levels at 2, 70 and 120 min upon injection, and leptin levels ? at 120 min. Results. Median fasting leptin in obese and patients with weight excess was 42.0 [22?60] ng/mL, which is about 2 times higher than normal reference maximum (27.6 ng/mL). Subjects with prediabetes and T2DM showed significantly lower median fasting leptin levels of 29.1 ng/mL [13.5?45.7] and 21.3 [14.3?42.2], respectively (p
format	article
author	Alexander Vasil'evich Dreval' Irina Vladimirovna Trigolosova Inna Vladimirovna Misnikova
author_facet	Alexander Vasil'evich Dreval' Irina Vladimirovna Trigolosova Inna Vladimirovna Misnikova
author_sort	Alexander Vasil'evich Dreval'
title	Leptin secretion and severity of glycemic disorders in women with body weight excess
title_short	Leptin secretion and severity of glycemic disorders in women with body weight excess
title_full	Leptin secretion and severity of glycemic disorders in women with body weight excess
title_fullStr	Leptin secretion and severity of glycemic disorders in women with body weight excess
title_full_unstemmed	Leptin secretion and severity of glycemic disorders in women with body weight excess
title_sort	leptin secretion and severity of glycemic disorders in women with body weight excess
publisher	Endocrinology Research Centre
publishDate	2013
url	https://doaj.org/article/44e92de599cb486ea5d5a54f241dad60
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Leptin secretion and severity of glycemic disorders in women with body weight excess

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