Biochemical reconstitution of TET1–TDG–BER-dependent active DNA demethylation reveals a highly coordinated mechanism

Cytosine methylation is a dynamic DNA modification with the involvement of the base excision repair pathway suspected to be involved in demethylation. Here the authors show that TET1 and TDG interact to target modified bases and coordinate BER to avoid double strand breaks.

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Autores principales:	Alain R. Weber, Claudia Krawczyk, Adam B. Robertson, Anna Kuśnierczyk, Cathrine B. Vågbø, David Schuermann, Arne Klungland, Primo Schär
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/44eb7c1d95384a8bb025afc098bf1cf5
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spelling	oai:doaj.org-article:44eb7c1d95384a8bb025afc098bf1cf52021-12-02T14:40:13ZBiochemical reconstitution of TET1–TDG–BER-dependent active DNA demethylation reveals a highly coordinated mechanism10.1038/ncomms108062041-1723https://doaj.org/article/44eb7c1d95384a8bb025afc098bf1cf52016-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms10806https://doaj.org/toc/2041-1723Cytosine methylation is a dynamic DNA modification with the involvement of the base excision repair pathway suspected to be involved in demethylation. Here the authors show that TET1 and TDG interact to target modified bases and coordinate BER to avoid double strand breaks.Alain R. WeberClaudia KrawczykAdam B. RobertsonAnna KuśnierczykCathrine B. VågbøDavid SchuermannArne KlunglandPrimo SchärNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Alain R. Weber Claudia Krawczyk Adam B. Robertson Anna Kuśnierczyk Cathrine B. Vågbø David Schuermann Arne Klungland Primo Schär Biochemical reconstitution of TET1–TDG–BER-dependent active DNA demethylation reveals a highly coordinated mechanism
description	Cytosine methylation is a dynamic DNA modification with the involvement of the base excision repair pathway suspected to be involved in demethylation. Here the authors show that TET1 and TDG interact to target modified bases and coordinate BER to avoid double strand breaks.
format	article
author	Alain R. Weber Claudia Krawczyk Adam B. Robertson Anna Kuśnierczyk Cathrine B. Vågbø David Schuermann Arne Klungland Primo Schär
author_facet	Alain R. Weber Claudia Krawczyk Adam B. Robertson Anna Kuśnierczyk Cathrine B. Vågbø David Schuermann Arne Klungland Primo Schär
author_sort	Alain R. Weber
title	Biochemical reconstitution of TET1–TDG–BER-dependent active DNA demethylation reveals a highly coordinated mechanism
title_short	Biochemical reconstitution of TET1–TDG–BER-dependent active DNA demethylation reveals a highly coordinated mechanism
title_full	Biochemical reconstitution of TET1–TDG–BER-dependent active DNA demethylation reveals a highly coordinated mechanism
title_fullStr	Biochemical reconstitution of TET1–TDG–BER-dependent active DNA demethylation reveals a highly coordinated mechanism
title_full_unstemmed	Biochemical reconstitution of TET1–TDG–BER-dependent active DNA demethylation reveals a highly coordinated mechanism
title_sort	biochemical reconstitution of tet1–tdg–ber-dependent active dna demethylation reveals a highly coordinated mechanism
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/44eb7c1d95384a8bb025afc098bf1cf5
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Biochemical reconstitution of TET1–TDG–BER-dependent active DNA demethylation reveals a highly coordinated mechanism

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