Do eyes with and without optic neuritis in multiple sclerosis age equally?

Jana Lizrova Preiningerova,1 Anna Grishko,2 Lukas Sobisek,2 Michaela Andelova,1 Barbora Benova,1 Karolina Kucerova,1 Eva Kubala Havrdova1 1Center of Clinical Neuroscience, Department of Neurology, General University Hospital, 1st Faculty of Medicine, Charles University, Prague Czech Republic; 2Depa...

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Autores principales:	Lizrova Preiningerova J, Grishko A, Sobisek L, Andelova M, Benova B, Kucerova K, Havrdova EK
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	optical coherence tomography neurodegeneration multiple sclerosis retina Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/44f04353ed774a96b99e78ce22c5feec
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spelling	oai:doaj.org-article:44f04353ed774a96b99e78ce22c5feec2021-12-02T03:49:26ZDo eyes with and without optic neuritis in multiple sclerosis age equally?1178-2021https://doaj.org/article/44f04353ed774a96b99e78ce22c5feec2018-09-01T00:00:00Zhttps://www.dovepress.com/do-eyes-with-and-without-optic-neuritis-in-multiple-sclerosis-age-equa-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Jana Lizrova Preiningerova,1 Anna Grishko,2 Lukas Sobisek,2 Michaela Andelova,1 Barbora Benova,1 Karolina Kucerova,1 Eva Kubala Havrdova1 1Center of Clinical Neuroscience, Department of Neurology, General University Hospital, 1st Faculty of Medicine, Charles University, Prague Czech Republic; 2Department of Statistics and Probability, University of Economics, Prague, Czech Republic Purpose: Anterior visual pathway reflects axonal loss caused by both optic neuritis (ON) and neurodegeneration in multiple sclerosis (MS). Although the axonal injury post-ON is thought to be complete by 6 months of onset, most studies using optical coherence tomography (OCT) to evaluate retinal changes as a marker of neurodegeneration exclude eyes with a history of ON or consider them separately. The objective of this study was to assess whether the eyes post-ON (>6 months) show in later years different rate of chronic retinal changes than the fellow eyes not affected by ON. Patients and methods: Fifty-six patients with MS with a history of ON in one eye (ON eyes) and no ON in the fellow (FL) eye, who were followed by OCT for >2 years, were selected from a cohort of patients with MS. Paired eye analysis was performed. Results: Mean interval post-ON at baseline was 5.65 (SD 5.05) years. Mean length of follow-up by OCT was 4.57 years. There was no statistical difference in absolute or relative thinning of retinal nerve fiber layer in peripapillary area between the ON and FL eyes. Conclusion: This study has shown that we do not need to exclude eyes with a history of ON from longitudinal studies of neurodegeneration in MS, provided that we use data outside of the frame of acute changes post-ON. Long-term changes of peripapillary retinal nerve fiber layer in ON and FL eyes are equal. Keywords: optical coherence tomography, neurodegeneration, multiple sclerosis, retinaLizrova Preiningerova JGrishko ASobisek LAndelova MBenova BKucerova KHavrdova EKDove Medical Pressarticleoptical coherence tomographyneurodegenerationmultiple sclerosisretinaNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 14, Pp 2281-2285 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	optical coherence tomography neurodegeneration multiple sclerosis retina Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	optical coherence tomography neurodegeneration multiple sclerosis retina Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Lizrova Preiningerova J Grishko A Sobisek L Andelova M Benova B Kucerova K Havrdova EK Do eyes with and without optic neuritis in multiple sclerosis age equally?
description	Jana Lizrova Preiningerova,1 Anna Grishko,2 Lukas Sobisek,2 Michaela Andelova,1 Barbora Benova,1 Karolina Kucerova,1 Eva Kubala Havrdova1 1Center of Clinical Neuroscience, Department of Neurology, General University Hospital, 1st Faculty of Medicine, Charles University, Prague Czech Republic; 2Department of Statistics and Probability, University of Economics, Prague, Czech Republic Purpose: Anterior visual pathway reflects axonal loss caused by both optic neuritis (ON) and neurodegeneration in multiple sclerosis (MS). Although the axonal injury post-ON is thought to be complete by 6 months of onset, most studies using optical coherence tomography (OCT) to evaluate retinal changes as a marker of neurodegeneration exclude eyes with a history of ON or consider them separately. The objective of this study was to assess whether the eyes post-ON (>6 months) show in later years different rate of chronic retinal changes than the fellow eyes not affected by ON. Patients and methods: Fifty-six patients with MS with a history of ON in one eye (ON eyes) and no ON in the fellow (FL) eye, who were followed by OCT for >2 years, were selected from a cohort of patients with MS. Paired eye analysis was performed. Results: Mean interval post-ON at baseline was 5.65 (SD 5.05) years. Mean length of follow-up by OCT was 4.57 years. There was no statistical difference in absolute or relative thinning of retinal nerve fiber layer in peripapillary area between the ON and FL eyes. Conclusion: This study has shown that we do not need to exclude eyes with a history of ON from longitudinal studies of neurodegeneration in MS, provided that we use data outside of the frame of acute changes post-ON. Long-term changes of peripapillary retinal nerve fiber layer in ON and FL eyes are equal. Keywords: optical coherence tomography, neurodegeneration, multiple sclerosis, retina
format	article
author	Lizrova Preiningerova J Grishko A Sobisek L Andelova M Benova B Kucerova K Havrdova EK
author_facet	Lizrova Preiningerova J Grishko A Sobisek L Andelova M Benova B Kucerova K Havrdova EK
author_sort	Lizrova Preiningerova J
title	Do eyes with and without optic neuritis in multiple sclerosis age equally?
title_short	Do eyes with and without optic neuritis in multiple sclerosis age equally?
title_full	Do eyes with and without optic neuritis in multiple sclerosis age equally?
title_fullStr	Do eyes with and without optic neuritis in multiple sclerosis age equally?
title_full_unstemmed	Do eyes with and without optic neuritis in multiple sclerosis age equally?
title_sort	do eyes with and without optic neuritis in multiple sclerosis age equally?
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/44f04353ed774a96b99e78ce22c5feec
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_version_	1718401597986308096

Do eyes with and without optic neuritis in multiple sclerosis age equally?

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