Ultra-sensitive and rapid detection of nucleic acids and microorganisms in body fluids using single-molecule tethering

Culture-based diagnostic methods for microorganism detection are time-consuming but still the gold standard for conditions such as sepsis. Here the authors present an amplification and purification-free method to detect microorganisms in bodily fluids with high sensitivity: Single MOLecule Tethering...

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Autores principales:	Wen-Chih Cheng, Troy Horn, Maya Zayats, Georges Rizk, Samuel Major, Hongying Zhu, Joseph Russell, Zhiguang Xu, Richard E. Rothman, Alfredo Celedon
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/44f130550ba44ae8a92f53c241c2313e
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spelling	oai:doaj.org-article:44f130550ba44ae8a92f53c241c2313e2021-12-02T18:13:46ZUltra-sensitive and rapid detection of nucleic acids and microorganisms in body fluids using single-molecule tethering10.1038/s41467-020-18574-72041-1723https://doaj.org/article/44f130550ba44ae8a92f53c241c2313e2020-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18574-7https://doaj.org/toc/2041-1723Culture-based diagnostic methods for microorganism detection are time-consuming but still the gold standard for conditions such as sepsis. Here the authors present an amplification and purification-free method to detect microorganisms in bodily fluids with high sensitivity: Single MOLecule Tethering (SMOLT).Wen-Chih ChengTroy HornMaya ZayatsGeorges RizkSamuel MajorHongying ZhuJoseph RussellZhiguang XuRichard E. RothmanAlfredo CeledonNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Wen-Chih Cheng Troy Horn Maya Zayats Georges Rizk Samuel Major Hongying Zhu Joseph Russell Zhiguang Xu Richard E. Rothman Alfredo Celedon Ultra-sensitive and rapid detection of nucleic acids and microorganisms in body fluids using single-molecule tethering
description	Culture-based diagnostic methods for microorganism detection are time-consuming but still the gold standard for conditions such as sepsis. Here the authors present an amplification and purification-free method to detect microorganisms in bodily fluids with high sensitivity: Single MOLecule Tethering (SMOLT).
format	article
author	Wen-Chih Cheng Troy Horn Maya Zayats Georges Rizk Samuel Major Hongying Zhu Joseph Russell Zhiguang Xu Richard E. Rothman Alfredo Celedon
author_facet	Wen-Chih Cheng Troy Horn Maya Zayats Georges Rizk Samuel Major Hongying Zhu Joseph Russell Zhiguang Xu Richard E. Rothman Alfredo Celedon
author_sort	Wen-Chih Cheng
title	Ultra-sensitive and rapid detection of nucleic acids and microorganisms in body fluids using single-molecule tethering
title_short	Ultra-sensitive and rapid detection of nucleic acids and microorganisms in body fluids using single-molecule tethering
title_full	Ultra-sensitive and rapid detection of nucleic acids and microorganisms in body fluids using single-molecule tethering
title_fullStr	Ultra-sensitive and rapid detection of nucleic acids and microorganisms in body fluids using single-molecule tethering
title_full_unstemmed	Ultra-sensitive and rapid detection of nucleic acids and microorganisms in body fluids using single-molecule tethering
title_sort	ultra-sensitive and rapid detection of nucleic acids and microorganisms in body fluids using single-molecule tethering
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/44f130550ba44ae8a92f53c241c2313e
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Ultra-sensitive and rapid detection of nucleic acids and microorganisms in body fluids using single-molecule tethering

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