TRAP1 Shows Clinical Significance in the Early Diagnosis of Small Cell Lung Cancer

Xiaohang Li,1 Xu Li,1 Simei Chen,1 Yang Wu,1 Yuhan Liu,1 Tingting Hu,1 Jiayi Huang,1 Jianlin Yu,1 Zihuan Pei,1 Tingting Zeng,2 Liming Tan1 1Department of Clinical Laboratory, The Second Affiliated Hospital of Nanchang University, Jiangxi Province Key Laboratory of Laboratory Medicine, Nanchang, Jian...

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Autores principales:	Li X, Chen S, Wu Y, Liu Y, Hu T, Huang J, Yu J, Pei Z, Zeng T, Tan L
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	trap1，diagnosis，small cell lung cancer clinical stage metastasis Pathology RB1-214 Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/44f25e88c72e4deab7a46507c83f8338
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spelling	oai:doaj.org-article:44f25e88c72e4deab7a46507c83f83382021-12-02T17:40:59ZTRAP1 Shows Clinical Significance in the Early Diagnosis of Small Cell Lung Cancer1178-7031https://doaj.org/article/44f25e88c72e4deab7a46507c83f83382021-06-01T00:00:00Zhttps://www.dovepress.com/trap1-shows-clinical-significance-in-the-early-diagnosis-of-small-cell-peer-reviewed-fulltext-article-JIRhttps://doaj.org/toc/1178-7031Xiaohang Li,1 Xu Li,1 Simei Chen,1 Yang Wu,1 Yuhan Liu,1 Tingting Hu,1 Jiayi Huang,1 Jianlin Yu,1 Zihuan Pei,1 Tingting Zeng,2 Liming Tan1 1Department of Clinical Laboratory, The Second Affiliated Hospital of Nanchang University, Jiangxi Province Key Laboratory of Laboratory Medicine, Nanchang, Jiangxi, People’s Republic of China; 2Department of Clinical Laboratory, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, People’s Republic of ChinaCorrespondence: Liming TanDepartment of Clinical Laboratory, The Second Affiliated Hospital of Nanchang University, Jiangxi Province Key Laboratory of Laboratory Medicine, No. 1 Minde Road, Donghu District, Nanchang, Jiangxi, People’s Republic of ChinaTel +86 791-86300410Email ndefy84029@ncu.edu.cnPurpose: To explore the clinical significance of tumor necrosis factor receptor-associated protein (TRAP1), mitotic arrest deficient 2 (mad2) and anti-nuclear mitotic spindle apparatus antibody (MSA) in the diagnosis of small cell lung cancer (SCLC).Patients and Methods: Serum concentrations of TRAP1 and MSA were determined by enzyme-linked immunosorbent assay (ELISA), including SCLC group (Num.=86), non-small cell lung cancer (NSCLC) group (Num.=105), pulmonary nodules (PN) group (Num.=94), and 60 healthy subjects as control group (Num.=60). Whereas fluorescence quantitative PCR (qt-PCR) method was used to detect the expression of mad2.Results: The expression of TRAP1 was low in SCLC and NSCLC compared with the other two groups, and was the lowest in SCLC, which was negatively correlated with the occurrence of the disease (P< 0.05); the sensitivity and specificity of TRAP1 for SCLC were 75.29%, 93.33%, and the area under SCLC curve was 0.903; compared with the other three groups, the level of MSA was the highest in the SCLC, and the results were significantly different (P< 0.05), while the area under the SCLC curve was 0.856, and the sensitivity and specificity were 62.78% and 95.24%, respectively. Mad2 is overexpressed in SCLC, but not in PN. The area under the SCLC curve is 0.835, and the sensitivity and specificity are 56.98% and 92.38%; TRAP1 levels are negatively correlated with SCLC tumor stage, the level of TRAP1 was significantly lower in stage III–IV than in stage I–II (P< 0.05); combined analysis of TRAP1 and MAD2 and MSA showed that the sensitivity and specificity for SCLS were 95.35% and 99.05%, respectively.Conclusion: TRAP1 is of great value in the early diagnosis of SCLC as well as differential diagnosis with NSCLC. TRAP1 combined with MAD2 and MSA improved the sensitivity and specificity and provided a new idea for the clinical diagnosis of SCLC.Keywords: TRAP1, diagnosis, small cell lung cancer, clinical stage, metastasisLi XLi XChen SWu YLiu YHu THuang JYu JPei ZZeng TTan LDove Medical Pressarticletrap1，diagnosis，small cell lung cancerclinical stagemetastasisPathologyRB1-214Therapeutics. PharmacologyRM1-950ENJournal of Inflammation Research, Vol Volume 14, Pp 2507-2514 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	trap1，diagnosis，small cell lung cancer clinical stage metastasis Pathology RB1-214 Therapeutics. Pharmacology RM1-950
spellingShingle	trap1，diagnosis，small cell lung cancer clinical stage metastasis Pathology RB1-214 Therapeutics. Pharmacology RM1-950 Li X Li X Chen S Wu Y Liu Y Hu T Huang J Yu J Pei Z Zeng T Tan L TRAP1 Shows Clinical Significance in the Early Diagnosis of Small Cell Lung Cancer
description	Xiaohang Li,1 Xu Li,1 Simei Chen,1 Yang Wu,1 Yuhan Liu,1 Tingting Hu,1 Jiayi Huang,1 Jianlin Yu,1 Zihuan Pei,1 Tingting Zeng,2 Liming Tan1 1Department of Clinical Laboratory, The Second Affiliated Hospital of Nanchang University, Jiangxi Province Key Laboratory of Laboratory Medicine, Nanchang, Jiangxi, People’s Republic of China; 2Department of Clinical Laboratory, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, People’s Republic of ChinaCorrespondence: Liming TanDepartment of Clinical Laboratory, The Second Affiliated Hospital of Nanchang University, Jiangxi Province Key Laboratory of Laboratory Medicine, No. 1 Minde Road, Donghu District, Nanchang, Jiangxi, People’s Republic of ChinaTel +86 791-86300410Email ndefy84029@ncu.edu.cnPurpose: To explore the clinical significance of tumor necrosis factor receptor-associated protein (TRAP1), mitotic arrest deficient 2 (mad2) and anti-nuclear mitotic spindle apparatus antibody (MSA) in the diagnosis of small cell lung cancer (SCLC).Patients and Methods: Serum concentrations of TRAP1 and MSA were determined by enzyme-linked immunosorbent assay (ELISA), including SCLC group (Num.=86), non-small cell lung cancer (NSCLC) group (Num.=105), pulmonary nodules (PN) group (Num.=94), and 60 healthy subjects as control group (Num.=60). Whereas fluorescence quantitative PCR (qt-PCR) method was used to detect the expression of mad2.Results: The expression of TRAP1 was low in SCLC and NSCLC compared with the other two groups, and was the lowest in SCLC, which was negatively correlated with the occurrence of the disease (P< 0.05); the sensitivity and specificity of TRAP1 for SCLC were 75.29%, 93.33%, and the area under SCLC curve was 0.903; compared with the other three groups, the level of MSA was the highest in the SCLC, and the results were significantly different (P< 0.05), while the area under the SCLC curve was 0.856, and the sensitivity and specificity were 62.78% and 95.24%, respectively. Mad2 is overexpressed in SCLC, but not in PN. The area under the SCLC curve is 0.835, and the sensitivity and specificity are 56.98% and 92.38%; TRAP1 levels are negatively correlated with SCLC tumor stage, the level of TRAP1 was significantly lower in stage III–IV than in stage I–II (P< 0.05); combined analysis of TRAP1 and MAD2 and MSA showed that the sensitivity and specificity for SCLS were 95.35% and 99.05%, respectively.Conclusion: TRAP1 is of great value in the early diagnosis of SCLC as well as differential diagnosis with NSCLC. TRAP1 combined with MAD2 and MSA improved the sensitivity and specificity and provided a new idea for the clinical diagnosis of SCLC.Keywords: TRAP1, diagnosis, small cell lung cancer, clinical stage, metastasis
format	article
author	Li X Li X Chen S Wu Y Liu Y Hu T Huang J Yu J Pei Z Zeng T Tan L
author_facet	Li X Li X Chen S Wu Y Liu Y Hu T Huang J Yu J Pei Z Zeng T Tan L
author_sort	Li X
title	TRAP1 Shows Clinical Significance in the Early Diagnosis of Small Cell Lung Cancer
title_short	TRAP1 Shows Clinical Significance in the Early Diagnosis of Small Cell Lung Cancer
title_full	TRAP1 Shows Clinical Significance in the Early Diagnosis of Small Cell Lung Cancer
title_fullStr	TRAP1 Shows Clinical Significance in the Early Diagnosis of Small Cell Lung Cancer
title_full_unstemmed	TRAP1 Shows Clinical Significance in the Early Diagnosis of Small Cell Lung Cancer
title_sort	trap1 shows clinical significance in the early diagnosis of small cell lung cancer
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/44f25e88c72e4deab7a46507c83f8338
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TRAP1 Shows Clinical Significance in the Early Diagnosis of Small Cell Lung Cancer

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