Central Injection of Ghrelin Improves Motor Balance in the Rotarod Test in the Rats: Altering the Expression of Drd1 Gene

Introduction: Motor learning consolidates in adulthood, and its defects begin to appear with aging. Ghrelin, an endogenous peptide, improves memory and learning, targeting dopaminergic circuits. While cytidine diphosphate choline (citicoline) is known as a common drug for enhancing memory and learni...

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Autores principales:	Vahideh Sahraiian, Homayoun Khazali
Formato:	article
Lenguaje:	EN
Publicado:	Zabol University of Medical sciences 2021
Materias:	ghrelin cytidine diphosphate choline rotarod performance test real-time polymerase chain reaction Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/44f5553558e94aea80e4c6d9e518e92b
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spelling	oai:doaj.org-article:44f5553558e94aea80e4c6d9e518e92b2021-11-17T09:55:03ZCentral Injection of Ghrelin Improves Motor Balance in the Rotarod Test in the Rats: Altering the Expression of Drd1 Gene2476-664X10.34172/ijbsm.2021.02https://doaj.org/article/44f5553558e94aea80e4c6d9e518e92b2021-03-01T00:00:00Zhttp://ijbsm.zbmu.ac.ir/PDF/ijbsm-21464https://doaj.org/toc/2476-664XIntroduction: Motor learning consolidates in adulthood, and its defects begin to appear with aging. Ghrelin, an endogenous peptide, improves memory and learning, targeting dopaminergic circuits. While cytidine diphosphate choline (citicoline) is known as a common drug for enhancing memory and learning in aging, it is not recommended for adults due to its side effects. The current study aimed at investigating if ghrelin treatment would improve motor learning via the expression of a relevant gene. Methods: For this experimental study, adult male Wistar rats were randomly divided into five groups: control group, three groups of ghrelin treatment (0.3, 1.5, and 3 nmol/μL), and one group with citicoline treatment. The injections were done intra-hippocampally. The motor learning rate was determined using the rotarod performance test by measuring the resistance to falling. Then the expression of dopamine receptor type D1 (Drd1) gene in the hippocampus was measured by a real-time polymerase chain reaction (PCR). Results: Ghrelin (3 nmol/μL) and citicoline had similar and significant effects on motor learning improvement (P<0.01). Both drugs significantly increased Drd1 gene expression (P <0.001). Conclusion: Ghrelin, like citicoline, improves motor learning by altering the expression of Drd1 gene in the hippocampus.Vahideh SahraiianHomayoun KhazaliZabol University of Medical sciencesarticleghrelin cytidine diphosphate choline rotarod performance test real-time polymerase chain reaction Medicine (General)R5-920ENInternational Journal of Basic Science in Medicine, Vol 6, Iss 1, Pp 11-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	ghrelin cytidine diphosphate choline rotarod performance test real-time polymerase chain reaction Medicine (General) R5-920
spellingShingle	ghrelin cytidine diphosphate choline rotarod performance test real-time polymerase chain reaction Medicine (General) R5-920 Vahideh Sahraiian Homayoun Khazali Central Injection of Ghrelin Improves Motor Balance in the Rotarod Test in the Rats: Altering the Expression of Drd1 Gene
description	Introduction: Motor learning consolidates in adulthood, and its defects begin to appear with aging. Ghrelin, an endogenous peptide, improves memory and learning, targeting dopaminergic circuits. While cytidine diphosphate choline (citicoline) is known as a common drug for enhancing memory and learning in aging, it is not recommended for adults due to its side effects. The current study aimed at investigating if ghrelin treatment would improve motor learning via the expression of a relevant gene. Methods: For this experimental study, adult male Wistar rats were randomly divided into five groups: control group, three groups of ghrelin treatment (0.3, 1.5, and 3 nmol/μL), and one group with citicoline treatment. The injections were done intra-hippocampally. The motor learning rate was determined using the rotarod performance test by measuring the resistance to falling. Then the expression of dopamine receptor type D1 (Drd1) gene in the hippocampus was measured by a real-time polymerase chain reaction (PCR). Results: Ghrelin (3 nmol/μL) and citicoline had similar and significant effects on motor learning improvement (P<0.01). Both drugs significantly increased Drd1 gene expression (P <0.001). Conclusion: Ghrelin, like citicoline, improves motor learning by altering the expression of Drd1 gene in the hippocampus.
format	article
author	Vahideh Sahraiian Homayoun Khazali
author_facet	Vahideh Sahraiian Homayoun Khazali
author_sort	Vahideh Sahraiian
title	Central Injection of Ghrelin Improves Motor Balance in the Rotarod Test in the Rats: Altering the Expression of Drd1 Gene
title_short	Central Injection of Ghrelin Improves Motor Balance in the Rotarod Test in the Rats: Altering the Expression of Drd1 Gene
title_full	Central Injection of Ghrelin Improves Motor Balance in the Rotarod Test in the Rats: Altering the Expression of Drd1 Gene
title_fullStr	Central Injection of Ghrelin Improves Motor Balance in the Rotarod Test in the Rats: Altering the Expression of Drd1 Gene
title_full_unstemmed	Central Injection of Ghrelin Improves Motor Balance in the Rotarod Test in the Rats: Altering the Expression of Drd1 Gene
title_sort	central injection of ghrelin improves motor balance in the rotarod test in the rats: altering the expression of drd1 gene
publisher	Zabol University of Medical sciences
publishDate	2021
url	https://doaj.org/article/44f5553558e94aea80e4c6d9e518e92b
work_keys_str_mv	AT vahidehsahraiian centralinjectionofghrelinimprovesmotorbalanceintherotarodtestintheratsalteringtheexpressionofdrd1gene AT homayounkhazali centralinjectionofghrelinimprovesmotorbalanceintherotarodtestintheratsalteringtheexpressionofdrd1gene
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Central Injection of Ghrelin Improves Motor Balance in the Rotarod Test in the Rats: Altering the Expression of Drd1 Gene

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