TRIM28 SUMOylates and stabilizes NLRP3 to facilitate inflammasome activation

Post-translational modifications are important regulators of NLRP3 inflammasome activity. Here the authors show that the E3 ligase TRIM28 can SUMOylate NLRP3, thereby limiting its proteasomal degradation and increasing NLRP3 inflammasome activity.

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Autores principales:	Ying Qin, Qi Li, Wenbo Liang, Rongzhen Yan, Li Tong, Mutian Jia, Chunyuan Zhao, Wei Zhao
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/44f90e47855d43ca9739936ce57bb459
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spelling	oai:doaj.org-article:44f90e47855d43ca9739936ce57bb4592021-12-02T18:50:44ZTRIM28 SUMOylates and stabilizes NLRP3 to facilitate inflammasome activation10.1038/s41467-021-25033-42041-1723https://doaj.org/article/44f90e47855d43ca9739936ce57bb4592021-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25033-4https://doaj.org/toc/2041-1723Post-translational modifications are important regulators of NLRP3 inflammasome activity. Here the authors show that the E3 ligase TRIM28 can SUMOylate NLRP3, thereby limiting its proteasomal degradation and increasing NLRP3 inflammasome activity.Ying QinQi LiWenbo LiangRongzhen YanLi TongMutian JiaChunyuan ZhaoWei ZhaoNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ying Qin Qi Li Wenbo Liang Rongzhen Yan Li Tong Mutian Jia Chunyuan Zhao Wei Zhao TRIM28 SUMOylates and stabilizes NLRP3 to facilitate inflammasome activation
description	Post-translational modifications are important regulators of NLRP3 inflammasome activity. Here the authors show that the E3 ligase TRIM28 can SUMOylate NLRP3, thereby limiting its proteasomal degradation and increasing NLRP3 inflammasome activity.
format	article
author	Ying Qin Qi Li Wenbo Liang Rongzhen Yan Li Tong Mutian Jia Chunyuan Zhao Wei Zhao
author_facet	Ying Qin Qi Li Wenbo Liang Rongzhen Yan Li Tong Mutian Jia Chunyuan Zhao Wei Zhao
author_sort	Ying Qin
title	TRIM28 SUMOylates and stabilizes NLRP3 to facilitate inflammasome activation
title_short	TRIM28 SUMOylates and stabilizes NLRP3 to facilitate inflammasome activation
title_full	TRIM28 SUMOylates and stabilizes NLRP3 to facilitate inflammasome activation
title_fullStr	TRIM28 SUMOylates and stabilizes NLRP3 to facilitate inflammasome activation
title_full_unstemmed	TRIM28 SUMOylates and stabilizes NLRP3 to facilitate inflammasome activation
title_sort	trim28 sumoylates and stabilizes nlrp3 to facilitate inflammasome activation
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/44f90e47855d43ca9739936ce57bb459
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TRIM28 SUMOylates and stabilizes NLRP3 to facilitate inflammasome activation

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