TRIM28 SUMOylates and stabilizes NLRP3 to facilitate inflammasome activation

TRIM28 SUMOylates and stabilizes NLRP3 to facilitate inflammasome activation

Post-translational modifications are important regulators of NLRP3 inflammasome activity. Here the authors show that the E3 ligase TRIM28 can SUMOylate NLRP3, thereby limiting its proteasomal degradation and increasing NLRP3 inflammasome activity.

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Autores principales: Ying Qin, Qi Li, Wenbo Liang, Rongzhen Yan, Li Tong, Mutian Jia, Chunyuan Zhao, Wei Zhao
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/44f90e47855d43ca9739936ce57bb459
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