Exposure to melamine cyanuric acid in adult mice induced thyroid dysfunction and circadian rhythm disorder

MCA is a halogen-free flame retardant. It can cause damage to other tissues such as the kidneys and liver. However, the effects on the circadian rhythm and thyroid in adult mice have not been studied. In this article, adult male mice received MCA at concentrations of 0, 10, 20, 30 mg/kg. The results...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Sijie Wang, Songdi Wang, Chenxi Wang, Daofu Feng, Xizeng Feng
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Melamine cyanuric acid Thyroid Circadian rhythm UCP1 Environmental pollution TD172-193.5 Environmental sciences GE1-350
Acceso en línea:	https://doaj.org/article/44f9c4c96cb4456ea1550f9011a93257
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:44f9c4c96cb4456ea1550f9011a93257
record_format	dspace
spelling	oai:doaj.org-article:44f9c4c96cb4456ea1550f9011a932572021-11-22T04:16:35ZExposure to melamine cyanuric acid in adult mice induced thyroid dysfunction and circadian rhythm disorder0147-651310.1016/j.ecoenv.2021.112992https://doaj.org/article/44f9c4c96cb4456ea1550f9011a932572021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S0147651321011040https://doaj.org/toc/0147-6513MCA is a halogen-free flame retardant. It can cause damage to other tissues such as the kidneys and liver. However, the effects on the circadian rhythm and thyroid in adult mice have not been studied. In this article, adult male mice received MCA at concentrations of 0, 10, 20, 30 mg/kg. The results showed that the time spending on wheel-running and rest bouts changed in different period after MCA exposure. MCA disrupted the T3 and T4 hormone homeostasis and decreased the expression of thyroid hormone synthesis genes. The histological morphology of the thyroid gland was damaged. It was suggested that MCA exposure caused circadian rhythm disorder and thyroid dysfunction.Sijie WangSongdi WangChenxi WangDaofu FengXizeng FengElsevierarticleMelamine cyanuric acidThyroidCircadian rhythmUCP1Environmental pollutionTD172-193.5Environmental sciencesGE1-350ENEcotoxicology and Environmental Safety, Vol 228, Iss , Pp 112992- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Melamine cyanuric acid Thyroid Circadian rhythm UCP1 Environmental pollution TD172-193.5 Environmental sciences GE1-350
spellingShingle	Melamine cyanuric acid Thyroid Circadian rhythm UCP1 Environmental pollution TD172-193.5 Environmental sciences GE1-350 Sijie Wang Songdi Wang Chenxi Wang Daofu Feng Xizeng Feng Exposure to melamine cyanuric acid in adult mice induced thyroid dysfunction and circadian rhythm disorder
description	MCA is a halogen-free flame retardant. It can cause damage to other tissues such as the kidneys and liver. However, the effects on the circadian rhythm and thyroid in adult mice have not been studied. In this article, adult male mice received MCA at concentrations of 0, 10, 20, 30 mg/kg. The results showed that the time spending on wheel-running and rest bouts changed in different period after MCA exposure. MCA disrupted the T3 and T4 hormone homeostasis and decreased the expression of thyroid hormone synthesis genes. The histological morphology of the thyroid gland was damaged. It was suggested that MCA exposure caused circadian rhythm disorder and thyroid dysfunction.
format	article
author	Sijie Wang Songdi Wang Chenxi Wang Daofu Feng Xizeng Feng
author_facet	Sijie Wang Songdi Wang Chenxi Wang Daofu Feng Xizeng Feng
author_sort	Sijie Wang
title	Exposure to melamine cyanuric acid in adult mice induced thyroid dysfunction and circadian rhythm disorder
title_short	Exposure to melamine cyanuric acid in adult mice induced thyroid dysfunction and circadian rhythm disorder
title_full	Exposure to melamine cyanuric acid in adult mice induced thyroid dysfunction and circadian rhythm disorder
title_fullStr	Exposure to melamine cyanuric acid in adult mice induced thyroid dysfunction and circadian rhythm disorder
title_full_unstemmed	Exposure to melamine cyanuric acid in adult mice induced thyroid dysfunction and circadian rhythm disorder
title_sort	exposure to melamine cyanuric acid in adult mice induced thyroid dysfunction and circadian rhythm disorder
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/44f9c4c96cb4456ea1550f9011a93257
work_keys_str_mv	AT sijiewang exposuretomelaminecyanuricacidinadultmiceinducedthyroiddysfunctionandcircadianrhythmdisorder AT songdiwang exposuretomelaminecyanuricacidinadultmiceinducedthyroiddysfunctionandcircadianrhythmdisorder AT chenxiwang exposuretomelaminecyanuricacidinadultmiceinducedthyroiddysfunctionandcircadianrhythmdisorder AT daofufeng exposuretomelaminecyanuricacidinadultmiceinducedthyroiddysfunctionandcircadianrhythmdisorder AT xizengfeng exposuretomelaminecyanuricacidinadultmiceinducedthyroiddysfunctionandcircadianrhythmdisorder
_version_	1718418218171760640

Exposure to melamine cyanuric acid in adult mice induced thyroid dysfunction and circadian rhythm disorder

Ejemplares similares