Cumulative incidence and risk factors for radiation induced leukoencephalopathy in high grade glioma long term survivors

Abstract The incidence and risk factors associated with radiation-induced leukoencephalopathy (RIL) in long-term survivors of high-grade glioma (HGG) are still poorly investigated. We performed a retrospective research in our institutional database for patients with supratentorial HGG treated with f...

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Autores principales:	Robert Terziev, Dimitri Psimaras, Yannick Marie, Loic Feuvret, Giulia Berzero, Julian Jacob, Caroline Dehais, Flavie Bompaire, Wolf Mueller, Ben Kinnersley, Jean-Yves Delattre, Ahmed Idbaih, Khe Hoang-Xuan, Marc Sanson, Damien Ricard
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/44fb67f4c167463b87cf461b67e893f2
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spelling	oai:doaj.org-article:44fb67f4c167463b87cf461b67e893f22021-12-02T17:16:05ZCumulative incidence and risk factors for radiation induced leukoencephalopathy in high grade glioma long term survivors10.1038/s41598-021-89216-12045-2322https://doaj.org/article/44fb67f4c167463b87cf461b67e893f22021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-89216-1https://doaj.org/toc/2045-2322Abstract The incidence and risk factors associated with radiation-induced leukoencephalopathy (RIL) in long-term survivors of high-grade glioma (HGG) are still poorly investigated. We performed a retrospective research in our institutional database for patients with supratentorial HGG treated with focal radiotherapy, having a progression-free overall survival > 30 months and available germline DNA. We reviewed MRI scans for signs of leukoencephalopathy on T2/FLAIR sequences, and medical records for information on cerebrovascular risk factors and neurological symptoms. We investigated a panel of candidate single nucleotide polymorphisms (SNPs) to assess genetic risk. Eighty-one HGG patients (18 grade IV and 63 grade III, 50M/31F) were included in the study. The median age at the time of radiotherapy was 48 years old (range 18–69). The median follow-up after the completion of radiotherapy was 79 months. A total of 44 patients (44/81, 54.3%) developed RIL during follow-up. Twenty-nine of the 44 patients developed consistent symptoms such as subcortical dementia (n = 28), gait disturbances (n = 12), and urinary incontinence (n = 9). The cumulative incidence of RIL was 21% at 12 months, 42% at 36 months, and 48% at 60 months. Age > 60 years, smoking, and the germline SNP rs2120825 (PPARg locus) were associated with an increased risk of RIL. Our study identified potential risk factors for the development of RIL (age, smoking, and the germline SNP rs2120825) and established the rationale for testing PPARg agonists in the prevention and management of late-delayed radiation-induced neurotoxicity.Robert TerzievDimitri PsimarasYannick MarieLoic FeuvretGiulia BerzeroJulian JacobCaroline DehaisFlavie BompaireWolf MuellerBen KinnersleyJean-Yves DelattreAhmed IdbaihKhe Hoang-XuanMarc SansonDamien RicardNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Robert Terziev Dimitri Psimaras Yannick Marie Loic Feuvret Giulia Berzero Julian Jacob Caroline Dehais Flavie Bompaire Wolf Mueller Ben Kinnersley Jean-Yves Delattre Ahmed Idbaih Khe Hoang-Xuan Marc Sanson Damien Ricard Cumulative incidence and risk factors for radiation induced leukoencephalopathy in high grade glioma long term survivors
description	Abstract The incidence and risk factors associated with radiation-induced leukoencephalopathy (RIL) in long-term survivors of high-grade glioma (HGG) are still poorly investigated. We performed a retrospective research in our institutional database for patients with supratentorial HGG treated with focal radiotherapy, having a progression-free overall survival > 30 months and available germline DNA. We reviewed MRI scans for signs of leukoencephalopathy on T2/FLAIR sequences, and medical records for information on cerebrovascular risk factors and neurological symptoms. We investigated a panel of candidate single nucleotide polymorphisms (SNPs) to assess genetic risk. Eighty-one HGG patients (18 grade IV and 63 grade III, 50M/31F) were included in the study. The median age at the time of radiotherapy was 48 years old (range 18–69). The median follow-up after the completion of radiotherapy was 79 months. A total of 44 patients (44/81, 54.3%) developed RIL during follow-up. Twenty-nine of the 44 patients developed consistent symptoms such as subcortical dementia (n = 28), gait disturbances (n = 12), and urinary incontinence (n = 9). The cumulative incidence of RIL was 21% at 12 months, 42% at 36 months, and 48% at 60 months. Age > 60 years, smoking, and the germline SNP rs2120825 (PPARg locus) were associated with an increased risk of RIL. Our study identified potential risk factors for the development of RIL (age, smoking, and the germline SNP rs2120825) and established the rationale for testing PPARg agonists in the prevention and management of late-delayed radiation-induced neurotoxicity.
format	article
author	Robert Terziev Dimitri Psimaras Yannick Marie Loic Feuvret Giulia Berzero Julian Jacob Caroline Dehais Flavie Bompaire Wolf Mueller Ben Kinnersley Jean-Yves Delattre Ahmed Idbaih Khe Hoang-Xuan Marc Sanson Damien Ricard
author_facet	Robert Terziev Dimitri Psimaras Yannick Marie Loic Feuvret Giulia Berzero Julian Jacob Caroline Dehais Flavie Bompaire Wolf Mueller Ben Kinnersley Jean-Yves Delattre Ahmed Idbaih Khe Hoang-Xuan Marc Sanson Damien Ricard
author_sort	Robert Terziev
title	Cumulative incidence and risk factors for radiation induced leukoencephalopathy in high grade glioma long term survivors
title_short	Cumulative incidence and risk factors for radiation induced leukoencephalopathy in high grade glioma long term survivors
title_full	Cumulative incidence and risk factors for radiation induced leukoencephalopathy in high grade glioma long term survivors
title_fullStr	Cumulative incidence and risk factors for radiation induced leukoencephalopathy in high grade glioma long term survivors
title_full_unstemmed	Cumulative incidence and risk factors for radiation induced leukoencephalopathy in high grade glioma long term survivors
title_sort	cumulative incidence and risk factors for radiation induced leukoencephalopathy in high grade glioma long term survivors
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/44fb67f4c167463b87cf461b67e893f2
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Cumulative incidence and risk factors for radiation induced leukoencephalopathy in high grade glioma long term survivors

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