Genome-wide mega-analysis identifies 16 loci and highlights diverse biological mechanisms in the common epilepsies

Genome-wide mega-analysis identifies 16 loci and highlights diverse biological mechanisms in the common epilepsies

Epilepsies are common brain disorders and are classified based on clinical phenotyping, imaging and genetics. Here, the authors perform genome-wide association studies for 3 broad and 7 subtypes of epilepsy and identify 16 loci - 11 novel - that are further annotated by eQTL and partitioned heritabi...

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Auteur principal: The International League Against Epilepsy Consortium on Complex Epilepsies
Format: article
Langue:EN
Publié: Nature Portfolio 2018
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Science
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Accès en ligne:https://doaj.org/article/450148f9520f47a2a02f13cebc985c20
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id oai:doaj.org-article:450148f9520f47a2a02f13cebc985c20
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spelling oai:doaj.org-article:450148f9520f47a2a02f13cebc985c202021-12-02T14:39:27ZGenome-wide mega-analysis identifies 16 loci and highlights diverse biological mechanisms in the common epilepsies10.1038/s41467-018-07524-z2041-1723https://doaj.org/article/450148f9520f47a2a02f13cebc985c202018-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07524-zhttps://doaj.org/toc/2041-1723Epilepsies are common brain disorders and are classified based on clinical phenotyping, imaging and genetics. Here, the authors perform genome-wide association studies for 3 broad and 7 subtypes of epilepsy and identify 16 loci - 11 novel - that are further annotated by eQTL and partitioned heritability analyses.The International League Against Epilepsy Consortium on Complex EpilepsiesNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
The International League Against Epilepsy Consortium on Complex Epilepsies
Genome-wide mega-analysis identifies 16 loci and highlights diverse biological mechanisms in the common epilepsies
description Epilepsies are common brain disorders and are classified based on clinical phenotyping, imaging and genetics. Here, the authors perform genome-wide association studies for 3 broad and 7 subtypes of epilepsy and identify 16 loci - 11 novel - that are further annotated by eQTL and partitioned heritability analyses.
format article
author The International League Against Epilepsy Consortium on Complex Epilepsies
author_facet The International League Against Epilepsy Consortium on Complex Epilepsies
author_sort The International League Against Epilepsy Consortium on Complex Epilepsies
title Genome-wide mega-analysis identifies 16 loci and highlights diverse biological mechanisms in the common epilepsies
title_short Genome-wide mega-analysis identifies 16 loci and highlights diverse biological mechanisms in the common epilepsies
title_full Genome-wide mega-analysis identifies 16 loci and highlights diverse biological mechanisms in the common epilepsies
title_fullStr Genome-wide mega-analysis identifies 16 loci and highlights diverse biological mechanisms in the common epilepsies
title_full_unstemmed Genome-wide mega-analysis identifies 16 loci and highlights diverse biological mechanisms in the common epilepsies
title_sort genome-wide mega-analysis identifies 16 loci and highlights diverse biological mechanisms in the common epilepsies
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/450148f9520f47a2a02f13cebc985c20
work_keys_str_mv AT theinternationalleagueagainstepilepsyconsortiumoncomplexepilepsies genomewidemegaanalysisidentifies16lociandhighlightsdiversebiologicalmechanismsinthecommonepilepsies
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