Corticotropin-releasing hormone receptor 1 gene variants in irritable bowel syndrome.

<h4>Background</h4>Corticotropin-releasing hormone (CRH) acts mainly via the CRH receptor 1 (CRH-R1) and plays a crucial role in the stress-induced pathophysiology of irritable bowel syndrome (IBS). Several studies have demonstrated that variants of the CRH-R1 gene carry a potential risk...

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Autores principales:	Naoko Sato, Naoki Suzuki, Ayaka Sasaki, Emiko Aizawa, Takeshi Obayashi, Motoyori Kanazawa, Tomoko Mizuno, Michiko Kano, Masashi Aoki, Shin Fukudo
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4503c7cb6924498c9802e25a64ee5f91
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spelling	oai:doaj.org-article:4503c7cb6924498c9802e25a64ee5f912021-11-18T07:06:37ZCorticotropin-releasing hormone receptor 1 gene variants in irritable bowel syndrome.1932-620310.1371/journal.pone.0042450https://doaj.org/article/4503c7cb6924498c9802e25a64ee5f912012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22957021/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Corticotropin-releasing hormone (CRH) acts mainly via the CRH receptor 1 (CRH-R1) and plays a crucial role in the stress-induced pathophysiology of irritable bowel syndrome (IBS). Several studies have demonstrated that variants of the CRH-R1 gene carry a potential risk for depression, but evidence for an association between CRH-R1 genotypes and IBS is lacking. We tested the hypothesis that genetic polymorphisms and haplotypes of CRH-R1 moderate the IBS phenotype and negative emotion in IBS patients.<h4>Methods</h4>A total of 103 patients with IBS and 142 healthy controls participated in the study. Three single-nucleotide polymorphisms of the CRH-R1 gene (rs7209436, rs242924, and rs110402) were genotyped. Subjects' emotional states were evaluated using the Perceived-Stress Scale, the State-Trait Anxiety Inventory, and the Self-rating Depression Scale.<h4>Results</h4>The TT genotype of rs7209436 (P = 0.01) and rs242924 (P = 0.02) was significantly more common in patients with IBS than in controls. Total sample analysis showed significant association between bowel pattern (normal, diarrhea, constipation, or mixed symptoms) and the T allele of rs7209436 (P = 0.008), T allele of rs242924 (P = 0.019), A allele of rs110402 (P = 0.047), and TAT haplocopies (P = 0.048). Negative emotion was not associated with the examined CRH-R1 SNPs.<h4>Conclusion</h4>These findings suggest that genetic polymorphisms and the CRH-R1 haplotypes moderate IBS and related bowel patterns. There was no clear association between CRH-R1 genotypes and negative emotion accompanying IBS. Further studies on the CRH system are therefore warranted.Naoko SatoNaoki SuzukiAyaka SasakiEmiko AizawaTakeshi ObayashiMotoyori KanazawaTomoko MizunoMichiko KanoMasashi AokiShin FukudoPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 9, p e42450 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Naoko Sato Naoki Suzuki Ayaka Sasaki Emiko Aizawa Takeshi Obayashi Motoyori Kanazawa Tomoko Mizuno Michiko Kano Masashi Aoki Shin Fukudo Corticotropin-releasing hormone receptor 1 gene variants in irritable bowel syndrome.
description	<h4>Background</h4>Corticotropin-releasing hormone (CRH) acts mainly via the CRH receptor 1 (CRH-R1) and plays a crucial role in the stress-induced pathophysiology of irritable bowel syndrome (IBS). Several studies have demonstrated that variants of the CRH-R1 gene carry a potential risk for depression, but evidence for an association between CRH-R1 genotypes and IBS is lacking. We tested the hypothesis that genetic polymorphisms and haplotypes of CRH-R1 moderate the IBS phenotype and negative emotion in IBS patients.<h4>Methods</h4>A total of 103 patients with IBS and 142 healthy controls participated in the study. Three single-nucleotide polymorphisms of the CRH-R1 gene (rs7209436, rs242924, and rs110402) were genotyped. Subjects' emotional states were evaluated using the Perceived-Stress Scale, the State-Trait Anxiety Inventory, and the Self-rating Depression Scale.<h4>Results</h4>The TT genotype of rs7209436 (P = 0.01) and rs242924 (P = 0.02) was significantly more common in patients with IBS than in controls. Total sample analysis showed significant association between bowel pattern (normal, diarrhea, constipation, or mixed symptoms) and the T allele of rs7209436 (P = 0.008), T allele of rs242924 (P = 0.019), A allele of rs110402 (P = 0.047), and TAT haplocopies (P = 0.048). Negative emotion was not associated with the examined CRH-R1 SNPs.<h4>Conclusion</h4>These findings suggest that genetic polymorphisms and the CRH-R1 haplotypes moderate IBS and related bowel patterns. There was no clear association between CRH-R1 genotypes and negative emotion accompanying IBS. Further studies on the CRH system are therefore warranted.
format	article
author	Naoko Sato Naoki Suzuki Ayaka Sasaki Emiko Aizawa Takeshi Obayashi Motoyori Kanazawa Tomoko Mizuno Michiko Kano Masashi Aoki Shin Fukudo
author_facet	Naoko Sato Naoki Suzuki Ayaka Sasaki Emiko Aizawa Takeshi Obayashi Motoyori Kanazawa Tomoko Mizuno Michiko Kano Masashi Aoki Shin Fukudo
author_sort	Naoko Sato
title	Corticotropin-releasing hormone receptor 1 gene variants in irritable bowel syndrome.
title_short	Corticotropin-releasing hormone receptor 1 gene variants in irritable bowel syndrome.
title_full	Corticotropin-releasing hormone receptor 1 gene variants in irritable bowel syndrome.
title_fullStr	Corticotropin-releasing hormone receptor 1 gene variants in irritable bowel syndrome.
title_full_unstemmed	Corticotropin-releasing hormone receptor 1 gene variants in irritable bowel syndrome.
title_sort	corticotropin-releasing hormone receptor 1 gene variants in irritable bowel syndrome.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/4503c7cb6924498c9802e25a64ee5f91
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Corticotropin-releasing hormone receptor 1 gene variants in irritable bowel syndrome.

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