Pancreatic cancers suppress negative feedback of glucose transport to reprogram chromatin for metastasis

Distant metastases from pancreatic cancer patients were previously reported by the authors to be dependent on the glucose-metabolizing enzyme phosphogluconate dehydrogenase (PGD). Here the authors report a novel metabolic adaptation that that stably activates PGD to reprogram metastatic chromatin.

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Detalles Bibliográficos
Autores principales: Matthew E. Bechard, Rana Smalling, Akimasa Hayashi, Yi Zhong, Anna E. Word, Sydney L. Campbell, Amanda V. Tran, Vivian L. Weiss, Christine Iacobuzio-Donahue, Kathryn E. Wellen, Oliver G. McDonald
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/4506861df93c451294cd63802d5a994b
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Sumario:Distant metastases from pancreatic cancer patients were previously reported by the authors to be dependent on the glucose-metabolizing enzyme phosphogluconate dehydrogenase (PGD). Here the authors report a novel metabolic adaptation that that stably activates PGD to reprogram metastatic chromatin.