Pancreatic cancers suppress negative feedback of glucose transport to reprogram chromatin for metastasis

Distant metastases from pancreatic cancer patients were previously reported by the authors to be dependent on the glucose-metabolizing enzyme phosphogluconate dehydrogenase (PGD). Here the authors report a novel metabolic adaptation that that stably activates PGD to reprogram metastatic chromatin.

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Autores principales:	Matthew E. Bechard, Rana Smalling, Akimasa Hayashi, Yi Zhong, Anna E. Word, Sydney L. Campbell, Amanda V. Tran, Vivian L. Weiss, Christine Iacobuzio-Donahue, Kathryn E. Wellen, Oliver G. McDonald
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4506861df93c451294cd63802d5a994b
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spelling	oai:doaj.org-article:4506861df93c451294cd63802d5a994b2021-12-02T16:27:51ZPancreatic cancers suppress negative feedback of glucose transport to reprogram chromatin for metastasis10.1038/s41467-020-17839-52041-1723https://doaj.org/article/4506861df93c451294cd63802d5a994b2020-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17839-5https://doaj.org/toc/2041-1723Distant metastases from pancreatic cancer patients were previously reported by the authors to be dependent on the glucose-metabolizing enzyme phosphogluconate dehydrogenase (PGD). Here the authors report a novel metabolic adaptation that that stably activates PGD to reprogram metastatic chromatin.Matthew E. BechardRana SmallingAkimasa HayashiYi ZhongAnna E. WordSydney L. CampbellAmanda V. TranVivian L. WeissChristine Iacobuzio-DonahueKathryn E. WellenOliver G. McDonaldNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Matthew E. Bechard Rana Smalling Akimasa Hayashi Yi Zhong Anna E. Word Sydney L. Campbell Amanda V. Tran Vivian L. Weiss Christine Iacobuzio-Donahue Kathryn E. Wellen Oliver G. McDonald Pancreatic cancers suppress negative feedback of glucose transport to reprogram chromatin for metastasis
description	Distant metastases from pancreatic cancer patients were previously reported by the authors to be dependent on the glucose-metabolizing enzyme phosphogluconate dehydrogenase (PGD). Here the authors report a novel metabolic adaptation that that stably activates PGD to reprogram metastatic chromatin.
format	article
author	Matthew E. Bechard Rana Smalling Akimasa Hayashi Yi Zhong Anna E. Word Sydney L. Campbell Amanda V. Tran Vivian L. Weiss Christine Iacobuzio-Donahue Kathryn E. Wellen Oliver G. McDonald
author_facet	Matthew E. Bechard Rana Smalling Akimasa Hayashi Yi Zhong Anna E. Word Sydney L. Campbell Amanda V. Tran Vivian L. Weiss Christine Iacobuzio-Donahue Kathryn E. Wellen Oliver G. McDonald
author_sort	Matthew E. Bechard
title	Pancreatic cancers suppress negative feedback of glucose transport to reprogram chromatin for metastasis
title_short	Pancreatic cancers suppress negative feedback of glucose transport to reprogram chromatin for metastasis
title_full	Pancreatic cancers suppress negative feedback of glucose transport to reprogram chromatin for metastasis
title_fullStr	Pancreatic cancers suppress negative feedback of glucose transport to reprogram chromatin for metastasis
title_full_unstemmed	Pancreatic cancers suppress negative feedback of glucose transport to reprogram chromatin for metastasis
title_sort	pancreatic cancers suppress negative feedback of glucose transport to reprogram chromatin for metastasis
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/4506861df93c451294cd63802d5a994b
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Pancreatic cancers suppress negative feedback of glucose transport to reprogram chromatin for metastasis

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