Integrated Bioinformatic Analysis of SARS-CoV-2 Infection Related Genes ACE2, BSG and TMPRSS2 in Aerodigestive Cancers

Chaobin He,1– 3,* Xin Hua,1,2,4,* Shuxin Sun,1– 3,* Shaolong Li,1,2 Jun Wang,1– 3 Xin Huang1– 3 1Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, 510060, Peop...

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Autores principales:	He C, Hua X, Sun S, Li S, Wang J, Huang X
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	ace2 bsg tmprss2 covid-19 aerodigestive cancers Pathology RB1-214 Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/450799da343949dd859e4cba2358a321
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spelling	oai:doaj.org-article:450799da343949dd859e4cba2358a3212021-12-02T14:20:30ZIntegrated Bioinformatic Analysis of SARS-CoV-2 Infection Related Genes ACE2, BSG and TMPRSS2 in Aerodigestive Cancers1178-7031https://doaj.org/article/450799da343949dd859e4cba2358a3212021-03-01T00:00:00Zhttps://www.dovepress.com/integrated-bioinformatic-analysis-of-sars-cov-2-infection-related-gene-peer-reviewed-article-JIRhttps://doaj.org/toc/1178-7031Chaobin He,1– 3,* Xin Hua,1,2,4,* Shuxin Sun,1– 3,* Shaolong Li,1,2 Jun Wang,1– 3 Xin Huang1– 3 1Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, 510060, People’s Republic of China; 2Department of Experimental Research, Sun Yat-Sen University Cancer Center, Guangzhou, 510060, People’s Republic of China; 3Department of Pancreatobiliary Surgery, Sun Yat-Sen University Cancer Center, Guangzhou, 510060, People’s Republic of China; 4Department of Medical Oncology, Sun Yat-Sen University Cancer Center, Guangzhou, 510060, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xin HuangDepartment of Pancreatobiliary Surgery, Sun Yat-Sen University Cancer Center, Guangzhou, Guangdong, People’s Republic of ChinaEmail huangxin1@sysucc.org.cnBackground: Cancer patients are more vulnerable to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection than the general population, with lung epithelial cells or enterocytes being the main targets. However, the expressions of SARS-CoV-2 entry-related genes in aerodigestive cancers have not been fully elucidated.Methods: In this study, the expressions of SARS-CoV-2 receptors and cofactors, including angiotensin I-converting enzyme 2 (ACE2), basigin (BSG) and transmembrane serine protease 2 (TMPRSS2), were comprehensively assessed. We compared BSG and TMPRSS2 expressions between aerodigestive cancers and matched normal tissues through Gene Expression Profiling Interactive Analysis 2 (GEPIA2). Furthermore, expressions in healthy colon tissues at different anatomical locations were explored using the Genotype-Tissue Expression (GTEx) dataset. In addition, expressions among different tumor stages and the prognostic values were detected through GEPIA2. Moreover, the correlation between gene expression and immune infiltration was explored via Tumor Immune Estimation Resource (TIMER). Finally, expressions in primary colorectal cancer (CRC), lung metastasis and liver metastasis were investigated using the Gene Expression Omnibus (GEO) dataset GSE41258.Results: Similar to ACE2, TMPRSS2 and BSG were also highly expressed in the digestive tracts. Intriguingly, BSG/TMPRSS2 expression in adjacent normal colon tissue or lung tissue was higher than that in corresponding healthy tissue, whereas they varied not among different tumor stages and correlated not with prognosis in aerodigestive cancers. Moreover, ACE2 was expressed at higher levels in lung metastases from CRC than in normal lung tissues.Conclusion: SARS-CoV-2 entry genes were highly expressed in CRC, and we reported for the first time higher expression of ACE2 in lung metastases from CRC than in normal lung, indicating that these patients may be more susceptible to extrapulmonary or pulmonary SARS-CoV-2 infection. Since our study is a bioinformatic analysis, further experimental evidences and clinical data are urgently needed.Keywords: ACE2, BSG, TMPRSS2, COVID-19, aerodigestive cancersHe CHua XSun SLi SWang JHuang XDove Medical Pressarticleace2bsgtmprss2covid-19aerodigestive cancersPathologyRB1-214Therapeutics. PharmacologyRM1-950ENJournal of Inflammation Research, Vol Volume 14, Pp 791-802 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	ace2 bsg tmprss2 covid-19 aerodigestive cancers Pathology RB1-214 Therapeutics. Pharmacology RM1-950
spellingShingle	ace2 bsg tmprss2 covid-19 aerodigestive cancers Pathology RB1-214 Therapeutics. Pharmacology RM1-950 He C Hua X Sun S Li S Wang J Huang X Integrated Bioinformatic Analysis of SARS-CoV-2 Infection Related Genes ACE2, BSG and TMPRSS2 in Aerodigestive Cancers
description	Chaobin He,1– 3,* Xin Hua,1,2,4,* Shuxin Sun,1– 3,* Shaolong Li,1,2 Jun Wang,1– 3 Xin Huang1– 3 1Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, 510060, People’s Republic of China; 2Department of Experimental Research, Sun Yat-Sen University Cancer Center, Guangzhou, 510060, People’s Republic of China; 3Department of Pancreatobiliary Surgery, Sun Yat-Sen University Cancer Center, Guangzhou, 510060, People’s Republic of China; 4Department of Medical Oncology, Sun Yat-Sen University Cancer Center, Guangzhou, 510060, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xin HuangDepartment of Pancreatobiliary Surgery, Sun Yat-Sen University Cancer Center, Guangzhou, Guangdong, People’s Republic of ChinaEmail huangxin1@sysucc.org.cnBackground: Cancer patients are more vulnerable to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection than the general population, with lung epithelial cells or enterocytes being the main targets. However, the expressions of SARS-CoV-2 entry-related genes in aerodigestive cancers have not been fully elucidated.Methods: In this study, the expressions of SARS-CoV-2 receptors and cofactors, including angiotensin I-converting enzyme 2 (ACE2), basigin (BSG) and transmembrane serine protease 2 (TMPRSS2), were comprehensively assessed. We compared BSG and TMPRSS2 expressions between aerodigestive cancers and matched normal tissues through Gene Expression Profiling Interactive Analysis 2 (GEPIA2). Furthermore, expressions in healthy colon tissues at different anatomical locations were explored using the Genotype-Tissue Expression (GTEx) dataset. In addition, expressions among different tumor stages and the prognostic values were detected through GEPIA2. Moreover, the correlation between gene expression and immune infiltration was explored via Tumor Immune Estimation Resource (TIMER). Finally, expressions in primary colorectal cancer (CRC), lung metastasis and liver metastasis were investigated using the Gene Expression Omnibus (GEO) dataset GSE41258.Results: Similar to ACE2, TMPRSS2 and BSG were also highly expressed in the digestive tracts. Intriguingly, BSG/TMPRSS2 expression in adjacent normal colon tissue or lung tissue was higher than that in corresponding healthy tissue, whereas they varied not among different tumor stages and correlated not with prognosis in aerodigestive cancers. Moreover, ACE2 was expressed at higher levels in lung metastases from CRC than in normal lung tissues.Conclusion: SARS-CoV-2 entry genes were highly expressed in CRC, and we reported for the first time higher expression of ACE2 in lung metastases from CRC than in normal lung, indicating that these patients may be more susceptible to extrapulmonary or pulmonary SARS-CoV-2 infection. Since our study is a bioinformatic analysis, further experimental evidences and clinical data are urgently needed.Keywords: ACE2, BSG, TMPRSS2, COVID-19, aerodigestive cancers
format	article
author	He C Hua X Sun S Li S Wang J Huang X
author_facet	He C Hua X Sun S Li S Wang J Huang X
author_sort	He C
title	Integrated Bioinformatic Analysis of SARS-CoV-2 Infection Related Genes ACE2, BSG and TMPRSS2 in Aerodigestive Cancers
title_short	Integrated Bioinformatic Analysis of SARS-CoV-2 Infection Related Genes ACE2, BSG and TMPRSS2 in Aerodigestive Cancers
title_full	Integrated Bioinformatic Analysis of SARS-CoV-2 Infection Related Genes ACE2, BSG and TMPRSS2 in Aerodigestive Cancers
title_fullStr	Integrated Bioinformatic Analysis of SARS-CoV-2 Infection Related Genes ACE2, BSG and TMPRSS2 in Aerodigestive Cancers
title_full_unstemmed	Integrated Bioinformatic Analysis of SARS-CoV-2 Infection Related Genes ACE2, BSG and TMPRSS2 in Aerodigestive Cancers
title_sort	integrated bioinformatic analysis of sars-cov-2 infection related genes ace2, bsg and tmprss2 in aerodigestive cancers
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/450799da343949dd859e4cba2358a321
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Integrated Bioinformatic Analysis of SARS-CoV-2 Infection Related Genes ACE2, BSG and TMPRSS2 in Aerodigestive Cancers

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