The differences in homocysteine level between obstructive sleep apnea patients and controls: a meta-analysis.

<h4>Background</h4>Studies have reported inconsistent findings regarding the relationship between obstructive sleep apnea (OSA) and homocysteine (HCY) level. This study aimed to assess the difference in plasma HCY level between OSA patients and controls by conducting a meta-analysis of p...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Xun Niu, Xiong Chen, Ying Xiao, Jiaqi Dong, Rui Zhang, Meixia Lu, Weijia Kong
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4508bd263b814728b476245e85f6b286
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:4508bd263b814728b476245e85f6b286
record_format	dspace
spelling	oai:doaj.org-article:4508bd263b814728b476245e85f6b2862021-11-18T08:21:29ZThe differences in homocysteine level between obstructive sleep apnea patients and controls: a meta-analysis.1932-620310.1371/journal.pone.0095794https://doaj.org/article/4508bd263b814728b476245e85f6b2862014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24769854/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Studies have reported inconsistent findings regarding the relationship between obstructive sleep apnea (OSA) and homocysteine (HCY) level. This study aimed to assess the difference in plasma HCY level between OSA patients and controls by conducting a meta-analysis of published studies.<h4>Methods</h4>Database of PubMed, SCI, and China National Knowledge Internet (CNKI) were comprehensively searched. Eligible studies regarding plasma HCY level in OSA patients were identified by two independent reviewers. RevMan (version 5.2) and STATA (version 12.0) were employed for data synthesis.<h4>Results</h4>A total of 10 studies involving 432 subjects were included. Meta-analysis showed that plasma HCY levels in OSA group were 3.11 µmol/l higher than that in control group (95% confidence interval: 2.08 to 4.15, P<0.01). Subgroup analysis revealed a more significant differences between OSA patients and controls when average body mass index ≥ 30 (the total weighted mean difference (WMD) was 3.64), average age<50 (the total WMD was 3.96) and average apnea hypopnea index ≥ 35 (the total WMD was 4.54).<h4>Conclusions</h4>In this meta-analysis, plasma HCY levels were found to be higher in OSA patients compared to control subjects.Xun NiuXiong ChenYing XiaoJiaqi DongRui ZhangMeixia LuWeijia KongPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 4, p e95794 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Xun Niu Xiong Chen Ying Xiao Jiaqi Dong Rui Zhang Meixia Lu Weijia Kong The differences in homocysteine level between obstructive sleep apnea patients and controls: a meta-analysis.
description	<h4>Background</h4>Studies have reported inconsistent findings regarding the relationship between obstructive sleep apnea (OSA) and homocysteine (HCY) level. This study aimed to assess the difference in plasma HCY level between OSA patients and controls by conducting a meta-analysis of published studies.<h4>Methods</h4>Database of PubMed, SCI, and China National Knowledge Internet (CNKI) were comprehensively searched. Eligible studies regarding plasma HCY level in OSA patients were identified by two independent reviewers. RevMan (version 5.2) and STATA (version 12.0) were employed for data synthesis.<h4>Results</h4>A total of 10 studies involving 432 subjects were included. Meta-analysis showed that plasma HCY levels in OSA group were 3.11 µmol/l higher than that in control group (95% confidence interval: 2.08 to 4.15, P<0.01). Subgroup analysis revealed a more significant differences between OSA patients and controls when average body mass index ≥ 30 (the total weighted mean difference (WMD) was 3.64), average age<50 (the total WMD was 3.96) and average apnea hypopnea index ≥ 35 (the total WMD was 4.54).<h4>Conclusions</h4>In this meta-analysis, plasma HCY levels were found to be higher in OSA patients compared to control subjects.
format	article
author	Xun Niu Xiong Chen Ying Xiao Jiaqi Dong Rui Zhang Meixia Lu Weijia Kong
author_facet	Xun Niu Xiong Chen Ying Xiao Jiaqi Dong Rui Zhang Meixia Lu Weijia Kong
author_sort	Xun Niu
title	The differences in homocysteine level between obstructive sleep apnea patients and controls: a meta-analysis.
title_short	The differences in homocysteine level between obstructive sleep apnea patients and controls: a meta-analysis.
title_full	The differences in homocysteine level between obstructive sleep apnea patients and controls: a meta-analysis.
title_fullStr	The differences in homocysteine level between obstructive sleep apnea patients and controls: a meta-analysis.
title_full_unstemmed	The differences in homocysteine level between obstructive sleep apnea patients and controls: a meta-analysis.
title_sort	differences in homocysteine level between obstructive sleep apnea patients and controls: a meta-analysis.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/4508bd263b814728b476245e85f6b286
work_keys_str_mv	AT xunniu thedifferencesinhomocysteinelevelbetweenobstructivesleepapneapatientsandcontrolsametaanalysis AT xiongchen thedifferencesinhomocysteinelevelbetweenobstructivesleepapneapatientsandcontrolsametaanalysis AT yingxiao thedifferencesinhomocysteinelevelbetweenobstructivesleepapneapatientsandcontrolsametaanalysis AT jiaqidong thedifferencesinhomocysteinelevelbetweenobstructivesleepapneapatientsandcontrolsametaanalysis AT ruizhang thedifferencesinhomocysteinelevelbetweenobstructivesleepapneapatientsandcontrolsametaanalysis AT meixialu thedifferencesinhomocysteinelevelbetweenobstructivesleepapneapatientsandcontrolsametaanalysis AT weijiakong thedifferencesinhomocysteinelevelbetweenobstructivesleepapneapatientsandcontrolsametaanalysis AT xunniu differencesinhomocysteinelevelbetweenobstructivesleepapneapatientsandcontrolsametaanalysis AT xiongchen differencesinhomocysteinelevelbetweenobstructivesleepapneapatientsandcontrolsametaanalysis AT yingxiao differencesinhomocysteinelevelbetweenobstructivesleepapneapatientsandcontrolsametaanalysis AT jiaqidong differencesinhomocysteinelevelbetweenobstructivesleepapneapatientsandcontrolsametaanalysis AT ruizhang differencesinhomocysteinelevelbetweenobstructivesleepapneapatientsandcontrolsametaanalysis AT meixialu differencesinhomocysteinelevelbetweenobstructivesleepapneapatientsandcontrolsametaanalysis AT weijiakong differencesinhomocysteinelevelbetweenobstructivesleepapneapatientsandcontrolsametaanalysis
_version_	1718421856643448832

The differences in homocysteine level between obstructive sleep apnea patients and controls: a meta-analysis.

Ejemplares similares