Imaging multiple sclerosis pathology at 160 μm isotropic resolution by human whole-brain ex vivo magnetic resonance imaging at 3 T

Abstract Postmortem magnetic resonance imaging (MRI) of the fixed healthy and diseased human brain facilitates spatial resolutions and image quality that is not achievable with in vivo MRI scans. Though challenging—and almost exclusively performed at 7 T field strength—depicting the tissue architect...

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Autores principales:	Matthias Weigel, Peter Dechent, Riccardo Galbusera, Erik Bahn, Govind Nair, Po-Jui Lu, Ludwig Kappos, Wolfgang Brück, Christine Stadelmann, Cristina Granziera
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/450a8cb7872b40bf91203d860adc91df
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spelling	oai:doaj.org-article:450a8cb7872b40bf91203d860adc91df2021-12-02T18:46:59ZImaging multiple sclerosis pathology at 160 μm isotropic resolution by human whole-brain ex vivo magnetic resonance imaging at 3 T10.1038/s41598-021-94891-12045-2322https://doaj.org/article/450a8cb7872b40bf91203d860adc91df2021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-94891-1https://doaj.org/toc/2045-2322Abstract Postmortem magnetic resonance imaging (MRI) of the fixed healthy and diseased human brain facilitates spatial resolutions and image quality that is not achievable with in vivo MRI scans. Though challenging—and almost exclusively performed at 7 T field strength—depicting the tissue architecture of the entire brain in fine detail is invaluable since it enables the study of neuroanatomy and uncovers important pathological features in neurological disorders. The objectives of the present work were (1) to develop a 3D isotropic ultra-high-resolution imaging approach for human whole-brain ex vivo acquisitions working on a standard clinical 3 T MRI system; and (2) to explore the sensitivity and specificity of this concept for specific pathoanatomical features of multiple sclerosis. The reconstructed images demonstrate unprecedented resolution and soft tissue contrast of the diseased human brain at 3 T, thus allowing visualization of sub-millimetric lesions in the different cortical layers and in the cerebellar cortex, as well as unique cortical lesion characteristics such as the presence of incomplete/complete iron rims, and patterns of iron accumulation. Further details such as the subpial molecular layer, the line of Gennari, and some intrathalamic nuclei are also well distinguishable.Matthias WeigelPeter DechentRiccardo GalbuseraErik BahnGovind NairPo-Jui LuLudwig KapposWolfgang BrückChristine StadelmannCristina GranzieraNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Matthias Weigel Peter Dechent Riccardo Galbusera Erik Bahn Govind Nair Po-Jui Lu Ludwig Kappos Wolfgang Brück Christine Stadelmann Cristina Granziera Imaging multiple sclerosis pathology at 160 μm isotropic resolution by human whole-brain ex vivo magnetic resonance imaging at 3 T
description	Abstract Postmortem magnetic resonance imaging (MRI) of the fixed healthy and diseased human brain facilitates spatial resolutions and image quality that is not achievable with in vivo MRI scans. Though challenging—and almost exclusively performed at 7 T field strength—depicting the tissue architecture of the entire brain in fine detail is invaluable since it enables the study of neuroanatomy and uncovers important pathological features in neurological disorders. The objectives of the present work were (1) to develop a 3D isotropic ultra-high-resolution imaging approach for human whole-brain ex vivo acquisitions working on a standard clinical 3 T MRI system; and (2) to explore the sensitivity and specificity of this concept for specific pathoanatomical features of multiple sclerosis. The reconstructed images demonstrate unprecedented resolution and soft tissue contrast of the diseased human brain at 3 T, thus allowing visualization of sub-millimetric lesions in the different cortical layers and in the cerebellar cortex, as well as unique cortical lesion characteristics such as the presence of incomplete/complete iron rims, and patterns of iron accumulation. Further details such as the subpial molecular layer, the line of Gennari, and some intrathalamic nuclei are also well distinguishable.
format	article
author	Matthias Weigel Peter Dechent Riccardo Galbusera Erik Bahn Govind Nair Po-Jui Lu Ludwig Kappos Wolfgang Brück Christine Stadelmann Cristina Granziera
author_facet	Matthias Weigel Peter Dechent Riccardo Galbusera Erik Bahn Govind Nair Po-Jui Lu Ludwig Kappos Wolfgang Brück Christine Stadelmann Cristina Granziera
author_sort	Matthias Weigel
title	Imaging multiple sclerosis pathology at 160 μm isotropic resolution by human whole-brain ex vivo magnetic resonance imaging at 3 T
title_short	Imaging multiple sclerosis pathology at 160 μm isotropic resolution by human whole-brain ex vivo magnetic resonance imaging at 3 T
title_full	Imaging multiple sclerosis pathology at 160 μm isotropic resolution by human whole-brain ex vivo magnetic resonance imaging at 3 T
title_fullStr	Imaging multiple sclerosis pathology at 160 μm isotropic resolution by human whole-brain ex vivo magnetic resonance imaging at 3 T
title_full_unstemmed	Imaging multiple sclerosis pathology at 160 μm isotropic resolution by human whole-brain ex vivo magnetic resonance imaging at 3 T
title_sort	imaging multiple sclerosis pathology at 160 μm isotropic resolution by human whole-brain ex vivo magnetic resonance imaging at 3 t
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/450a8cb7872b40bf91203d860adc91df
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Imaging multiple sclerosis pathology at 160 μm isotropic resolution by human whole-brain ex vivo magnetic resonance imaging at 3 T

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