Myrmecodia platytyrea Methanol Tuber Extract Ameliorates Hyperglycemia In STZ-Induced Diabetic Sprague-Dawley Male Rats

Type 2 diabetes mellitus (T2DM) is one of the main non-communicable chronic diseases that has many complications that compromise the quality of life. Hence, the need to find alternatives to replace the current therapy or as an adjuvant. Tubers of Myrmecodia platytytrea (Rubiaceae) has been used trad...

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Autores principales:	Mizaton Hazizul Hasan, Hasbullani Zakaria, Ibtisam Abdul Wahab, Thellie Ponto, Aishah Adam
Formato:	article
Lenguaje:	EN
Publicado:	Universitas Gadjah Mada 2021
Materias:	streptozotocin antihyperglycaemic myrmecodia platytyrea t2dm stz-induced Pharmacy and materia medica RS1-441
Acceso en línea:	https://doaj.org/article/450ffde1ae15485d976509059f087778
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spelling	oai:doaj.org-article:450ffde1ae15485d976509059f0877782021-11-15T06:08:46ZMyrmecodia platytyrea Methanol Tuber Extract Ameliorates Hyperglycemia In STZ-Induced Diabetic Sprague-Dawley Male Rats2338-94272338-948610.22146/ijp.880https://doaj.org/article/450ffde1ae15485d976509059f0877782021-09-01T00:00:00Zhttps://jurnal.ugm.ac.id/v3/IJP/article/view/880https://doaj.org/toc/2338-9427https://doaj.org/toc/2338-9486Type 2 diabetes mellitus (T2DM) is one of the main non-communicable chronic diseases that has many complications that compromise the quality of life. Hence, the need to find alternatives to replace the current therapy or as an adjuvant. Tubers of Myrmecodia platytytrea (Rubiaceae) has been used traditionally as an alternative therapy for the management of cancer and other inflammatory-related disorders. The aim of this study was to investigate the potency of M. platytytrea methanolic tuber extract (MPMTE) as an antihyperglycemic agent, in vivo. :The streptozotocin (STZ)-induced diabetic rats were treated orally with MPMTE (100, 200 and 400 mg/kg) and metformin (positive control, 100 mg/kg) daily for 14 days. Blood glucose level and other biochemistry analysis were conducted including histological examination on liver, kidney and pancreas. The STZ-induced diabetic rats treated with MPMTE (200 and 400 mg/kg) had significant decreased (p<0.05) in fasting blood glucose, total cholesterol, triglycerides and low-density lipoprotein (LDL) with no significant changes in high-density lipoprotein (HDL) compared to STZ-induced untreated diabetic rats. Liver, kidney and pancreas were devoid of any damage caused by STZ. MPMTE had strong antihyperglycaemic activity and was protective against any STZ-induced organ damage. Thus, MPMTE can be further developed into an adjuvant therapy for diabetic patients.Mizaton Hazizul HasanHasbullani ZakariaIbtisam Abdul WahabThellie PontoAishah AdamUniversitas Gadjah Madaarticlestreptozotocinantihyperglycaemicmyrmecodia platytyreat2dmstz-inducedPharmacy and materia medicaRS1-441ENIndonesian Journal of Pharmacy, Pp 338-348 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	streptozotocin antihyperglycaemic myrmecodia platytyrea t2dm stz-induced Pharmacy and materia medica RS1-441
spellingShingle	streptozotocin antihyperglycaemic myrmecodia platytyrea t2dm stz-induced Pharmacy and materia medica RS1-441 Mizaton Hazizul Hasan Hasbullani Zakaria Ibtisam Abdul Wahab Thellie Ponto Aishah Adam Myrmecodia platytyrea Methanol Tuber Extract Ameliorates Hyperglycemia In STZ-Induced Diabetic Sprague-Dawley Male Rats
description	Type 2 diabetes mellitus (T2DM) is one of the main non-communicable chronic diseases that has many complications that compromise the quality of life. Hence, the need to find alternatives to replace the current therapy or as an adjuvant. Tubers of Myrmecodia platytytrea (Rubiaceae) has been used traditionally as an alternative therapy for the management of cancer and other inflammatory-related disorders. The aim of this study was to investigate the potency of M. platytytrea methanolic tuber extract (MPMTE) as an antihyperglycemic agent, in vivo. :The streptozotocin (STZ)-induced diabetic rats were treated orally with MPMTE (100, 200 and 400 mg/kg) and metformin (positive control, 100 mg/kg) daily for 14 days. Blood glucose level and other biochemistry analysis were conducted including histological examination on liver, kidney and pancreas. The STZ-induced diabetic rats treated with MPMTE (200 and 400 mg/kg) had significant decreased (p<0.05) in fasting blood glucose, total cholesterol, triglycerides and low-density lipoprotein (LDL) with no significant changes in high-density lipoprotein (HDL) compared to STZ-induced untreated diabetic rats. Liver, kidney and pancreas were devoid of any damage caused by STZ. MPMTE had strong antihyperglycaemic activity and was protective against any STZ-induced organ damage. Thus, MPMTE can be further developed into an adjuvant therapy for diabetic patients.
format	article
author	Mizaton Hazizul Hasan Hasbullani Zakaria Ibtisam Abdul Wahab Thellie Ponto Aishah Adam
author_facet	Mizaton Hazizul Hasan Hasbullani Zakaria Ibtisam Abdul Wahab Thellie Ponto Aishah Adam
author_sort	Mizaton Hazizul Hasan
title	Myrmecodia platytyrea Methanol Tuber Extract Ameliorates Hyperglycemia In STZ-Induced Diabetic Sprague-Dawley Male Rats
title_short	Myrmecodia platytyrea Methanol Tuber Extract Ameliorates Hyperglycemia In STZ-Induced Diabetic Sprague-Dawley Male Rats
title_full	Myrmecodia platytyrea Methanol Tuber Extract Ameliorates Hyperglycemia In STZ-Induced Diabetic Sprague-Dawley Male Rats
title_fullStr	Myrmecodia platytyrea Methanol Tuber Extract Ameliorates Hyperglycemia In STZ-Induced Diabetic Sprague-Dawley Male Rats
title_full_unstemmed	Myrmecodia platytyrea Methanol Tuber Extract Ameliorates Hyperglycemia In STZ-Induced Diabetic Sprague-Dawley Male Rats
title_sort	myrmecodia platytyrea methanol tuber extract ameliorates hyperglycemia in stz-induced diabetic sprague-dawley male rats
publisher	Universitas Gadjah Mada
publishDate	2021
url	https://doaj.org/article/450ffde1ae15485d976509059f087778
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Myrmecodia platytyrea Methanol Tuber Extract Ameliorates Hyperglycemia In STZ-Induced Diabetic Sprague-Dawley Male Rats

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