Role of cyclooxygenase-2-mediated prostaglandin E2-prostaglandin E receptor 4 signaling in cardiac reprogramming

Fibroblasts can be directly reprogrammed to cardiomyocytes, but reprogramming is less efficient for adult compared to embryonic fibroblasts. Here, the authors find that inhibition of inflammation and Cox-2-prostaglandin-cAMP-IL-1β signaling enhances reprogramming efficiency of adult, but not embryon...

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Autores principales:	Naoto Muraoka, Kaori Nara, Fumiya Tamura, Hidenori Kojima, Hiroyuki Yamakawa, Taketaro Sadahiro, Kazutaka Miyamoto, Mari Isomi, Sho Haginiwa, Hidenori Tani, Shota Kurotsu, Rina Osakabe, Satoru Torii, Shigeomi Shimizu, Hideyuki Okano, Yukihiko Sugimoto, Keiichi Fukuda, Masaki Ieda
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4512bbbc6b27484c935815f0bf1702ee
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spelling	oai:doaj.org-article:4512bbbc6b27484c935815f0bf1702ee2021-12-02T17:31:52ZRole of cyclooxygenase-2-mediated prostaglandin E2-prostaglandin E receptor 4 signaling in cardiac reprogramming10.1038/s41467-019-08626-y2041-1723https://doaj.org/article/4512bbbc6b27484c935815f0bf1702ee2019-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-08626-yhttps://doaj.org/toc/2041-1723Fibroblasts can be directly reprogrammed to cardiomyocytes, but reprogramming is less efficient for adult compared to embryonic fibroblasts. Here, the authors find that inhibition of inflammation and Cox-2-prostaglandin-cAMP-IL-1β signaling enhances reprogramming efficiency of adult, but not embryonic fibroblasts.Naoto MuraokaKaori NaraFumiya TamuraHidenori KojimaHiroyuki YamakawaTaketaro SadahiroKazutaka MiyamotoMari IsomiSho HaginiwaHidenori TaniShota KurotsuRina OsakabeSatoru ToriiShigeomi ShimizuHideyuki OkanoYukihiko SugimotoKeiichi FukudaMasaki IedaNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Naoto Muraoka Kaori Nara Fumiya Tamura Hidenori Kojima Hiroyuki Yamakawa Taketaro Sadahiro Kazutaka Miyamoto Mari Isomi Sho Haginiwa Hidenori Tani Shota Kurotsu Rina Osakabe Satoru Torii Shigeomi Shimizu Hideyuki Okano Yukihiko Sugimoto Keiichi Fukuda Masaki Ieda Role of cyclooxygenase-2-mediated prostaglandin E2-prostaglandin E receptor 4 signaling in cardiac reprogramming
description	Fibroblasts can be directly reprogrammed to cardiomyocytes, but reprogramming is less efficient for adult compared to embryonic fibroblasts. Here, the authors find that inhibition of inflammation and Cox-2-prostaglandin-cAMP-IL-1β signaling enhances reprogramming efficiency of adult, but not embryonic fibroblasts.
format	article
author	Naoto Muraoka Kaori Nara Fumiya Tamura Hidenori Kojima Hiroyuki Yamakawa Taketaro Sadahiro Kazutaka Miyamoto Mari Isomi Sho Haginiwa Hidenori Tani Shota Kurotsu Rina Osakabe Satoru Torii Shigeomi Shimizu Hideyuki Okano Yukihiko Sugimoto Keiichi Fukuda Masaki Ieda
author_facet	Naoto Muraoka Kaori Nara Fumiya Tamura Hidenori Kojima Hiroyuki Yamakawa Taketaro Sadahiro Kazutaka Miyamoto Mari Isomi Sho Haginiwa Hidenori Tani Shota Kurotsu Rina Osakabe Satoru Torii Shigeomi Shimizu Hideyuki Okano Yukihiko Sugimoto Keiichi Fukuda Masaki Ieda
author_sort	Naoto Muraoka
title	Role of cyclooxygenase-2-mediated prostaglandin E2-prostaglandin E receptor 4 signaling in cardiac reprogramming
title_short	Role of cyclooxygenase-2-mediated prostaglandin E2-prostaglandin E receptor 4 signaling in cardiac reprogramming
title_full	Role of cyclooxygenase-2-mediated prostaglandin E2-prostaglandin E receptor 4 signaling in cardiac reprogramming
title_fullStr	Role of cyclooxygenase-2-mediated prostaglandin E2-prostaglandin E receptor 4 signaling in cardiac reprogramming
title_full_unstemmed	Role of cyclooxygenase-2-mediated prostaglandin E2-prostaglandin E receptor 4 signaling in cardiac reprogramming
title_sort	role of cyclooxygenase-2-mediated prostaglandin e2-prostaglandin e receptor 4 signaling in cardiac reprogramming
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/4512bbbc6b27484c935815f0bf1702ee
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Role of cyclooxygenase-2-mediated prostaglandin E2-prostaglandin E receptor 4 signaling in cardiac reprogramming

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