An umpolung strategy to react catalytic enols with nucleophiles

Nucleophiles cannot be directly reacted with enolates due to polarity mismatching. Here, the authors developed an umpolung strategy for the selective synthesis of α-alkoxy carbonyl compounds by reaction of iridium enolates with nucleophilic alcohols promoted by an iodine(III) reagent.

Guardado en:

Detalles Bibliográficos
Autores principales:	Amparo Sanz-Marco, Samuel Martinez-Erro, Martin Pauze, Enrique Gómez-Bengoa, Belén Martín-Matute
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4512de0e8120421faf358a40d8a268ba
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:4512de0e8120421faf358a40d8a268ba
record_format	dspace
spelling	oai:doaj.org-article:4512de0e8120421faf358a40d8a268ba2021-12-02T15:35:27ZAn umpolung strategy to react catalytic enols with nucleophiles10.1038/s41467-019-13175-52041-1723https://doaj.org/article/4512de0e8120421faf358a40d8a268ba2019-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13175-5https://doaj.org/toc/2041-1723Nucleophiles cannot be directly reacted with enolates due to polarity mismatching. Here, the authors developed an umpolung strategy for the selective synthesis of α-alkoxy carbonyl compounds by reaction of iridium enolates with nucleophilic alcohols promoted by an iodine(III) reagent.Amparo Sanz-MarcoSamuel Martinez-ErroMartin PauzeEnrique Gómez-BengoaBelén Martín-MatuteNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-9 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Amparo Sanz-Marco Samuel Martinez-Erro Martin Pauze Enrique Gómez-Bengoa Belén Martín-Matute An umpolung strategy to react catalytic enols with nucleophiles
description	Nucleophiles cannot be directly reacted with enolates due to polarity mismatching. Here, the authors developed an umpolung strategy for the selective synthesis of α-alkoxy carbonyl compounds by reaction of iridium enolates with nucleophilic alcohols promoted by an iodine(III) reagent.
format	article
author	Amparo Sanz-Marco Samuel Martinez-Erro Martin Pauze Enrique Gómez-Bengoa Belén Martín-Matute
author_facet	Amparo Sanz-Marco Samuel Martinez-Erro Martin Pauze Enrique Gómez-Bengoa Belén Martín-Matute
author_sort	Amparo Sanz-Marco
title	An umpolung strategy to react catalytic enols with nucleophiles
title_short	An umpolung strategy to react catalytic enols with nucleophiles
title_full	An umpolung strategy to react catalytic enols with nucleophiles
title_fullStr	An umpolung strategy to react catalytic enols with nucleophiles
title_full_unstemmed	An umpolung strategy to react catalytic enols with nucleophiles
title_sort	umpolung strategy to react catalytic enols with nucleophiles
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/4512de0e8120421faf358a40d8a268ba
work_keys_str_mv	AT amparosanzmarco anumpolungstrategytoreactcatalyticenolswithnucleophiles AT samuelmartinezerro anumpolungstrategytoreactcatalyticenolswithnucleophiles AT martinpauze anumpolungstrategytoreactcatalyticenolswithnucleophiles AT enriquegomezbengoa anumpolungstrategytoreactcatalyticenolswithnucleophiles AT belenmartinmatute anumpolungstrategytoreactcatalyticenolswithnucleophiles AT amparosanzmarco umpolungstrategytoreactcatalyticenolswithnucleophiles AT samuelmartinezerro umpolungstrategytoreactcatalyticenolswithnucleophiles AT martinpauze umpolungstrategytoreactcatalyticenolswithnucleophiles AT enriquegomezbengoa umpolungstrategytoreactcatalyticenolswithnucleophiles AT belenmartinmatute umpolungstrategytoreactcatalyticenolswithnucleophiles
_version_	1718386528192823296

An umpolung strategy to react catalytic enols with nucleophiles

Ejemplares similares