Single-cell transcriptomics reveal the dynamic of haematopoietic stem cell production in the aorta

Haematopoietic stem cells (HSCs) are generated from haemogenic endothelial (HE) cells in vertebrate embryo aortas. Here, the authors perform single-cell RNA-sequencing of cells isolated from embryonic mouse aortas to identify genes and transcription factor networks activated during the endothelial-t...

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Autores principales:	Chloé S. Baron, Lennart Kester, Anna Klaus, Jean-Charles Boisset, Roshana Thambyrajah, Laurent Yvernogeau, Valérie Kouskoff, Georges Lacaud, Alexander van Oudenaarden, Catherine Robin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4516f07ece7948e38c05b6fb0a306c87
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spelling	oai:doaj.org-article:4516f07ece7948e38c05b6fb0a306c872021-12-02T15:33:55ZSingle-cell transcriptomics reveal the dynamic of haematopoietic stem cell production in the aorta10.1038/s41467-018-04893-32041-1723https://doaj.org/article/4516f07ece7948e38c05b6fb0a306c872018-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04893-3https://doaj.org/toc/2041-1723Haematopoietic stem cells (HSCs) are generated from haemogenic endothelial (HE) cells in vertebrate embryo aortas. Here, the authors perform single-cell RNA-sequencing of cells isolated from embryonic mouse aortas to identify genes and transcription factor networks activated during the endothelial-to-haematopoietic switch.Chloé S. BaronLennart KesterAnna KlausJean-Charles BoissetRoshana ThambyrajahLaurent YvernogeauValérie KouskoffGeorges LacaudAlexander van OudenaardenCatherine RobinNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Chloé S. Baron Lennart Kester Anna Klaus Jean-Charles Boisset Roshana Thambyrajah Laurent Yvernogeau Valérie Kouskoff Georges Lacaud Alexander van Oudenaarden Catherine Robin Single-cell transcriptomics reveal the dynamic of haematopoietic stem cell production in the aorta
description	Haematopoietic stem cells (HSCs) are generated from haemogenic endothelial (HE) cells in vertebrate embryo aortas. Here, the authors perform single-cell RNA-sequencing of cells isolated from embryonic mouse aortas to identify genes and transcription factor networks activated during the endothelial-to-haematopoietic switch.
format	article
author	Chloé S. Baron Lennart Kester Anna Klaus Jean-Charles Boisset Roshana Thambyrajah Laurent Yvernogeau Valérie Kouskoff Georges Lacaud Alexander van Oudenaarden Catherine Robin
author_facet	Chloé S. Baron Lennart Kester Anna Klaus Jean-Charles Boisset Roshana Thambyrajah Laurent Yvernogeau Valérie Kouskoff Georges Lacaud Alexander van Oudenaarden Catherine Robin
author_sort	Chloé S. Baron
title	Single-cell transcriptomics reveal the dynamic of haematopoietic stem cell production in the aorta
title_short	Single-cell transcriptomics reveal the dynamic of haematopoietic stem cell production in the aorta
title_full	Single-cell transcriptomics reveal the dynamic of haematopoietic stem cell production in the aorta
title_fullStr	Single-cell transcriptomics reveal the dynamic of haematopoietic stem cell production in the aorta
title_full_unstemmed	Single-cell transcriptomics reveal the dynamic of haematopoietic stem cell production in the aorta
title_sort	single-cell transcriptomics reveal the dynamic of haematopoietic stem cell production in the aorta
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/4516f07ece7948e38c05b6fb0a306c87
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Single-cell transcriptomics reveal the dynamic of haematopoietic stem cell production in the aorta

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