Etiological and Clinical Evaluations of Patients with Acute Allograft Dysfunction Within the First Year Address

Aim:Kidney transplantation is the most preferred long-term treatment of children with end stage renal disease since 1954. Graft dysfunction has been divided into three categories based on timing of presentation. In this article, we aim to present the etiologic factors of acute graft dysfunction in t...

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Autores principales:	Eren Soyaltın, Caner Alparslan, Önder Yavaşcan, Belde Kasap Demir, Seçil Arslansoyu Çamlar, Demet Alaygut, Tunç Özdemir, Fatma Mutlubaş
Formato:	article
Lenguaje:	EN TR
Publicado:	Galenos Yayinevi 2021
Materias:	renal transplantation children acute graft dysfunction Medicine R Pediatrics RJ1-570
Acceso en línea:	https://doaj.org/article/4517d6e77af14e568e930bebb5053cf8
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spelling	oai:doaj.org-article:4517d6e77af14e568e930bebb5053cf82021-11-11T11:27:23ZEtiological and Clinical Evaluations of Patients with Acute Allograft Dysfunction Within the First Year Address2147-94452587-247810.4274/jpr.galenos.2020.15985https://doaj.org/article/4517d6e77af14e568e930bebb5053cf82021-12-01T00:00:00Z http://jpedres.org/archives/archive-detail/article-preview/etiological-and-clinical-evaluations-of-patients-w/49625 https://doaj.org/toc/2147-9445https://doaj.org/toc/2587-2478Aim:Kidney transplantation is the most preferred long-term treatment of children with end stage renal disease since 1954. Graft dysfunction has been divided into three categories based on timing of presentation. In this article, we aim to present the etiologic factors of acute graft dysfunction in the first year of renal transplantation in children.Materials and Methods:The patients, diagnosed with acute allograft dysfunction in first year of kidney transplantation, in University of Health Sciences Turkey, Tepecik Training and Research Hospital between March 2005 and October 2017 were analyzed prospectively in this study.Results:Over the 15 year period, 56 pediatric renal allograft patients were followed in University of Health Sciences Turkey, Tepecik Training and Research Hospital. During this period, 25 patients had diagnosed with early allograft dysfunction. Five patients were admitted two times in a year with allograft dysfunction. The mean age of patients was 12.6 (4.0±21.0) years, with a male and female ratio of 17:8. Delayed graft function was occurred in four patients (16%). Among 25 renal allograft recipients showed early graft dysfunction on average of 4.2 months (1-10 months) after transplantation. The etiology of early graft dysfunction showed 10% immunologic diseases and 90% non-immunologic factors. Five patients (16.7%) diagnosed with urinary tract infection, one patient (3.3%) diagnosed with cytomegalovirus nephropathy, five patients (16.7%) diagnosed with BK nephropathy, eight patients (26.7%) diagnosed with acute cyclosporine toxicity, seven patients (23.3%) were diagnosed with dehydration and one patient (3.3%) diagnosed with urologic anomalies. Twelve patients had performed renal allograft biopsy. The histological findings were consistent with T-cell mediated rejection in two patients; B-cell mediated rejection in one patient and viral nephropathy in five patients. Non-specific histological findings were determined in five patients.Conclusion:Early recognition of the etiology of graft dysfunction that develops at 1 year and appropriate treatment will contribute to the preservation of long-term graft dysfunction.Eren SoyaltınCaner AlparslanÖnder YavaşcanBelde Kasap DemirSeçil Arslansoyu ÇamlarDemet AlaygutTunç ÖzdemirFatma MutlubaşGalenos Yayineviarticlerenal transplantationchildrenacute graft dysfunctionMedicineRPediatricsRJ1-570ENTRJournal of Pediatric Research, Vol 8, Iss 4, Pp 382-388 (2021)
institution	DOAJ
collection	DOAJ
language	EN TR
topic	renal transplantation children acute graft dysfunction Medicine R Pediatrics RJ1-570
spellingShingle	renal transplantation children acute graft dysfunction Medicine R Pediatrics RJ1-570 Eren Soyaltın Caner Alparslan Önder Yavaşcan Belde Kasap Demir Seçil Arslansoyu Çamlar Demet Alaygut Tunç Özdemir Fatma Mutlubaş Etiological and Clinical Evaluations of Patients with Acute Allograft Dysfunction Within the First Year Address
description	Aim:Kidney transplantation is the most preferred long-term treatment of children with end stage renal disease since 1954. Graft dysfunction has been divided into three categories based on timing of presentation. In this article, we aim to present the etiologic factors of acute graft dysfunction in the first year of renal transplantation in children.Materials and Methods:The patients, diagnosed with acute allograft dysfunction in first year of kidney transplantation, in University of Health Sciences Turkey, Tepecik Training and Research Hospital between March 2005 and October 2017 were analyzed prospectively in this study.Results:Over the 15 year period, 56 pediatric renal allograft patients were followed in University of Health Sciences Turkey, Tepecik Training and Research Hospital. During this period, 25 patients had diagnosed with early allograft dysfunction. Five patients were admitted two times in a year with allograft dysfunction. The mean age of patients was 12.6 (4.0±21.0) years, with a male and female ratio of 17:8. Delayed graft function was occurred in four patients (16%). Among 25 renal allograft recipients showed early graft dysfunction on average of 4.2 months (1-10 months) after transplantation. The etiology of early graft dysfunction showed 10% immunologic diseases and 90% non-immunologic factors. Five patients (16.7%) diagnosed with urinary tract infection, one patient (3.3%) diagnosed with cytomegalovirus nephropathy, five patients (16.7%) diagnosed with BK nephropathy, eight patients (26.7%) diagnosed with acute cyclosporine toxicity, seven patients (23.3%) were diagnosed with dehydration and one patient (3.3%) diagnosed with urologic anomalies. Twelve patients had performed renal allograft biopsy. The histological findings were consistent with T-cell mediated rejection in two patients; B-cell mediated rejection in one patient and viral nephropathy in five patients. Non-specific histological findings were determined in five patients.Conclusion:Early recognition of the etiology of graft dysfunction that develops at 1 year and appropriate treatment will contribute to the preservation of long-term graft dysfunction.
format	article
author	Eren Soyaltın Caner Alparslan Önder Yavaşcan Belde Kasap Demir Seçil Arslansoyu Çamlar Demet Alaygut Tunç Özdemir Fatma Mutlubaş
author_facet	Eren Soyaltın Caner Alparslan Önder Yavaşcan Belde Kasap Demir Seçil Arslansoyu Çamlar Demet Alaygut Tunç Özdemir Fatma Mutlubaş
author_sort	Eren Soyaltın
title	Etiological and Clinical Evaluations of Patients with Acute Allograft Dysfunction Within the First Year Address
title_short	Etiological and Clinical Evaluations of Patients with Acute Allograft Dysfunction Within the First Year Address
title_full	Etiological and Clinical Evaluations of Patients with Acute Allograft Dysfunction Within the First Year Address
title_fullStr	Etiological and Clinical Evaluations of Patients with Acute Allograft Dysfunction Within the First Year Address
title_full_unstemmed	Etiological and Clinical Evaluations of Patients with Acute Allograft Dysfunction Within the First Year Address
title_sort	etiological and clinical evaluations of patients with acute allograft dysfunction within the first year address
publisher	Galenos Yayinevi
publishDate	2021
url	https://doaj.org/article/4517d6e77af14e568e930bebb5053cf8
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Etiological and Clinical Evaluations of Patients with Acute Allograft Dysfunction Within the First Year Address

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