Allosteric coupling of sub-millisecond clamshell motions in ionotropic glutamate receptor ligand-binding domains

Rajab et al. study the dynamics of closure of ligand binding domains (LBD) of the three major ionotropic glutamate receptor subtypes. They find pronounced sub-millisecond fluctuations in the apo state of LBDs from all three sub-types and reveal a pathway of allosteric communication in LBD dynamics a...

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Autores principales:	Suhaila Rajab, Leah Bismin, Simone Schwarze, Alexandra Pinggera, Ingo H. Greger, Hannes Neuweiler
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/45196b358d364aed804825cf7924fb17
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spelling	oai:doaj.org-article:45196b358d364aed804825cf7924fb172021-12-02T17:19:12ZAllosteric coupling of sub-millisecond clamshell motions in ionotropic glutamate receptor ligand-binding domains10.1038/s42003-021-02605-02399-3642https://doaj.org/article/45196b358d364aed804825cf7924fb172021-09-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02605-0https://doaj.org/toc/2399-3642Rajab et al. study the dynamics of closure of ligand binding domains (LBD) of the three major ionotropic glutamate receptor subtypes. They find pronounced sub-millisecond fluctuations in the apo state of LBDs from all three sub-types and reveal a pathway of allosteric communication in LBD dynamics across the dimerization interfaceSuhaila RajabLeah BisminSimone SchwarzeAlexandra PinggeraIngo H. GregerHannes NeuweilerNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Suhaila Rajab Leah Bismin Simone Schwarze Alexandra Pinggera Ingo H. Greger Hannes Neuweiler Allosteric coupling of sub-millisecond clamshell motions in ionotropic glutamate receptor ligand-binding domains
description	Rajab et al. study the dynamics of closure of ligand binding domains (LBD) of the three major ionotropic glutamate receptor subtypes. They find pronounced sub-millisecond fluctuations in the apo state of LBDs from all three sub-types and reveal a pathway of allosteric communication in LBD dynamics across the dimerization interface
format	article
author	Suhaila Rajab Leah Bismin Simone Schwarze Alexandra Pinggera Ingo H. Greger Hannes Neuweiler
author_facet	Suhaila Rajab Leah Bismin Simone Schwarze Alexandra Pinggera Ingo H. Greger Hannes Neuweiler
author_sort	Suhaila Rajab
title	Allosteric coupling of sub-millisecond clamshell motions in ionotropic glutamate receptor ligand-binding domains
title_short	Allosteric coupling of sub-millisecond clamshell motions in ionotropic glutamate receptor ligand-binding domains
title_full	Allosteric coupling of sub-millisecond clamshell motions in ionotropic glutamate receptor ligand-binding domains
title_fullStr	Allosteric coupling of sub-millisecond clamshell motions in ionotropic glutamate receptor ligand-binding domains
title_full_unstemmed	Allosteric coupling of sub-millisecond clamshell motions in ionotropic glutamate receptor ligand-binding domains
title_sort	allosteric coupling of sub-millisecond clamshell motions in ionotropic glutamate receptor ligand-binding domains
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/45196b358d364aed804825cf7924fb17
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Allosteric coupling of sub-millisecond clamshell motions in ionotropic glutamate receptor ligand-binding domains

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