Submicron-Sized Vermiculite Assisted Oregano Oil for Controlled Release and Long-Term Bacterial Inhibition

Oregano essential oil (OEO) is a natural compound consisting of potent antibiotic molecules. Its volatility is the major obstacle against the transportation and anti-bacterial performance. In this work, submicron-sized vermiculite (SMV) particles were prepared from Australian vermiculite clay by bal...

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Autores principales:	Sukitha Geethma Kothalawala, Jun Zhang, Yue Wang, Chengzhong Yu
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	vermiculite oregano essential oil antibacterial ball milling volatility Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/451a0b00bfc04f579df23998e1102ca1
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id	oai:doaj.org-article:451a0b00bfc04f579df23998e1102ca1
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spelling	oai:doaj.org-article:451a0b00bfc04f579df23998e1102ca12021-11-25T16:22:51ZSubmicron-Sized Vermiculite Assisted Oregano Oil for Controlled Release and Long-Term Bacterial Inhibition10.3390/antibiotics101113242079-6382https://doaj.org/article/451a0b00bfc04f579df23998e1102ca12021-10-01T00:00:00Zhttps://www.mdpi.com/2079-6382/10/11/1324https://doaj.org/toc/2079-6382Oregano essential oil (OEO) is a natural compound consisting of potent antibiotic molecules. Its volatility is the major obstacle against the transportation and anti-bacterial performance. In this work, submicron-sized vermiculite (SMV) particles were prepared from Australian vermiculite clay by ball milling, and tested as a potential particulate-carrier for OEO. The loading of OEO by SMV can be easily achieved by mechanical mixing. Compared to raw vermiculite and free OEO, the OEO-loaded SMV displayed sustained isothermal release behaviour of OEO and demonstrated enhanced antibacterial performance in in vitro antibacterial tests against <i>Escherichia coli</i> (<i>E. coli</i>) and <i>Staphylococcus</i> <i>epidermidis</i> (<i>S. epidermidis</i>). This study provides a facile and commercially viable approach in designing advantageous carriers for volatile actives in antimicrobial applications.Sukitha Geethma KothalawalaJun ZhangYue WangChengzhong YuMDPI AGarticlevermiculiteoregano essential oilantibacterialball millingvolatilityTherapeutics. PharmacologyRM1-950ENAntibiotics, Vol 10, Iss 1324, p 1324 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	vermiculite oregano essential oil antibacterial ball milling volatility Therapeutics. Pharmacology RM1-950
spellingShingle	vermiculite oregano essential oil antibacterial ball milling volatility Therapeutics. Pharmacology RM1-950 Sukitha Geethma Kothalawala Jun Zhang Yue Wang Chengzhong Yu Submicron-Sized Vermiculite Assisted Oregano Oil for Controlled Release and Long-Term Bacterial Inhibition
description	Oregano essential oil (OEO) is a natural compound consisting of potent antibiotic molecules. Its volatility is the major obstacle against the transportation and anti-bacterial performance. In this work, submicron-sized vermiculite (SMV) particles were prepared from Australian vermiculite clay by ball milling, and tested as a potential particulate-carrier for OEO. The loading of OEO by SMV can be easily achieved by mechanical mixing. Compared to raw vermiculite and free OEO, the OEO-loaded SMV displayed sustained isothermal release behaviour of OEO and demonstrated enhanced antibacterial performance in in vitro antibacterial tests against <i>Escherichia coli</i> (<i>E. coli</i>) and <i>Staphylococcus</i> <i>epidermidis</i> (<i>S. epidermidis</i>). This study provides a facile and commercially viable approach in designing advantageous carriers for volatile actives in antimicrobial applications.
format	article
author	Sukitha Geethma Kothalawala Jun Zhang Yue Wang Chengzhong Yu
author_facet	Sukitha Geethma Kothalawala Jun Zhang Yue Wang Chengzhong Yu
author_sort	Sukitha Geethma Kothalawala
title	Submicron-Sized Vermiculite Assisted Oregano Oil for Controlled Release and Long-Term Bacterial Inhibition
title_short	Submicron-Sized Vermiculite Assisted Oregano Oil for Controlled Release and Long-Term Bacterial Inhibition
title_full	Submicron-Sized Vermiculite Assisted Oregano Oil for Controlled Release and Long-Term Bacterial Inhibition
title_fullStr	Submicron-Sized Vermiculite Assisted Oregano Oil for Controlled Release and Long-Term Bacterial Inhibition
title_full_unstemmed	Submicron-Sized Vermiculite Assisted Oregano Oil for Controlled Release and Long-Term Bacterial Inhibition
title_sort	submicron-sized vermiculite assisted oregano oil for controlled release and long-term bacterial inhibition
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/451a0b00bfc04f579df23998e1102ca1
work_keys_str_mv	AT sukithageethmakothalawala submicronsizedvermiculiteassistedoreganooilforcontrolledreleaseandlongtermbacterialinhibition AT junzhang submicronsizedvermiculiteassistedoreganooilforcontrolledreleaseandlongtermbacterialinhibition AT yuewang submicronsizedvermiculiteassistedoreganooilforcontrolledreleaseandlongtermbacterialinhibition AT chengzhongyu submicronsizedvermiculiteassistedoreganooilforcontrolledreleaseandlongtermbacterialinhibition
_version_	1718413194904469504

Submicron-Sized Vermiculite Assisted Oregano Oil for Controlled Release and Long-Term Bacterial Inhibition

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