Early intervention with Bifidobacterium lactis NCC2818 modulates the host-microbe interface independent of the sustained changes induced by the neonatal environment

Abstract Inflammatory and metabolic diseases can originate during early-life and have been correlated with shifts in intestinal microbial ecology. Here we demonstrate that minor environmental fluctuations during the early neonatal period had sustained effects on the developing porcine microbiota and...

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Autores principales:	Marie C. Lewis, Claire A. Merrifield, Bernard Berger, Olivier Cloarec, Swantje Duncker, Annick Mercenier, Jeremy K. Nicholson, Elaine Holmes, Mick Bailey
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/451a34b2ca9040fc9f053fddee2703ec
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spelling	oai:doaj.org-article:451a34b2ca9040fc9f053fddee2703ec2021-12-02T15:04:58ZEarly intervention with Bifidobacterium lactis NCC2818 modulates the host-microbe interface independent of the sustained changes induced by the neonatal environment10.1038/s41598-017-05689-z2045-2322https://doaj.org/article/451a34b2ca9040fc9f053fddee2703ec2017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-05689-zhttps://doaj.org/toc/2045-2322Abstract Inflammatory and metabolic diseases can originate during early-life and have been correlated with shifts in intestinal microbial ecology. Here we demonstrate that minor environmental fluctuations during the early neonatal period had sustained effects on the developing porcine microbiota and host-microbe interface. These inter-replicate effects appear to originate during the first day of life, and are likely to reflect very early microbiota acquisition from the environment. We statistically link early systemic inflammation with later local increases in inflammatory cytokine (IL-17) production, which could have important enteric health implications. Immunity, intestinal barrier function, host metabolism and host-microbiota co-metabolism were further modified by Bifidobacterium lactis NCC2818 supplementation, although composition of the in situ microbiota remained unchanged. Finally, our robust model identified novel, strong correlations between urinary metabolites (eg malonate, phenylacetylglycine, alanine) and mucosal immunoglobulin (IgM) and cytokine (IL-10, IL-4) production, thus providing the possibility of the development of urinary ‘dipstick’ tests to assess non-accessible mucosal immune development and identify early precursors (biomarkers) of disease. These results have important implications for infants exposed to neonatal factors including caesarean delivery, antibiotic therapy and delayed discharge from hospital environments, which may predispose to the development of inflammatory and metabolic diseases in later life.Marie C. LewisClaire A. MerrifieldBernard BergerOlivier CloarecSwantje DunckerAnnick MercenierJeremy K. NicholsonElaine HolmesMick BaileyNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Marie C. Lewis Claire A. Merrifield Bernard Berger Olivier Cloarec Swantje Duncker Annick Mercenier Jeremy K. Nicholson Elaine Holmes Mick Bailey Early intervention with Bifidobacterium lactis NCC2818 modulates the host-microbe interface independent of the sustained changes induced by the neonatal environment
description	Abstract Inflammatory and metabolic diseases can originate during early-life and have been correlated with shifts in intestinal microbial ecology. Here we demonstrate that minor environmental fluctuations during the early neonatal period had sustained effects on the developing porcine microbiota and host-microbe interface. These inter-replicate effects appear to originate during the first day of life, and are likely to reflect very early microbiota acquisition from the environment. We statistically link early systemic inflammation with later local increases in inflammatory cytokine (IL-17) production, which could have important enteric health implications. Immunity, intestinal barrier function, host metabolism and host-microbiota co-metabolism were further modified by Bifidobacterium lactis NCC2818 supplementation, although composition of the in situ microbiota remained unchanged. Finally, our robust model identified novel, strong correlations between urinary metabolites (eg malonate, phenylacetylglycine, alanine) and mucosal immunoglobulin (IgM) and cytokine (IL-10, IL-4) production, thus providing the possibility of the development of urinary ‘dipstick’ tests to assess non-accessible mucosal immune development and identify early precursors (biomarkers) of disease. These results have important implications for infants exposed to neonatal factors including caesarean delivery, antibiotic therapy and delayed discharge from hospital environments, which may predispose to the development of inflammatory and metabolic diseases in later life.
format	article
author	Marie C. Lewis Claire A. Merrifield Bernard Berger Olivier Cloarec Swantje Duncker Annick Mercenier Jeremy K. Nicholson Elaine Holmes Mick Bailey
author_facet	Marie C. Lewis Claire A. Merrifield Bernard Berger Olivier Cloarec Swantje Duncker Annick Mercenier Jeremy K. Nicholson Elaine Holmes Mick Bailey
author_sort	Marie C. Lewis
title	Early intervention with Bifidobacterium lactis NCC2818 modulates the host-microbe interface independent of the sustained changes induced by the neonatal environment
title_short	Early intervention with Bifidobacterium lactis NCC2818 modulates the host-microbe interface independent of the sustained changes induced by the neonatal environment
title_full	Early intervention with Bifidobacterium lactis NCC2818 modulates the host-microbe interface independent of the sustained changes induced by the neonatal environment
title_fullStr	Early intervention with Bifidobacterium lactis NCC2818 modulates the host-microbe interface independent of the sustained changes induced by the neonatal environment
title_full_unstemmed	Early intervention with Bifidobacterium lactis NCC2818 modulates the host-microbe interface independent of the sustained changes induced by the neonatal environment
title_sort	early intervention with bifidobacterium lactis ncc2818 modulates the host-microbe interface independent of the sustained changes induced by the neonatal environment
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/451a34b2ca9040fc9f053fddee2703ec
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Early intervention with Bifidobacterium lactis NCC2818 modulates the host-microbe interface independent of the sustained changes induced by the neonatal environment

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