Alternative lengthening of telomeres in childhood neuroblastoma from genome to proteome
Alternative lengthening of telomeres (ALT) is associated with a poor outcome in neuroblastoma. Here, the authors find that ALT is associated with mutated ATRX and/or reduced protein abundance, frequent telomeric repeat loci and heterochromatic telomeric chromatin.
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2021
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oai:doaj.org-article:451b2c4a26e94327b98d615c78ab75da2021-12-02T13:14:59ZAlternative lengthening of telomeres in childhood neuroblastoma from genome to proteome10.1038/s41467-021-21247-82041-1723https://doaj.org/article/451b2c4a26e94327b98d615c78ab75da2021-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21247-8https://doaj.org/toc/2041-1723Alternative lengthening of telomeres (ALT) is associated with a poor outcome in neuroblastoma. Here, the authors find that ALT is associated with mutated ATRX and/or reduced protein abundance, frequent telomeric repeat loci and heterochromatic telomeric chromatin.Sabine A. HartliebLina SieverlingMichal Nadler-HollyMatthias ZiehmUmut H. ToprakCarl HerrmannNaveed IshaqueKonstantin OkonechnikovMoritz GartlgruberYoung-Gyu ParkElisa Maria WechtLarissa SavelyevaKai-Oliver HenrichCarolina RosswogMatthias FischerBarbara HeroDavid T. W. JonesElke PfaffOlaf WittStefan M. PfisterRichard VolckmannJan KosterKatharina KieselKarsten RippeSabine Taschner-MandlPeter AmbrosBenedikt BrorsMatthias SelbachLars FeuerbachFrank WestermannNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-18 (2021) |
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DOAJ |
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EN |
| topic |
Science Q |
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Science Q Sabine A. Hartlieb Lina Sieverling Michal Nadler-Holly Matthias Ziehm Umut H. Toprak Carl Herrmann Naveed Ishaque Konstantin Okonechnikov Moritz Gartlgruber Young-Gyu Park Elisa Maria Wecht Larissa Savelyeva Kai-Oliver Henrich Carolina Rosswog Matthias Fischer Barbara Hero David T. W. Jones Elke Pfaff Olaf Witt Stefan M. Pfister Richard Volckmann Jan Koster Katharina Kiesel Karsten Rippe Sabine Taschner-Mandl Peter Ambros Benedikt Brors Matthias Selbach Lars Feuerbach Frank Westermann Alternative lengthening of telomeres in childhood neuroblastoma from genome to proteome |
| description |
Alternative lengthening of telomeres (ALT) is associated with a poor outcome in neuroblastoma. Here, the authors find that ALT is associated with mutated ATRX and/or reduced protein abundance, frequent telomeric repeat loci and heterochromatic telomeric chromatin. |
| format |
article |
| author |
Sabine A. Hartlieb Lina Sieverling Michal Nadler-Holly Matthias Ziehm Umut H. Toprak Carl Herrmann Naveed Ishaque Konstantin Okonechnikov Moritz Gartlgruber Young-Gyu Park Elisa Maria Wecht Larissa Savelyeva Kai-Oliver Henrich Carolina Rosswog Matthias Fischer Barbara Hero David T. W. Jones Elke Pfaff Olaf Witt Stefan M. Pfister Richard Volckmann Jan Koster Katharina Kiesel Karsten Rippe Sabine Taschner-Mandl Peter Ambros Benedikt Brors Matthias Selbach Lars Feuerbach Frank Westermann |
| author_facet |
Sabine A. Hartlieb Lina Sieverling Michal Nadler-Holly Matthias Ziehm Umut H. Toprak Carl Herrmann Naveed Ishaque Konstantin Okonechnikov Moritz Gartlgruber Young-Gyu Park Elisa Maria Wecht Larissa Savelyeva Kai-Oliver Henrich Carolina Rosswog Matthias Fischer Barbara Hero David T. W. Jones Elke Pfaff Olaf Witt Stefan M. Pfister Richard Volckmann Jan Koster Katharina Kiesel Karsten Rippe Sabine Taschner-Mandl Peter Ambros Benedikt Brors Matthias Selbach Lars Feuerbach Frank Westermann |
| author_sort |
Sabine A. Hartlieb |
| title |
Alternative lengthening of telomeres in childhood neuroblastoma from genome to proteome |
| title_short |
Alternative lengthening of telomeres in childhood neuroblastoma from genome to proteome |
| title_full |
Alternative lengthening of telomeres in childhood neuroblastoma from genome to proteome |
| title_fullStr |
Alternative lengthening of telomeres in childhood neuroblastoma from genome to proteome |
| title_full_unstemmed |
Alternative lengthening of telomeres in childhood neuroblastoma from genome to proteome |
| title_sort |
alternative lengthening of telomeres in childhood neuroblastoma from genome to proteome |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/451b2c4a26e94327b98d615c78ab75da |
| work_keys_str_mv |
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