Identification of anticholinergic activity of drugs of the Brazilian National List of Essential Drugs

Objectives: Identify drugs from the National List of Essential Medicines-Rename 2018 that have anticholinergic activity and scales of anticholinergic activity available for use in clinical practice. Methods: Drug utilization study, emphasizing the analysis of supply. The drugs included in Brazilian...

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Autores principales:	Mariana S. LIMA, Adriano M. REIS
Formato:	article
Lenguaje:	EN PT
Publicado:	Sociedade Brasileira de Farmácia Hospitalar e Serviços de Saúde 2020
Materias:	Public aspects of medicine RA1-1270 Pharmacy and materia medica RS1-441 Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/451dd1491bd84754baf9ddae695b715c
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spelling	oai:doaj.org-article:451dd1491bd84754baf9ddae695b715c2021-11-28T02:45:03ZIdentification of anticholinergic activity of drugs of the Brazilian National List of Essential Drugs10.30968/rbfhss.2020.112.03502179-59242316-7750https://doaj.org/article/451dd1491bd84754baf9ddae695b715c2020-07-01T00:00:00Zhttps://www.rbfhss.org.br/sbrafh/article/view/350https://doaj.org/toc/2179-5924https://doaj.org/toc/2316-7750 Objectives: Identify drugs from the National List of Essential Medicines-Rename 2018 that have anticholinergic activity and scales of anticholinergic activity available for use in clinical practice. Methods: Drug utilization study, emphasizing the analysis of supply. The drugs included in Brazilian National List of Essential Drugs (BNLED) 2018 were classified according to level 3 of the chemical therapeutic anatomical classification. A literature review was performed to identify anticholinergic activity measurement scales. Anticholinergic activity of BNLED 2018 drugs was determined using the Composite anticholinergic scale. Results: It was identified two systematic reviews, among the 13 identified scales, Duran's Scale and Composite Anticholinergic Scale. Composite Anticholinergic Scale is the most comprehensive with 197 drugs. It was found that 14.6% of the drugs have anticholinergic activity and 69.1% are included in the basic component of the national list. Drugs with central nervous system activity constitute about 50% of the substances with anticholinergic activity, mainly comprised of antipsychotics, followed by cardiovascular system drugs, mostly represented by betablockers. The cumulative effect of anticholinergic activities, from several drugs prescribed concomitantly, reflects the importance of verifying prescriptions and aware health professionals of strategies to reduce this impact. Conclusions: To measure anticholinergic load in clinical practice, 13 scales are available. The most comprehensive scale is the Composite Anticholinergic Scale. Although medicines with anticholinergic activity are uncommon among medicines included in BNLED 2018, it is needed to provide information to prescribers due to the negative clinical outcomes attributed to cumulative anticholinergic burden. Mariana S. LIMAAdriano M. REISSociedade Brasileira de Farmácia Hospitalar e Serviços de SaúdearticlePublic aspects of medicineRA1-1270Pharmacy and materia medicaRS1-441Therapeutics. PharmacologyRM1-950ENPTRevista Brasileira de Farmácia Hospitalar e Serviços de Saúde, Vol 11, Iss 2 (2020)
institution	DOAJ
collection	DOAJ
language	EN PT
topic	Public aspects of medicine RA1-1270 Pharmacy and materia medica RS1-441 Therapeutics. Pharmacology RM1-950
spellingShingle	Public aspects of medicine RA1-1270 Pharmacy and materia medica RS1-441 Therapeutics. Pharmacology RM1-950 Mariana S. LIMA Adriano M. REIS Identification of anticholinergic activity of drugs of the Brazilian National List of Essential Drugs
description	Objectives: Identify drugs from the National List of Essential Medicines-Rename 2018 that have anticholinergic activity and scales of anticholinergic activity available for use in clinical practice. Methods: Drug utilization study, emphasizing the analysis of supply. The drugs included in Brazilian National List of Essential Drugs (BNLED) 2018 were classified according to level 3 of the chemical therapeutic anatomical classification. A literature review was performed to identify anticholinergic activity measurement scales. Anticholinergic activity of BNLED 2018 drugs was determined using the Composite anticholinergic scale. Results: It was identified two systematic reviews, among the 13 identified scales, Duran's Scale and Composite Anticholinergic Scale. Composite Anticholinergic Scale is the most comprehensive with 197 drugs. It was found that 14.6% of the drugs have anticholinergic activity and 69.1% are included in the basic component of the national list. Drugs with central nervous system activity constitute about 50% of the substances with anticholinergic activity, mainly comprised of antipsychotics, followed by cardiovascular system drugs, mostly represented by betablockers. The cumulative effect of anticholinergic activities, from several drugs prescribed concomitantly, reflects the importance of verifying prescriptions and aware health professionals of strategies to reduce this impact. Conclusions: To measure anticholinergic load in clinical practice, 13 scales are available. The most comprehensive scale is the Composite Anticholinergic Scale. Although medicines with anticholinergic activity are uncommon among medicines included in BNLED 2018, it is needed to provide information to prescribers due to the negative clinical outcomes attributed to cumulative anticholinergic burden.
format	article
author	Mariana S. LIMA Adriano M. REIS
author_facet	Mariana S. LIMA Adriano M. REIS
author_sort	Mariana S. LIMA
title	Identification of anticholinergic activity of drugs of the Brazilian National List of Essential Drugs
title_short	Identification of anticholinergic activity of drugs of the Brazilian National List of Essential Drugs
title_full	Identification of anticholinergic activity of drugs of the Brazilian National List of Essential Drugs
title_fullStr	Identification of anticholinergic activity of drugs of the Brazilian National List of Essential Drugs
title_full_unstemmed	Identification of anticholinergic activity of drugs of the Brazilian National List of Essential Drugs
title_sort	identification of anticholinergic activity of drugs of the brazilian national list of essential drugs
publisher	Sociedade Brasileira de Farmácia Hospitalar e Serviços de Saúde
publishDate	2020
url	https://doaj.org/article/451dd1491bd84754baf9ddae695b715c
work_keys_str_mv	AT marianaslima identificationofanticholinergicactivityofdrugsofthebraziliannationallistofessentialdrugs AT adrianomreis identificationofanticholinergicactivityofdrugsofthebraziliannationallistofessentialdrugs
_version_	1718408436988772352

Identification of anticholinergic activity of drugs of the Brazilian National List of Essential Drugs

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