Application of supercritical antisolvent method in drug encapsulation: a review

Mahshid Kalani, Robiah YunusChemical and Environmental Engineering, Faculty of Engineering, University Putra Malaysia, Selangor Darul Ehsan, MalaysiaAbstract: The review focuses on the application of supercritical fluids as antisolvents in the pharmaceutical field and demonstrates the supercritical...

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Autores principales:	Kalani M, Yunus R
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2011
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/451ec90e9ee04396aba8a68f0faaf852
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spelling	oai:doaj.org-article:451ec90e9ee04396aba8a68f0faaf8522021-12-02T01:13:05ZApplication of supercritical antisolvent method in drug encapsulation: a review1176-91141178-2013https://doaj.org/article/451ec90e9ee04396aba8a68f0faaf8522011-07-01T00:00:00Zhttp://www.dovepress.com/application-of-supercritical-antisolvent-method-in-drug-encapsulation--a7812https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Mahshid Kalani, Robiah YunusChemical and Environmental Engineering, Faculty of Engineering, University Putra Malaysia, Selangor Darul Ehsan, MalaysiaAbstract: The review focuses on the application of supercritical fluids as antisolvents in the pharmaceutical field and demonstrates the supercritical antisolvent method in the use of drug encapsulation. The main factors for choosing the solvent and biodegradable polymer to produce fine particles to ensure effective drug delivery are emphasized and the effect of polymer structure on drug encapsulation is illustrated. The review also demonstrates the drug release mechanism and polymeric controlled release system, and discusses the effects of the various conditions in the process, such as pressure, temperature, concentration, chemical compositions (organic solvents, drug, and biodegradable polymer), nozzle geometry, CO2 flow rate, and the liquid phase flow rate on particle size and its distribution.Keywords: supercritical antisolvent method, drug encapsulation, particle size, drug release mechanisms, drug deliveryKalani MYunus RDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2011, Iss default, Pp 1429-1442 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Kalani M Yunus R Application of supercritical antisolvent method in drug encapsulation: a review
description	Mahshid Kalani, Robiah YunusChemical and Environmental Engineering, Faculty of Engineering, University Putra Malaysia, Selangor Darul Ehsan, MalaysiaAbstract: The review focuses on the application of supercritical fluids as antisolvents in the pharmaceutical field and demonstrates the supercritical antisolvent method in the use of drug encapsulation. The main factors for choosing the solvent and biodegradable polymer to produce fine particles to ensure effective drug delivery are emphasized and the effect of polymer structure on drug encapsulation is illustrated. The review also demonstrates the drug release mechanism and polymeric controlled release system, and discusses the effects of the various conditions in the process, such as pressure, temperature, concentration, chemical compositions (organic solvents, drug, and biodegradable polymer), nozzle geometry, CO2 flow rate, and the liquid phase flow rate on particle size and its distribution.Keywords: supercritical antisolvent method, drug encapsulation, particle size, drug release mechanisms, drug delivery
format	article
author	Kalani M Yunus R
author_facet	Kalani M Yunus R
author_sort	Kalani M
title	Application of supercritical antisolvent method in drug encapsulation: a review
title_short	Application of supercritical antisolvent method in drug encapsulation: a review
title_full	Application of supercritical antisolvent method in drug encapsulation: a review
title_fullStr	Application of supercritical antisolvent method in drug encapsulation: a review
title_full_unstemmed	Application of supercritical antisolvent method in drug encapsulation: a review
title_sort	application of supercritical antisolvent method in drug encapsulation: a review
publisher	Dove Medical Press
publishDate	2011
url	https://doaj.org/article/451ec90e9ee04396aba8a68f0faaf852
work_keys_str_mv	AT kalanim applicationofsupercriticalantisolventmethodindrugencapsulationareview AT yunusr applicationofsupercriticalantisolventmethodindrugencapsulationareview
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Application of supercritical antisolvent method in drug encapsulation: a review

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