Galectin-9 binds IgM-BCR to regulate B cell signaling

The galectin family of secreted lectins are important regulators of immune cell function; however, their role in B cell responses is poorly understood. Here, the authors identify IgM-BCR as a ligand for galectin-9. In resting naive cells, they show that galectin-9 mediates a close association betwee...

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Autores principales:	Anh Cao, Nouf Alluqmani, Fatima Hifza Mohammed Buhari, Laabiah Wasim, Logan K. Smith, Andrew T. Quaile, Michael Shannon, Zaki Hakim, Hossai Furmli, Dylan M. Owen, Alexei Savchenko, Bebhinn Treanor
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4521a98af6a84e3a91478894d92db95c
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spelling	oai:doaj.org-article:4521a98af6a84e3a91478894d92db95c2021-12-02T14:40:08ZGalectin-9 binds IgM-BCR to regulate B cell signaling10.1038/s41467-018-05771-82041-1723https://doaj.org/article/4521a98af6a84e3a91478894d92db95c2018-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05771-8https://doaj.org/toc/2041-1723The galectin family of secreted lectins are important regulators of immune cell function; however, their role in B cell responses is poorly understood. Here, the authors identify IgM-BCR as a ligand for galectin-9. In resting naive cells, they show that galectin-9 mediates a close association between IgM and CD22.Anh CaoNouf AlluqmaniFatima Hifza Mohammed BuhariLaabiah WasimLogan K. SmithAndrew T. QuaileMichael ShannonZaki HakimHossai FurmliDylan M. OwenAlexei SavchenkoBebhinn TreanorNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-18 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Anh Cao Nouf Alluqmani Fatima Hifza Mohammed Buhari Laabiah Wasim Logan K. Smith Andrew T. Quaile Michael Shannon Zaki Hakim Hossai Furmli Dylan M. Owen Alexei Savchenko Bebhinn Treanor Galectin-9 binds IgM-BCR to regulate B cell signaling
description	The galectin family of secreted lectins are important regulators of immune cell function; however, their role in B cell responses is poorly understood. Here, the authors identify IgM-BCR as a ligand for galectin-9. In resting naive cells, they show that galectin-9 mediates a close association between IgM and CD22.
format	article
author	Anh Cao Nouf Alluqmani Fatima Hifza Mohammed Buhari Laabiah Wasim Logan K. Smith Andrew T. Quaile Michael Shannon Zaki Hakim Hossai Furmli Dylan M. Owen Alexei Savchenko Bebhinn Treanor
author_facet	Anh Cao Nouf Alluqmani Fatima Hifza Mohammed Buhari Laabiah Wasim Logan K. Smith Andrew T. Quaile Michael Shannon Zaki Hakim Hossai Furmli Dylan M. Owen Alexei Savchenko Bebhinn Treanor
author_sort	Anh Cao
title	Galectin-9 binds IgM-BCR to regulate B cell signaling
title_short	Galectin-9 binds IgM-BCR to regulate B cell signaling
title_full	Galectin-9 binds IgM-BCR to regulate B cell signaling
title_fullStr	Galectin-9 binds IgM-BCR to regulate B cell signaling
title_full_unstemmed	Galectin-9 binds IgM-BCR to regulate B cell signaling
title_sort	galectin-9 binds igm-bcr to regulate b cell signaling
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/4521a98af6a84e3a91478894d92db95c
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Galectin-9 binds IgM-BCR to regulate B cell signaling

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