Acute kidney injury and acute kidney recovery following Transcatheter Aortic Valve Replacement.
<h4>Background</h4>Acute kidney injury (AKI) is associated with a dismal prognosis in Transcatheter Aortic Valve replacement (TAVR). Acute kidney recovery (AKR), a phenomenon reverse to AKI has recently been associated with better outcomes.<h4>Methods</h4>Between November 201...
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2021
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oai:doaj.org-article:4527b38f66b2484894cf9f4763a5a48f2021-12-02T20:18:28ZAcute kidney injury and acute kidney recovery following Transcatheter Aortic Valve Replacement.1932-620310.1371/journal.pone.0255806https://doaj.org/article/4527b38f66b2484894cf9f4763a5a48f2021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0255806https://doaj.org/toc/1932-6203<h4>Background</h4>Acute kidney injury (AKI) is associated with a dismal prognosis in Transcatheter Aortic Valve replacement (TAVR). Acute kidney recovery (AKR), a phenomenon reverse to AKI has recently been associated with better outcomes.<h4>Methods</h4>Between November 2012 to May 2018, we explored consecutive patients referred to our Heart Valve Center for TAVR. AKI was defined according to the VARC-2 definition. Mirroring the VARC-2 definition of AKI, AKR was defined as a decrease in serum creatinine (≥50%) or ≥25% improvement in GFR up to 72 hours after TAVR.<h4>Results</h4>AKI and AKR were respectively observed in 8.3 and 15.7% of the 574 patients included. AKI and AKR patients were associated to more advanced kidney disease at baseline. At a median follow-up of 608 days (range 355-893), AKI and AKR patients experienced an increased cardiovascular mortality compared to unchanged renal function patients (14.6% and 17.8% respectively, vs. 8.1%, CI 95%, p<0.022). Chronic kidney disease, (HR: 3.9; 95% CI 1.7-9.2; p < 0.001) was the strongest independent factor associated with AKI similarly to baseline creatinine level (HR: 1; 95% CI 1 to 1.1 p < 0.001) for AKR. 72-hours post procedural AKR (HR: 2.26; 95% CI 1.14 to 4.88; p = 0.021) was the strongest independent predictor of CV mortality.<h4>Conclusions</h4>Both AKR and AKI negatively impact long term clinical outcomes of patients undergoing TAVR.Marilou PeillexBenjamin MarchandotKensuke MatsushitaEric PrinzSebastien HessAntje ReydelMarion KiblerAdrien CarmonaAntonin TrimailleJoe HegerHélène Petit-EisenmannAnnie TrinhLaurence JeselPatrick OhlmannOlivier MorelPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 8, p e0255806 (2021) |
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DOAJ |
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DOAJ |
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EN |
| topic |
Medicine R Science Q |
| spellingShingle |
Medicine R Science Q Marilou Peillex Benjamin Marchandot Kensuke Matsushita Eric Prinz Sebastien Hess Antje Reydel Marion Kibler Adrien Carmona Antonin Trimaille Joe Heger Hélène Petit-Eisenmann Annie Trinh Laurence Jesel Patrick Ohlmann Olivier Morel Acute kidney injury and acute kidney recovery following Transcatheter Aortic Valve Replacement. |
| description |
<h4>Background</h4>Acute kidney injury (AKI) is associated with a dismal prognosis in Transcatheter Aortic Valve replacement (TAVR). Acute kidney recovery (AKR), a phenomenon reverse to AKI has recently been associated with better outcomes.<h4>Methods</h4>Between November 2012 to May 2018, we explored consecutive patients referred to our Heart Valve Center for TAVR. AKI was defined according to the VARC-2 definition. Mirroring the VARC-2 definition of AKI, AKR was defined as a decrease in serum creatinine (≥50%) or ≥25% improvement in GFR up to 72 hours after TAVR.<h4>Results</h4>AKI and AKR were respectively observed in 8.3 and 15.7% of the 574 patients included. AKI and AKR patients were associated to more advanced kidney disease at baseline. At a median follow-up of 608 days (range 355-893), AKI and AKR patients experienced an increased cardiovascular mortality compared to unchanged renal function patients (14.6% and 17.8% respectively, vs. 8.1%, CI 95%, p<0.022). Chronic kidney disease, (HR: 3.9; 95% CI 1.7-9.2; p < 0.001) was the strongest independent factor associated with AKI similarly to baseline creatinine level (HR: 1; 95% CI 1 to 1.1 p < 0.001) for AKR. 72-hours post procedural AKR (HR: 2.26; 95% CI 1.14 to 4.88; p = 0.021) was the strongest independent predictor of CV mortality.<h4>Conclusions</h4>Both AKR and AKI negatively impact long term clinical outcomes of patients undergoing TAVR. |
| format |
article |
| author |
Marilou Peillex Benjamin Marchandot Kensuke Matsushita Eric Prinz Sebastien Hess Antje Reydel Marion Kibler Adrien Carmona Antonin Trimaille Joe Heger Hélène Petit-Eisenmann Annie Trinh Laurence Jesel Patrick Ohlmann Olivier Morel |
| author_facet |
Marilou Peillex Benjamin Marchandot Kensuke Matsushita Eric Prinz Sebastien Hess Antje Reydel Marion Kibler Adrien Carmona Antonin Trimaille Joe Heger Hélène Petit-Eisenmann Annie Trinh Laurence Jesel Patrick Ohlmann Olivier Morel |
| author_sort |
Marilou Peillex |
| title |
Acute kidney injury and acute kidney recovery following Transcatheter Aortic Valve Replacement. |
| title_short |
Acute kidney injury and acute kidney recovery following Transcatheter Aortic Valve Replacement. |
| title_full |
Acute kidney injury and acute kidney recovery following Transcatheter Aortic Valve Replacement. |
| title_fullStr |
Acute kidney injury and acute kidney recovery following Transcatheter Aortic Valve Replacement. |
| title_full_unstemmed |
Acute kidney injury and acute kidney recovery following Transcatheter Aortic Valve Replacement. |
| title_sort |
acute kidney injury and acute kidney recovery following transcatheter aortic valve replacement. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2021 |
| url |
https://doaj.org/article/4527b38f66b2484894cf9f4763a5a48f |
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