Spotlight on reticular pseudodrusen

Alessandro Rabiolo,1 Riccardo Sacconi,1,2 Maria Vittoria Cicinelli,1 Lea Querques,1,3 Francesco Bandello,1 Giuseppe Querques1 1Department of Ophthalmology, University Vita-Salute, IRCCS San Raffaele, Milan, 2Eye Clinic, Department of Neurological and Movement Sciences, University of Verona, Verona,...

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Autores principales:	Rabiolo A, Sacconi R, Cicinelli MV, Querques L, Bandello F, Querques G
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	age-related macular degeneration choroidal neovascularization geographic atrophy reticular macular degeneration reticular drusen reticular macular disease reticular pseudodrusen subretinal drusenoid deposit Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/452b3068ae8344c793328201911029ea
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spelling	oai:doaj.org-article:452b3068ae8344c793328201911029ea2021-12-02T01:06:52ZSpotlight on reticular pseudodrusen1177-5483https://doaj.org/article/452b3068ae8344c793328201911029ea2017-09-01T00:00:00Zhttps://www.dovepress.com/spotlight-on-reticular-pseudodrusen-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Alessandro Rabiolo,1 Riccardo Sacconi,1,2 Maria Vittoria Cicinelli,1 Lea Querques,1,3 Francesco Bandello,1 Giuseppe Querques1 1Department of Ophthalmology, University Vita-Salute, IRCCS San Raffaele, Milan, 2Eye Clinic, Department of Neurological and Movement Sciences, University of Verona, Verona, 3G. B. Bietti Foundation-IRCCS, Rome, Italy Abstract: Age-related macular degeneration (AMD) is a leading cause of vision loss in patients >50 years old. The hallmark of the disease is represented by the accumulation of extracellular material between retinal pigment epithelium and the inner collagenous layer of Bruch’s membrane, called drusen. Although identified almost 30 years ago, reticular pseudodrusen (RPD) have been recently recognized as a distinctive phenotype. Unlike drusen, they are located in the subretinal space. RPD are strongly associated with late AMD, especially geographic atrophy, type 2 and 3 choroidal neovascularization, which, in turn, are less common in typical AMD. RPD identification is not straightforward at fundus examination, and their identification should employ at least 2 different imaging modalities. In this narrative review, we embrace all aspects of RPD, including history, epidemiology, histology, imaging, functional test, natural history and therapy. Keywords: age-related macular degeneration, choroidal neovascularization, geographic atrophy, reticular macular degeneration, reticular drusen, reticular macular disease, reticular pseudodrusen, subretinal drusenoid depositRabiolo ASacconi RCicinelli MVQuerques LBandello FQuerques GDove Medical Pressarticleage-related macular degenerationchoroidal neovascularizationgeographic atrophyreticular macular degenerationreticular drusenreticular macular diseasereticular pseudodrusensubretinal drusenoid depositOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 11, Pp 1707-1718 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	age-related macular degeneration choroidal neovascularization geographic atrophy reticular macular degeneration reticular drusen reticular macular disease reticular pseudodrusen subretinal drusenoid deposit Ophthalmology RE1-994
spellingShingle	age-related macular degeneration choroidal neovascularization geographic atrophy reticular macular degeneration reticular drusen reticular macular disease reticular pseudodrusen subretinal drusenoid deposit Ophthalmology RE1-994 Rabiolo A Sacconi R Cicinelli MV Querques L Bandello F Querques G Spotlight on reticular pseudodrusen
description	Alessandro Rabiolo,1 Riccardo Sacconi,1,2 Maria Vittoria Cicinelli,1 Lea Querques,1,3 Francesco Bandello,1 Giuseppe Querques1 1Department of Ophthalmology, University Vita-Salute, IRCCS San Raffaele, Milan, 2Eye Clinic, Department of Neurological and Movement Sciences, University of Verona, Verona, 3G. B. Bietti Foundation-IRCCS, Rome, Italy Abstract: Age-related macular degeneration (AMD) is a leading cause of vision loss in patients >50 years old. The hallmark of the disease is represented by the accumulation of extracellular material between retinal pigment epithelium and the inner collagenous layer of Bruch’s membrane, called drusen. Although identified almost 30 years ago, reticular pseudodrusen (RPD) have been recently recognized as a distinctive phenotype. Unlike drusen, they are located in the subretinal space. RPD are strongly associated with late AMD, especially geographic atrophy, type 2 and 3 choroidal neovascularization, which, in turn, are less common in typical AMD. RPD identification is not straightforward at fundus examination, and their identification should employ at least 2 different imaging modalities. In this narrative review, we embrace all aspects of RPD, including history, epidemiology, histology, imaging, functional test, natural history and therapy. Keywords: age-related macular degeneration, choroidal neovascularization, geographic atrophy, reticular macular degeneration, reticular drusen, reticular macular disease, reticular pseudodrusen, subretinal drusenoid deposit
format	article
author	Rabiolo A Sacconi R Cicinelli MV Querques L Bandello F Querques G
author_facet	Rabiolo A Sacconi R Cicinelli MV Querques L Bandello F Querques G
author_sort	Rabiolo A
title	Spotlight on reticular pseudodrusen
title_short	Spotlight on reticular pseudodrusen
title_full	Spotlight on reticular pseudodrusen
title_fullStr	Spotlight on reticular pseudodrusen
title_full_unstemmed	Spotlight on reticular pseudodrusen
title_sort	spotlight on reticular pseudodrusen
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/452b3068ae8344c793328201911029ea
work_keys_str_mv	AT rabioloa spotlightonreticularpseudodrusen AT sacconir spotlightonreticularpseudodrusen AT cicinellimv spotlightonreticularpseudodrusen AT querquesl spotlightonreticularpseudodrusen AT bandellof spotlightonreticularpseudodrusen AT querquesg spotlightonreticularpseudodrusen
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Spotlight on reticular pseudodrusen

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