Portable eye-tracking as a reliable assessment of oculomotor, cognitive and reaction time function: Normative data for 18-45 year old.

Eye movements measured by high precision eye-tracking technology represent a sensitive, objective, and non-invasive method to probe functional neural pathways. Oculomotor tests (e.g., saccades and smooth pursuit), tests that involve cognitive processing (e.g., antisaccade and predictive saccade), an...

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Autores principales:	Aura Kullmann, Robin C Ashmore, Alexandr Braverman, Christian Mazur, Hillary Snapp, Erin Williams, Mikhaylo Szczupak, Sara Murphy, Kathryn Marshall, James Crawford, Carey D Balaban, Michael Hoffer, Alexander Kiderman
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/452e6fe5ac414ad2998b2f8a815b673c
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spelling	oai:doaj.org-article:452e6fe5ac414ad2998b2f8a815b673c2021-12-02T20:19:08ZPortable eye-tracking as a reliable assessment of oculomotor, cognitive and reaction time function: Normative data for 18-45 year old.1932-620310.1371/journal.pone.0260351https://doaj.org/article/452e6fe5ac414ad2998b2f8a815b673c2021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0260351https://doaj.org/toc/1932-6203Eye movements measured by high precision eye-tracking technology represent a sensitive, objective, and non-invasive method to probe functional neural pathways. Oculomotor tests (e.g., saccades and smooth pursuit), tests that involve cognitive processing (e.g., antisaccade and predictive saccade), and reaction time tests have increasingly been showing utility in the diagnosis and monitoring of mild traumatic brain injury (mTBI) in research settings. Currently, the adoption of these tests into clinical practice is hampered by a lack of a normative data set. The goal of this study was to construct a normative database to be used as a reference for comparing patients' results. Oculomotor, cognitive, and reaction time tests were administered to male and female volunteers, aged 18-45, who were free of any neurological, vestibular disorders, or other head injuries. Tests were delivered using either a rotatory chair equipped with video-oculography goggles (VOG) or a portable virtual reality-like VOG goggle device with incorporated infrared eye-tracking technology. Statistical analysis revealed no effects of age on test metrics when participant data were divided into pediatric (i.e.,18-21 years, following FDA criteria) and adult (i.e., 21-45 years) groups. Gender (self-reported) had an effect on auditory reaction time, with males being faster than females. Pooled data were used to construct a normative database using 95% reference intervals (RI) with 90% confidence intervals on the upper and lower limits of the RI. The availability of these RIs readily allows clinicians to identify specific metrics that are deficient, therefore aiding in rapid triage, informing and monitoring treatment and/or rehabilitation protocols, and aiding in the return to duty/activity decision. This database is FDA cleared for use in clinical practice (K192186).Aura KullmannRobin C AshmoreAlexandr BravermanChristian MazurHillary SnappErin WilliamsMikhaylo SzczupakSara MurphyKathryn MarshallJames CrawfordCarey D BalabanMichael HofferAlexander KidermanPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 11, p e0260351 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Aura Kullmann Robin C Ashmore Alexandr Braverman Christian Mazur Hillary Snapp Erin Williams Mikhaylo Szczupak Sara Murphy Kathryn Marshall James Crawford Carey D Balaban Michael Hoffer Alexander Kiderman Portable eye-tracking as a reliable assessment of oculomotor, cognitive and reaction time function: Normative data for 18-45 year old.
description	Eye movements measured by high precision eye-tracking technology represent a sensitive, objective, and non-invasive method to probe functional neural pathways. Oculomotor tests (e.g., saccades and smooth pursuit), tests that involve cognitive processing (e.g., antisaccade and predictive saccade), and reaction time tests have increasingly been showing utility in the diagnosis and monitoring of mild traumatic brain injury (mTBI) in research settings. Currently, the adoption of these tests into clinical practice is hampered by a lack of a normative data set. The goal of this study was to construct a normative database to be used as a reference for comparing patients' results. Oculomotor, cognitive, and reaction time tests were administered to male and female volunteers, aged 18-45, who were free of any neurological, vestibular disorders, or other head injuries. Tests were delivered using either a rotatory chair equipped with video-oculography goggles (VOG) or a portable virtual reality-like VOG goggle device with incorporated infrared eye-tracking technology. Statistical analysis revealed no effects of age on test metrics when participant data were divided into pediatric (i.e.,18-21 years, following FDA criteria) and adult (i.e., 21-45 years) groups. Gender (self-reported) had an effect on auditory reaction time, with males being faster than females. Pooled data were used to construct a normative database using 95% reference intervals (RI) with 90% confidence intervals on the upper and lower limits of the RI. The availability of these RIs readily allows clinicians to identify specific metrics that are deficient, therefore aiding in rapid triage, informing and monitoring treatment and/or rehabilitation protocols, and aiding in the return to duty/activity decision. This database is FDA cleared for use in clinical practice (K192186).
format	article
author	Aura Kullmann Robin C Ashmore Alexandr Braverman Christian Mazur Hillary Snapp Erin Williams Mikhaylo Szczupak Sara Murphy Kathryn Marshall James Crawford Carey D Balaban Michael Hoffer Alexander Kiderman
author_facet	Aura Kullmann Robin C Ashmore Alexandr Braverman Christian Mazur Hillary Snapp Erin Williams Mikhaylo Szczupak Sara Murphy Kathryn Marshall James Crawford Carey D Balaban Michael Hoffer Alexander Kiderman
author_sort	Aura Kullmann
title	Portable eye-tracking as a reliable assessment of oculomotor, cognitive and reaction time function: Normative data for 18-45 year old.
title_short	Portable eye-tracking as a reliable assessment of oculomotor, cognitive and reaction time function: Normative data for 18-45 year old.
title_full	Portable eye-tracking as a reliable assessment of oculomotor, cognitive and reaction time function: Normative data for 18-45 year old.
title_fullStr	Portable eye-tracking as a reliable assessment of oculomotor, cognitive and reaction time function: Normative data for 18-45 year old.
title_full_unstemmed	Portable eye-tracking as a reliable assessment of oculomotor, cognitive and reaction time function: Normative data for 18-45 year old.
title_sort	portable eye-tracking as a reliable assessment of oculomotor, cognitive and reaction time function: normative data for 18-45 year old.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/452e6fe5ac414ad2998b2f8a815b673c
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Portable eye-tracking as a reliable assessment of oculomotor, cognitive and reaction time function: Normative data for 18-45 year old.

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