Genome-wide meta-analysis implicates mediators of hair follicle development and morphogenesis in risk for severe acne
Acne vulgaris is a chronic inflammation of the skin, the genetic basis of which is incompletely understood. Here, Petridis et al. perform GWAS and meta-analysis for acne in 26,722 individuals and identify 12 novel risk loci that implicate structure and maintenance of the skin in severe acne risk.
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Nature Portfolio
2018
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oai:doaj.org-article:452ea8192e3a4a489db21942afed2d372021-12-02T17:31:28ZGenome-wide meta-analysis implicates mediators of hair follicle development and morphogenesis in risk for severe acne10.1038/s41467-018-07459-52041-1723https://doaj.org/article/452ea8192e3a4a489db21942afed2d372018-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07459-5https://doaj.org/toc/2041-1723Acne vulgaris is a chronic inflammation of the skin, the genetic basis of which is incompletely understood. Here, Petridis et al. perform GWAS and meta-analysis for acne in 26,722 individuals and identify 12 novel risk loci that implicate structure and maintenance of the skin in severe acne risk.Christos PetridisAlexander A. NavariniNick DandJake SaklatvalaDavid BaudryMichael DuckworthMichael H. AllenCharles J. CurtisSang Hyuck LeeA. David BurdenAlison LaytonVeronique BatailleAndrew E. PinkThe Acne Genetic Study GroupIsabelle CarlavanJohannes J. VoegelTimothy D. SpectorRichard C. TrembathJohn A. McGrathCatherine H. SmithJonathan N. BarkerMichael A. SimpsonNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-8 (2018) |
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DOAJ |
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DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Christos Petridis Alexander A. Navarini Nick Dand Jake Saklatvala David Baudry Michael Duckworth Michael H. Allen Charles J. Curtis Sang Hyuck Lee A. David Burden Alison Layton Veronique Bataille Andrew E. Pink The Acne Genetic Study Group Isabelle Carlavan Johannes J. Voegel Timothy D. Spector Richard C. Trembath John A. McGrath Catherine H. Smith Jonathan N. Barker Michael A. Simpson Genome-wide meta-analysis implicates mediators of hair follicle development and morphogenesis in risk for severe acne |
| description |
Acne vulgaris is a chronic inflammation of the skin, the genetic basis of which is incompletely understood. Here, Petridis et al. perform GWAS and meta-analysis for acne in 26,722 individuals and identify 12 novel risk loci that implicate structure and maintenance of the skin in severe acne risk. |
| format |
article |
| author |
Christos Petridis Alexander A. Navarini Nick Dand Jake Saklatvala David Baudry Michael Duckworth Michael H. Allen Charles J. Curtis Sang Hyuck Lee A. David Burden Alison Layton Veronique Bataille Andrew E. Pink The Acne Genetic Study Group Isabelle Carlavan Johannes J. Voegel Timothy D. Spector Richard C. Trembath John A. McGrath Catherine H. Smith Jonathan N. Barker Michael A. Simpson |
| author_facet |
Christos Petridis Alexander A. Navarini Nick Dand Jake Saklatvala David Baudry Michael Duckworth Michael H. Allen Charles J. Curtis Sang Hyuck Lee A. David Burden Alison Layton Veronique Bataille Andrew E. Pink The Acne Genetic Study Group Isabelle Carlavan Johannes J. Voegel Timothy D. Spector Richard C. Trembath John A. McGrath Catherine H. Smith Jonathan N. Barker Michael A. Simpson |
| author_sort |
Christos Petridis |
| title |
Genome-wide meta-analysis implicates mediators of hair follicle development and morphogenesis in risk for severe acne |
| title_short |
Genome-wide meta-analysis implicates mediators of hair follicle development and morphogenesis in risk for severe acne |
| title_full |
Genome-wide meta-analysis implicates mediators of hair follicle development and morphogenesis in risk for severe acne |
| title_fullStr |
Genome-wide meta-analysis implicates mediators of hair follicle development and morphogenesis in risk for severe acne |
| title_full_unstemmed |
Genome-wide meta-analysis implicates mediators of hair follicle development and morphogenesis in risk for severe acne |
| title_sort |
genome-wide meta-analysis implicates mediators of hair follicle development and morphogenesis in risk for severe acne |
| publisher |
Nature Portfolio |
| publishDate |
2018 |
| url |
https://doaj.org/article/452ea8192e3a4a489db21942afed2d37 |
| work_keys_str_mv |
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| _version_ |
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