The mitotic kinesin-14 KlpA contains a context-dependent directionality switch

The mitotic kinesin-14 KlpA contains a context-dependent directionality switch

Kinesin-14s are commonly considered to be minus end-directed microtubule motor proteins. Here the authors show that KlpA, a fungal kinesin-14 orthologue, relies on its N-terminal nonmotor microtubule-binding tail to achieve context-dependent bidirectional motility.

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Detalles Bibliográficos
Autores principales: Andrew R. Popchock, Kuo-Fu Tseng, Pan Wang, P. Andrew Karplus, Xin Xiang, Weihong Qiu
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
Materias:
Science
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Acceso en línea:https://doaj.org/article/452fe2c9c270404e86830743dc6002c8
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