Modeling the Effects of Morphine-Altered Virus Specific Antibody Responses on HIV/SIV Dynamics

Abstract Drugs of abuse, such as opiates, have been widely associated with enhancing HIV replication, accelerating disease progression and diminishing host-immune responses, thereby making it harder to effectively manage HIV infection. It is thus important to study the effects of drugs of abuse on H...

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Autores principales:	Jones M. Mutua, Alan S. Perelson, Anil Kumar, Naveen K. Vaidya
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/45318cbade9d48418f2aa8417c9f944d
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spelling	oai:doaj.org-article:45318cbade9d48418f2aa8417c9f944d2021-12-02T15:09:20ZModeling the Effects of Morphine-Altered Virus Specific Antibody Responses on HIV/SIV Dynamics10.1038/s41598-019-41751-82045-2322https://doaj.org/article/45318cbade9d48418f2aa8417c9f944d2019-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-019-41751-8https://doaj.org/toc/2045-2322Abstract Drugs of abuse, such as opiates, have been widely associated with enhancing HIV replication, accelerating disease progression and diminishing host-immune responses, thereby making it harder to effectively manage HIV infection. It is thus important to study the effects of drugs of abuse on HIV-infection and immune responses. Here, we develop mathematical models that incorporate the effects of morphine-altered antibody responses on HIV/SIV dynamics. Based on fitting the model to experimental data from simian immunodeficiency virus (SIV) infections in control and morphine-addicted macaques, we found that two of the most significant effects of virus specific antibodies are neutralizing viral particles and enhancing viral clearance. Using our model, we quantified how morphine alters virus-specific antibody responses, and how this alteration affects the key components of virus dynamics such as infection rate, virus clearance, viral load, CD4+ T cell count, and CD4+ T cell loss in SIV-infected macaques under conditioning with morphine. We found that in a subpopulation of SIV-infected morphine addicted macaques, the presence of drugs of abuse may cause significantly diminished antibody responses, resulting in more severe infection with increased SIV infectivity, a decreased viral clearance rate, increased viral load, and higher CD4+ T cell loss.Jones M. MutuaAlan S. PerelsonAnil KumarNaveen K. VaidyaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 9, Iss 1, Pp 1-11 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jones M. Mutua Alan S. Perelson Anil Kumar Naveen K. Vaidya Modeling the Effects of Morphine-Altered Virus Specific Antibody Responses on HIV/SIV Dynamics
description	Abstract Drugs of abuse, such as opiates, have been widely associated with enhancing HIV replication, accelerating disease progression and diminishing host-immune responses, thereby making it harder to effectively manage HIV infection. It is thus important to study the effects of drugs of abuse on HIV-infection and immune responses. Here, we develop mathematical models that incorporate the effects of morphine-altered antibody responses on HIV/SIV dynamics. Based on fitting the model to experimental data from simian immunodeficiency virus (SIV) infections in control and morphine-addicted macaques, we found that two of the most significant effects of virus specific antibodies are neutralizing viral particles and enhancing viral clearance. Using our model, we quantified how morphine alters virus-specific antibody responses, and how this alteration affects the key components of virus dynamics such as infection rate, virus clearance, viral load, CD4+ T cell count, and CD4+ T cell loss in SIV-infected macaques under conditioning with morphine. We found that in a subpopulation of SIV-infected morphine addicted macaques, the presence of drugs of abuse may cause significantly diminished antibody responses, resulting in more severe infection with increased SIV infectivity, a decreased viral clearance rate, increased viral load, and higher CD4+ T cell loss.
format	article
author	Jones M. Mutua Alan S. Perelson Anil Kumar Naveen K. Vaidya
author_facet	Jones M. Mutua Alan S. Perelson Anil Kumar Naveen K. Vaidya
author_sort	Jones M. Mutua
title	Modeling the Effects of Morphine-Altered Virus Specific Antibody Responses on HIV/SIV Dynamics
title_short	Modeling the Effects of Morphine-Altered Virus Specific Antibody Responses on HIV/SIV Dynamics
title_full	Modeling the Effects of Morphine-Altered Virus Specific Antibody Responses on HIV/SIV Dynamics
title_fullStr	Modeling the Effects of Morphine-Altered Virus Specific Antibody Responses on HIV/SIV Dynamics
title_full_unstemmed	Modeling the Effects of Morphine-Altered Virus Specific Antibody Responses on HIV/SIV Dynamics
title_sort	modeling the effects of morphine-altered virus specific antibody responses on hiv/siv dynamics
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/45318cbade9d48418f2aa8417c9f944d
work_keys_str_mv	AT jonesmmutua modelingtheeffectsofmorphinealteredvirusspecificantibodyresponsesonhivsivdynamics AT alansperelson modelingtheeffectsofmorphinealteredvirusspecificantibodyresponsesonhivsivdynamics AT anilkumar modelingtheeffectsofmorphinealteredvirusspecificantibodyresponsesonhivsivdynamics AT naveenkvaidya modelingtheeffectsofmorphinealteredvirusspecificantibodyresponsesonhivsivdynamics
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Modeling the Effects of Morphine-Altered Virus Specific Antibody Responses on HIV/SIV Dynamics

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