Epidermal Hyaluronan in Barrier Alteration-Related Disease

In skin, although the extracellular matrix (ECM) is highly developed in dermis and hypodermis, discrete intercellular spaces between cells of the living epidermal layers are also filled with ECM components. Herein, we review knowledge about structure, localization and role of epidermal hyaluronan (H...

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Autores principales:	Céline Evrard, Catherine Lambert de Rouvroit, Yves Poumay
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	hyaluronan epidermal extracellular matrix atopic dermatitis Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/4533df450a2d48a1866f9177d0c9f06c
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spelling	oai:doaj.org-article:4533df450a2d48a1866f9177d0c9f06c2021-11-25T17:11:27ZEpidermal Hyaluronan in Barrier Alteration-Related Disease10.3390/cells101130962073-4409https://doaj.org/article/4533df450a2d48a1866f9177d0c9f06c2021-11-01T00:00:00Zhttps://www.mdpi.com/2073-4409/10/11/3096https://doaj.org/toc/2073-4409In skin, although the extracellular matrix (ECM) is highly developed in dermis and hypodermis, discrete intercellular spaces between cells of the living epidermal layers are also filled with ECM components. Herein, we review knowledge about structure, localization and role of epidermal hyaluronan (HA), a key ECM molecule. HA is a non-sulfated glycosaminoglycan non-covalently bound to proteins or lipids. Components of the basal lamina maintain some segregation between the epidermis and the underlying dermis, and all epidermal HA is locally synthesized and degraded. Functions of HA in keratinocyte proliferation and differentiation are still controversial. However, through interactions with partners, such as the TSG-6 protein, HA is involved in the formation, organization and stabilization of the epidermal ECM. In addition, epidermal HA is involved in the formation of an efficient epidermal barrier made of cornified keratinocytes. In atopic dermatitis (AD) with profuse alterations of the epidermal barrier, HA is produced in larger amounts by keratinocytes than in normal skin. Epidermal HA inside AD lesional skin is located in enlarged intercellular spaces, likely as the result of disease-related modifications of HA metabolism.Céline EvrardCatherine Lambert de RouvroitYves PoumayMDPI AGarticlehyaluronanepidermal extracellular matrixatopic dermatitisBiology (General)QH301-705.5ENCells, Vol 10, Iss 3096, p 3096 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	hyaluronan epidermal extracellular matrix atopic dermatitis Biology (General) QH301-705.5
spellingShingle	hyaluronan epidermal extracellular matrix atopic dermatitis Biology (General) QH301-705.5 Céline Evrard Catherine Lambert de Rouvroit Yves Poumay Epidermal Hyaluronan in Barrier Alteration-Related Disease
description	In skin, although the extracellular matrix (ECM) is highly developed in dermis and hypodermis, discrete intercellular spaces between cells of the living epidermal layers are also filled with ECM components. Herein, we review knowledge about structure, localization and role of epidermal hyaluronan (HA), a key ECM molecule. HA is a non-sulfated glycosaminoglycan non-covalently bound to proteins or lipids. Components of the basal lamina maintain some segregation between the epidermis and the underlying dermis, and all epidermal HA is locally synthesized and degraded. Functions of HA in keratinocyte proliferation and differentiation are still controversial. However, through interactions with partners, such as the TSG-6 protein, HA is involved in the formation, organization and stabilization of the epidermal ECM. In addition, epidermal HA is involved in the formation of an efficient epidermal barrier made of cornified keratinocytes. In atopic dermatitis (AD) with profuse alterations of the epidermal barrier, HA is produced in larger amounts by keratinocytes than in normal skin. Epidermal HA inside AD lesional skin is located in enlarged intercellular spaces, likely as the result of disease-related modifications of HA metabolism.
format	article
author	Céline Evrard Catherine Lambert de Rouvroit Yves Poumay
author_facet	Céline Evrard Catherine Lambert de Rouvroit Yves Poumay
author_sort	Céline Evrard
title	Epidermal Hyaluronan in Barrier Alteration-Related Disease
title_short	Epidermal Hyaluronan in Barrier Alteration-Related Disease
title_full	Epidermal Hyaluronan in Barrier Alteration-Related Disease
title_fullStr	Epidermal Hyaluronan in Barrier Alteration-Related Disease
title_full_unstemmed	Epidermal Hyaluronan in Barrier Alteration-Related Disease
title_sort	epidermal hyaluronan in barrier alteration-related disease
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/4533df450a2d48a1866f9177d0c9f06c
work_keys_str_mv	AT celineevrard epidermalhyaluronaninbarrieralterationrelateddisease AT catherinelambertderouvroit epidermalhyaluronaninbarrieralterationrelateddisease AT yvespoumay epidermalhyaluronaninbarrieralterationrelateddisease
_version_	1718412645141315584

Epidermal Hyaluronan in Barrier Alteration-Related Disease

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