FUNDAMENTAL IMMUNOBIOLOGY OF PRO-INFLAMMATORY CYTOKINES AND MIF

Fundamental immunobiology of proinflammatory cytokines and MIFThere are a lot of similarity as well as differences when we compare cytokines with MIF according their biological properties. MIF characteristics are unique structure, organs and tissues ubiquity, extremely wide variety of functions (pro...

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Autores principales:	A. P. Suslov, M. V. Konopleva, O. Yu. Tretiakov
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/45380a9a1f974696a147d9bc8c21cd9f
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spelling	oai:doaj.org-article:45380a9a1f974696a147d9bc8c21cd9f2021-11-18T08:03:40ZFUNDAMENTAL IMMUNOBIOLOGY OF PRO-INFLAMMATORY CYTOKINES AND MIF1563-06252313-741X10.15789/1563-0625-2006-1-5-22https://doaj.org/article/45380a9a1f974696a147d9bc8c21cd9f2014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/409https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XFundamental immunobiology of proinflammatory cytokines and MIFThere are a lot of similarity as well as differences when we compare cytokines with MIF according their biological properties. MIF characteristics are unique structure, organs and tissues ubiquity, extremely wide variety of functions (proinflammatory cytokine, enzyme, hormone), ability to be induced by glucocorticoid hormones and affects as their immunosuppressive effects antagonist. MIF exists in preformed condition in lymphocytes, macrophages and endothelium cells. It secrets by these cells and operates as a mobilizing defense system factor in the first minutes of foreign invasion. MIF exhibits the properties of super-ligand binding with many biologically important molecules. This factor carries out the functions that are important for cell activation, proliferation and death, using a variety of intracellular signaling pathways. Some of MIF homologues exists in plants and bacteria earlier than innate and adaptive immune systems appears in evolution. In ontogenesis MIF appears at the stage of firsts cell divisions. MIF has a lot of functions, variety of ligand bindings, many effector pathways, it appears early in ontogeny and phylogeny. MIF takes part into protective reactions at any levels – from cell up to whole organism. All these MIF features taking together into account make it possible to possess it as a particular type of cytokine – eocytokine (from Greek word “eo” – early). It is assumed that MIF may function as some kind of cells and organisms "natural stability" key factor.A. P. SuslovM. V. KonoplevaO. Yu. TretiakovSPb RAACIarticleImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 8, Iss 1, Pp 5-22 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	Immunologic diseases. Allergy RC581-607
spellingShingle	Immunologic diseases. Allergy RC581-607 A. P. Suslov M. V. Konopleva O. Yu. Tretiakov FUNDAMENTAL IMMUNOBIOLOGY OF PRO-INFLAMMATORY CYTOKINES AND MIF
description	Fundamental immunobiology of proinflammatory cytokines and MIFThere are a lot of similarity as well as differences when we compare cytokines with MIF according their biological properties. MIF characteristics are unique structure, organs and tissues ubiquity, extremely wide variety of functions (proinflammatory cytokine, enzyme, hormone), ability to be induced by glucocorticoid hormones and affects as their immunosuppressive effects antagonist. MIF exists in preformed condition in lymphocytes, macrophages and endothelium cells. It secrets by these cells and operates as a mobilizing defense system factor in the first minutes of foreign invasion. MIF exhibits the properties of super-ligand binding with many biologically important molecules. This factor carries out the functions that are important for cell activation, proliferation and death, using a variety of intracellular signaling pathways. Some of MIF homologues exists in plants and bacteria earlier than innate and adaptive immune systems appears in evolution. In ontogenesis MIF appears at the stage of firsts cell divisions. MIF has a lot of functions, variety of ligand bindings, many effector pathways, it appears early in ontogeny and phylogeny. MIF takes part into protective reactions at any levels – from cell up to whole organism. All these MIF features taking together into account make it possible to possess it as a particular type of cytokine – eocytokine (from Greek word “eo” – early). It is assumed that MIF may function as some kind of cells and organisms "natural stability" key factor.
format	article
author	A. P. Suslov M. V. Konopleva O. Yu. Tretiakov
author_facet	A. P. Suslov M. V. Konopleva O. Yu. Tretiakov
author_sort	A. P. Suslov
title	FUNDAMENTAL IMMUNOBIOLOGY OF PRO-INFLAMMATORY CYTOKINES AND MIF
title_short	FUNDAMENTAL IMMUNOBIOLOGY OF PRO-INFLAMMATORY CYTOKINES AND MIF
title_full	FUNDAMENTAL IMMUNOBIOLOGY OF PRO-INFLAMMATORY CYTOKINES AND MIF
title_fullStr	FUNDAMENTAL IMMUNOBIOLOGY OF PRO-INFLAMMATORY CYTOKINES AND MIF
title_full_unstemmed	FUNDAMENTAL IMMUNOBIOLOGY OF PRO-INFLAMMATORY CYTOKINES AND MIF
title_sort	fundamental immunobiology of pro-inflammatory cytokines and mif
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/45380a9a1f974696a147d9bc8c21cd9f
work_keys_str_mv	AT apsuslov fundamentalimmunobiologyofproinflammatorycytokinesandmif AT mvkonopleva fundamentalimmunobiologyofproinflammatorycytokinesandmif AT oyutretiakov fundamentalimmunobiologyofproinflammatorycytokinesandmif
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FUNDAMENTAL IMMUNOBIOLOGY OF PRO-INFLAMMATORY CYTOKINES AND MIF

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